Factors Related to Quality of Life in Older People with Hepatocellular Carcinoma Undergoing Transarterial Chemoembolization Therapy

Main Article Content

Nattakarn Hongmalai
Tassana Choowattanapakorn

Abstract

Purpose: To study the quality of life in older people with hepatocellular carcinoma undergoing
transarterial chemoembolization therapy and to study the relationships between factors; fatigue,
pain, insomnia, stress and quality of life in older people with hepatocellular carcinoma undergoing
transarterial chemoembolization therapy.
Design: Correlation research
Methods: One hundred and twenty inpatient aged over 60 years old of King Chulalongkorn
Memorial Hospital and Ramathibodi Hospital who had been diagnosis of hepatocellular carcinoma.
The instruments were composed of Demographic information, Piper fatigue scale-12, Numerical
rating scales, Insomnia severity index, Percieved stress scale, functional assessment of cancer
therapy–hepatobiliary (FACT-Hep). The reliabilities of these questionnaires were .96, .78, .95 and
.87 respectively. Data were analyzed by using percentage, mean, standard deviation, Pearson’s
production-moment correlation.
Findings: The mean score of quality of life among older people with hepatocellular carcinoma
undergoing transarterial chemoembolization therapy was shown at the high level. (Mean = 122.47,
S.D. = 18.76). Fatigue, pain, insomnia and stress were negatively related to quality of life in older
people with hepatocellular carcinoma undergoing transarterial chemoembolization therapy at
the medium level of .05 (r =–0.444,–0.540,–0.579,–0.466, respectively)
Conclusion: Health care providers should pay special attention to the assessment and
management of adverse events of older people with hepatocellular carcinoma undergoing
transarterial chemoembolization therapy to reduce the suffering from diseases and adverse
reactions and maintain good quality of life.

Downloads

Download data is not yet available.

Article Details

Section
Research articles

References

The Bureau of Policy and Strategy, Ministry of Public Health. Statistical Thailand 2016. Nonthaburi: Ministry of Public Health; 2016.

Kew MC. Hepatitis B virus x protein in the pathogenesisofhepatitisBvirusinduced hepatocellular carcinoma. Journal of gastroenterology and hepatology 2011;26 suppl 1:144-52. doi:10.1111/ j.1440-1746.2010.06546.x

Cabrera R, Nelson DR. The management of hepatocellular carcinoma. Alimentary pharmacology & therapeutics 2010; 31(4):461-76.

Cao W, Li J, Hu C, Shen J, Liu X, Xu Y, Ye Z. Symptom clusters and symptom interferenceof HCC patientsundergoing TACE: a cross-sectional study in China. Supportive Care in Cancer 2013;21(2):

-83.

Shun SC, Chen CH, Sheu JC, Liang JD, Yang JC, Lai YH. Quality of life and its associated factors in patients with hepatocellular carcinoma receiving one course o f transarterial chemoembolization treatment: a longitudinalstudy.Theoncologist2012; 17(5):732-9.

Hinrichs JB, Hasdemir DB, Nordlohne M, Schweitzer N, Wacker F, Vogel A, et al. Health-Related Quality of Life in Patients with Hepatocellular Carcinoma Treated with Initial Transarterial Chemoembolization. Cardiovascular and Interventional Radiology 2017;40(10):1559-66.

Xie ZR, Luo YL, Xiao FM, Liu Q, Ma Y. Health-related qualityof lifeof patients with intermediate hepatocellular

carcinoma after liver resection or transcatheter arterial chemoembolization. AsianPacific Journalof Cancer

Prevention 2015;16(10):4451-6.

Somjaivong B, Thanasilp S, Preechawong S, Sloan R. The influence of symptoms, social support,uncertainty, and coping onhealth-related qualityof lifeamong cholangiocarcinoma patients in northeast Thailand. Cancer nursing 2011;34(6):434-42. (In thai)

Maninet S. Relationships among Symptoms, Symptom Management, Sense of Coherence, and Quality of Life in Patients with Hepatobiliary Carcinoma. Kuakarun Journal of Nursing 2015; 21(1):161-77. (In thai)

Ryu E, Kim K, Cho MS, Kwon IG, Kim HS, Fu MR. Symptom clusters and quality of lifeinKoreanpatientswithhepatocellular carcinoma. Cancer Nursing 2010;33(1):3-10.

LenzER,PughLC.TheTheoryof Unpleasant Symptoms. In Smith MJ, Liehr PR.(editors.), Middle range theory for nursing.3th ed. New York:Springer;2003. p. 69-90.

Heffernan N, Cella D, Webster K, Odom L, Martone M, Passik S, et al. Measuring health-related qualityof lifein patients with hepatobiliary cancers: the functional assessment of cancer therapy–hepatobiliary questionnaire. Journal of Clinical Oncology 2002; 20(9):2229-39.

ReeveBB,Stover AM, Alfano CM,Smith AW, Ballard-Barbash R, Berstein L, et al. The Piper Fatigue Scale-12 (PFS-12): Psychometricfindingsand itemreduction in a cohort of breast cancer survivors. Breast cancer research and treatment2012;136(1):9-20.

Wongpakaran N, Wongpakaran T. The Thai version of the PSS-10: An Investigation of its psychometric properties. BioPsychoSocialmedicine2010;4(1):1-6.(In thai)

Hinrichs JB, Hasdemir DB, Nordlohne M, Schweitzer N, Wacker F, Vogel A, Rodt T. Health-Related Quality of Life in Patients with Hepatocellular Carcinoma Treated with Initial Transarterial Chemoembolization. Cardiovascular and interventional radiology 2017; 40(10):1559-66.

Fan SY, Eiser C, Ho MC. Health-related quality of life in patients with hepatocellularcarcinoma:asystematic

review. Clinical Gastroenterology and Hepatology 2010;8(7): 559-64.

Palmieri VO, Santovito D, Margari F, Lozupone M, Minerva F, Di Gennaro C, et al. Psychopathological profile and health-related quality of life (HRQOL) in patients with hepatocellular carcinoma (HCC) and cirrhosis. Clinical

and experimental medicine 2015; 15(1):65-72.

Fox SW, Lyon DE. Symptom clusters and qualityof lifeinsurvivorsof lungcancer. In Oncology nursing forum 2006;33(5):931-6.