ปัจจัยทำนายการเกิดอาการผิดปกติของระบบประสาทส่วนปลายจากเคมีบำบัดในผู้ป่วยมะเร็งลำไส้ใหญ่และไส้ตรงที่ได้รับการรักษาด้วยยาเคมีบำบัด

Sujintorn  Sabamnet; Chongjit  Saneha; Autchariya  Poungkaew; Nopadol  Soparattanapaisan

Authors

Sujintorn Sabamnet Faculty of Nursing, Mahidol University
Chongjit Saneha Faculty of Nursing, Mahidol University
Autchariya Poungkaew Faculty of Nursing, Mahidol University
Nopadol Soparattanapaisan Faculty of Medicine Siriraj Hospital, Mahidol University

Keywords:

physical activity, stress, health literacy, colorectal cancer, chemotherapy-induced peripheral neuropathy

Abstract

This correlational predictive study aimed to determine the predictive factors of chemotherapy-induced peripheral neuropathy (CIPN) in patients with colorectal cancer (CRC) undergoing chemotherapy. One hundred and two samples who met the inclusion criteria were recruited from two tertiary hospitals in Bangkok. Data collection tools included demographic questionnaires, namely EORTC QLQ-CIPN20, Stress test 5, and IPAQ and Health literacy. The reliability of EORTC QLQ-CIPN20, Stress test 5, and Health Literacy using Cronbach’s alpha coefficients were .86, .83, and .93, respectively. Only IPAQ was verified by Test-retest Reliability two weeks apart and its intra-class correlation coefficient (ICC) was equal to .85. The data were analyzed using descriptive statistics and logistic regression analysis by enter method.

The results revealed that the samples were males (51.96%) with a mean age of 60.88 years (SD=10.47), and 90.20% of them had CIPN at a mild level (Mdn=7.40, IQR=9.72). The majority of the samples had mild stress (81.37%), moderate physical activity (55.88%), and high health literacy (81.37%). Age, stress, physical activity, and health literacy can jointly explain the variances of CIPN in patients with CRC undergoing chemotherapy at 41% (Negelkerke R² =.41, p < .05). Only stress variables (OR=2.33, 95%CI=1.08 - 5.02, p= .031) and health literacy variables (OR=.95, 95%CI=.90 - 1.00, p=.041) were statistical predictors of CIPN.

The findings of this study suggest that nurses and the health care team should assess stress, health literacy, and CIPN in order to decrease the risk of CIPN by reducing stress and promoting health literacy in patients with CRC undergoing chemotherapy.

Downloads

Download data is not yet available.

References

Alejandro, L., Behrendt, C. E., Chen, K., Openshaw, H., & Shibata, S. (2013). Predicting acute and persistent neuropathy associated with oxaliplatin. American journal of clinical oncology, 36(4), 331-337.

Altaf, R., Brixen, A. L., Kristensen, B., & Nielsen, S. E. (2014). Incidence of cold-induced peripheral neuropathy and dose modification of adjuvant oxaliplatin-based chemotherapy for patients with colorectal cancer. Oncology, 87(3), 167-172.

Dekker, E., Tanis, J. P., Vleugels, A. J., Kasi, M. P., & Wallace, B. M. (2019). Colorectal cancer. Lancet, 394(1), 1467-1480.

Fernandez, S., Franklin, J., Amlani, N., DeMilleVille, C., Lawson, D., & Smith, J. (2015). Physical activity and cancer: A cross-sectional study on the barriers and facilitators to exercise during cancer treatment. Canadian Oncology Nursing Journal /Revue canadienne de soins infirmiers en oncologie, 25(1), 37-42.

Han, J. W., & Sangsook, H. A. N. (2015). Type of chemotherapy-induced peripheral neuropathy, influencing factors, and functional status. Iranian Journal of Public Health, 44(12), 1701.

Hsu, S. Y., Huang, W. S., Lee, S. H., Chu, T. P., Lin, Y. C., Lu, C.H., . . . Jane, S. W. (2019). Incidence, severity, longitudinal trends and predictors of acute and chronic. Oxaliplatin-Induced peripheral neuropathy in Taiwanese patients with colorectal cancer. European Journal of Cancer Care, 28(2), 12976-12987.

International Physical Activity Questionnaire (IPAQ). (2005). IPAQ scoring protocol. Retrieved from https://sites.google.com/site/theipaq/scoring-protocol

Jiwpanya, S., Saneha, C., Puwarawuttipanit, W., & Danchaivijitr, P. (2021). Factors predicting chemotherapy induced peripheral neuropathy in breast cancer patients receiving neurotoxic chemotherapy. Chula Medical Journal, 65(2), 155-163.

Kanda, K., Fujimoto, K., & Kyota, A. (2017). Emotional responses to persistent chemotherapy-induced peripheral neuropathy experienced by patients with colorectal cancer in Japan. Asia-Pacific Journal of Oncology Nursing, 4(3), 233-240.

Kleckner, I., Jusko, T., Culakova, E., Kleckner, A., Asare, M., Inglis, J. E., . . . Mustian, K. M. (2020). Inflammatory and clinical risk factors for CIPN: A nationwide longitudinal study in 143 cancer patients during chemotherapy. Journal of Clinical Oncology, 38(15), 12099-13004.

Lenz, E. R., Pugh, L. C., Milligan, R. A., Gift, A., & Suppe, F. (1997). The middle-range theory of unpleasant symptoms: An update. Advances in Nursing Science, 19(3), 14-27.

Miaskowski, C., Paul, S. M., Mastick, J., Abrams, G., Topp, K., Smoot, B., . . . Levine, J. D. (2018). Associations between perceived stress and chemotherapy-induced peripheral neuropathy and otoxicity in adult cancer survivors. Journal of Pain and Symptom Management, 56(1), 88-97.

Mols, F., Beijers, A. J., Vreugdenhil, G., Verhulst, A., Schep, G., & Husson, O. (2015). Chemotherapy-induced peripheral neuropathy, physical activity and health-related quality of life among colorectal cancer survivors from the PROFILES registry. Journal of Cancer Survivorship, 9(3), 512-522.

Nagaraja, A. S., Sadaoui, N. C., Dorniak, P. L., Lutgendorf, S. K., & Sood, A. K. (2016). SnapShot: Stress and disease. Cell Metabolism, 23(2), 388-388.

Napaporn, W., Suchada, P., Jare, W., Budsara, P., Sanchon, K., Roy, B., & Richard, O. (2014). Health literacy. Health Systems Research Institute.

Oken, M. M., Creech, R. H., Tormey, D. C., Horton, J., Davis, T. E., McFadden, E. T., & Carbone, P. P. (1982). Toxicity and response criteria of the Eastern Cooperative Oncology Group. American journal of clinical oncology, 5(6), 649-656.

Ottaiano, A., Nappi, A., Tafuto, S., Nasti, G., De Divitiis, C., Romano, C., . . . Iaffaioli, V. R. (2016). Diabetes and body mass index are associated with neuropathy and prognosis in colon cancer patients treated with capecitabine and oxaliplatin adjuvant chemotherapy. Oncology, 90(1), 36-42.

Papadakos, J. K., Hasan, S. M., Barnsley, J., Berta, W., Fazelzad, R., Papadakos, C. J., . . . Howell, D. (2018). Health literacy and cancer self-management behaviors: A scoping review. Cancer, 124(21), 4202-4210.

Postma, T. J., Aaronson, N. K., Heimans, J. J., Muller, M. J., Hildebrand, J. G., Delattre, J. Y., . . . EORTC Quality of Life Group. (2005). The development of an EORTC quality of life questionnaire to assess chemotherapy-induced peripheral neuropathy: The QLQ-CIPN20. European journal of cancer, 41(8), 1135-1139.

Prasertsri, N., Teeyapan, W., Leavngsomnopa, Y., Wamalun, C. (2015). Nurse’s role in caring of chemotherapy-induced peripheral neuropathy patients. Nursing Journal of The Ministry of Public Health, 25(3), 1-13.

Pulvers, J. N., & Marx, G. (2017). Factors associated with the development and severity of oxaliplatin-induced peripheral neuropathy: A systematic review. Asia-Pacific Journal of Clinical Oncology, 13(6), 345-355.

Rohrl, K., Guren, M. G., Smastuen, M. C., & Rustoen, T. (2019). Symptoms during chemotherapy in colorectal cancer patients. Supportive Care in Cancer, 27(8), 3007-3017.

Silpakit, O. (2008). Srithanya stress scale. Journal of Mental Health of Thailand, 16(3), 177-185.

Soveri, L. M., Lamminmaki, A., Hanninen, U. A., Karhunen, M., Bono, P., & Osterlund, P. (2019). Long-term neuropathy and quality of life in colorectal cancer patients treated with oxaliplatin containing adjuvant chemotherapy. Acta Oncologica, 58(4), 398-406.

Trongakul, S., Lambert, R., Clark, A., Wongparan, N., & Cross, J. (2015). Development of the Thai version of mini-cog, a brief cognitive screening test. Geriatrics and Gerontology International, 15(5), 594-600.

United Nations Economic Commission for Europe. (2019). 2018 Active ageing index. Retrieved from https://www.unece.org/populations/publications/active-ageing-index-analytical-report

World Health Organization. (2020). Global cancer observatory. Retrieved from https://gco.iarc.fr

Yoon, Y. J., & Park, J. S. (2019). Factors influencing peripheral neuropathy of cancer patients undergoing chemotherapy. Asian Oncology Nursing, 19(2), 71-80.

Zajaczkowska, R., Kocot, K. M., Leppert, W., Wrzosek, A., Mika, J., & Wordliczek, J. (2019). Mechanisms of chemotherapy-induced peripheral neuropathy. International journal of molecular sciences, 20(6), 1451-1480.