Risk factors associated with mortality in patients with Streptococcus suis infections: A retrospective cohort study conducted at the Somdejphrajaotaksinmaharaj Hospital in Tak Province, Thailand
Keywords:
Streptococcus suis, Factor, MortalityAbstract
Context: Streptococcus suis is a bacterium that lives in the upper respiratory tracts and digestive tracts of pigs. It is a disease that can be transmitted from animals to humans through direct contact, but also through wounds and other factors, including patient medical history, and can lead to mortality.
Objective: To study the risk factors resulting in death, as well as the general characteristics of the disease, from the medical data of patients diagnosed with a Streptococcus suis infection. The patient group was selected from the Somdejphrajaotaksinmaharaj Hospital in the Tak province in North-West Thailand.
Material and methods: This study was a retrospective cohort study. Data were collected between January 1, 2013 - June 30, 2024 from the medical records at the Somdejprachaotaksinmaharaj Hospital. The medical records included a full investigation report as stored in the hospital’s
HOSxP program. A total of 51 cases were analyzed using descriptive statistics and inferential statistics (Mann-Whitney U test, with significance at 0.05).
Result: The 51 patients, most of whom were male (80.39%), and were living in the Tak province (68.62%), had an average age of 33.30±57.12 years. Many of the patients worked as general laborers (52.94%). The patients had a history of smoking and drinking (78.43% and 41.18%), and had consumed raw pork or pork products, but had no other contact with pork or raw pork (45.10% and 86.27%). The laboratory test results of many of the patients showed a high white blood cell count and a low platelet count (81.60% and 18.40%). The patients were hospitalized for less than or up 15 days, most with symptoms improving (92.16%). However there was a 7.84% mortality rate. Most of the deceased patients were monks (50.00%). Factors to consider were the patient’s occupation and medical history, of either alcoholic liver disease or endocarditis, These three factors were statistically significant regarding patient mortality rates
from Streptococcus suis infections (p = 0.014, 0.010 and 0.025, respectively).
Conclusion: Statistically significant risk factors for mortality in patients with a Streptococcus suis infection were occupation, alcoholic liver disease and endocarditis.
References
Sitthi W, Bongjaporn N, Chalom V. Factors Associated with Streptococcus suis meningitis among patients in Northern Thailand. Lanna Public Health Journal. 2020; 16: 1–12. (in Thai)
Kerdsin A. Human Streptococcus suis Infections in Thailand: epidemiology, clinical features, genotypes, and susceptibility. Trop Med Infect Dis. 2022; 7: 359.
Sampao R, Chaknam T, Rattanathamsakun T. Epidemiological characteristics of the deaths related to Streptococcus suis infection in Thailand between 2016 and 2020. WESR. 2022; 53: 141–50. (in Thai)
Buahong S. Factors affecting the behavior of people in Thung Saliam district, Sukhothai province to prevent swine flu. Science and Technology Northern Journal. 2021; 2: 1–17.
Tak provincial public health office [Internet]. 2015 [accessed Jun 10, 2024]. Available from: http://www.tako.moph. go.th/takmoph2021/.
Kalyanamitra group . Section 4 : bhochanavagga: regarding food [Internet]. 2023 [accessed Jun 20, 2024]. Available from: https://kalyanamitra.org/th/article_ detail.php?i=22128.
Tonesanoi P. Study of Streptococcus suis infection in patients admitted to hospital in Sa Kaeo Province. Chula Med J. 2018; 31: 50–65.(in Thai)
Suankratay C, Intalapaporn P, Nunthapisud P, Arunyingmongkol K, Wilde H. Streptococcus suis meningitis in Thailand. Southeast Asian J Trop Med Public Health. 2004; 35: 868-76.
Samkar A, Brouwer MC, Schultsz C, Ende A, Beek D. Streptococcus suis meningitis: a systematic review and meta-analysis. PLoS Negl Trop Dis. 2015; 9: e0004191.
Praphasiri P, Owusu JT, Thammathitiwat S. Streptococcus suis infection in hospitalized patients, Nakhon Phanom province, Thailand. Emerg Infect Dis, 2015; 21: 345–8. (in Thai)
Fongcom A, Pruksakorn S, Netsirisawan P, Pongprasert R, Onsibud P. Streptococcus suis infection: a prospective study in Northern Thailand. Southeast Asian J Trop Med Public Health. 2009; 40: 511–7.
Singpoltan N. Prevalence and Susceptibility pattern of Streptococcus suis at Maharat Nakhon Ratchasima hospital. J Med Tech Assoc Thailand. 2019; 47: 6896–904. (in Thai)
Nakaranurack C, Puttilerpong C, Suwanpimolkul G. A decennium of etiology and antimicrobial susceptibility patterns in patients with infective endocarditis at a University Hospital, Thailand. Jpn J Infect Dis. 2017; 70: 295-300.
Bamphensin N, Chopjitt P, Hatrongjit R, Boueroy P, Fittipaldi N, Gottschalk M. et al. Non- penicillin-susceptible Streptococcus suis isolated from humans. Pathogens. 2021; 10: 1178. (in Thai)
Rayanakorn A, Katip W, Goh BH, Oberdorfer P, Lee LH. Clinical manifestations and risk factors of Streptococcus suis mortality among Northern Thai population: retrospective 13-year cohort study. Infect Drug Resist. 2019; 12: 3955-65.
Hlebowicz M, Jakubowski P, Smiatacz T. Streptococcus suis meningitis: epidemiology, clinical presentation and treatment. Vector Borne Zoonotic Dis. 2019; 19: 557-62.
Takeuchi D, Kerdsin A, Pienpringam A, Loetthong P, Samerchea S, Luangsuk P, et al. Population-based study of Streptococcus suis infection in humans in Phayao province in northern Thailand. PLoS One. 2012; 7: e31265.
Kalyanamitra. Section 4: Bhochanavagga, regarding food. [Internet]. 2023 [accessed Jun 20, 2024]. Available from: https:// kalyanamitra.org/th/article_detail. php?i=22128.
Kay R, Cheng AF, Tse TY. Streptococcus suis infection in Hong Kong. QJM. 1995; 88: 39–47.
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