Effects of an exercise program on perceived self-efficacy and chronic chemotherapy induced peripheral neuropathy among cancer patients receiving FOLFOX chemotherapy
Keywords:
chemotherapy, exercise program, chemotherapy-induced peripheral neuropathyAbstract
This quasi-experimental study aimed to investigate the effects of an exercise program on perceived self-efficacy and chronic chemotherapy-induced peripheral neuropathy (CIPN) in cancer patients receiving FOLFOX chemotherapy regimen which including 5-fluorouracil, oxaliplatin and leucovorin. The sample consisted of 32 cancer patients receiving FOLFOX, who were admitted to a tertiary hospital in the Northeast region of Thailand. They were divided into two groups: 16 patients in the experimental group and 16 in the control group. The study was conducted from July to December 2023. The research tools included: an assessment of perceived self-efficacy in exercise among cancer patients and an assessment of chronic CIPN. The content validity of these tools was evaluated by five experts, yielding a content validity index (CVI) of 1.00 for both assessments. The inter-rater reliability scores were 0.90 and 0.94, respectively. The experimental intervention was an exercise program using videos designed to reduce CIPN, based on Bandura’s self-efficacy theory. The content validity of the program was confirmed by five experts, with a CVI of 1.00. Two-way repeated measures ANOVA was used to compare difference.
The results revealed that the exercise program significantly improved the experimental group’s perceived self-efficacy in exercise compared to the control group, with a large effect size (=0.470; p<.001). Additionally, the experimental group showed significantly lower chronic CIPN symptoms than the control group, with a moderate effect size (
=0.196; p=.004).
The findings of this study suggested that muscle strengthening exercises, muscle and joint stretching exercises, and balance exercises combined with video media can enhance patients’ perceived self-efficacy in exercise and reduce symptoms of CIPN.
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