Effectiveness of Health-Management Program for Delayed Progression of Nephropathy in Patients with Type 2 Diabetes Mellitus : Systematic Review and meta-analysis

Main Article Content

Suwattana Onprasonk


This study was aimed to synthesize the effectiveness of Health-Management Program for Delayed Progression of Nephropathy in Patients with Type 2 Diabetes Mellitus : Systematic Review and meta-analysis. The electronics databases of Cochrane Library ,Pub-Med, Science Direct, Google scholar, TCI, ThaiList and Hand searching from Thai-Journal Citation Index Centre. Published from January 1, 2013 to December 31, 2017 were searched. The randomised or quasi-randomised trials were included. Two review authors independently screened studies based on the pre-specified inclusion criteria, extracted data, and assessed the studied risk of bias. Any disagreement between the reviewers was resolved through discussion. Seven studies were included, with two randomized controlled trials and five quasi-experimental study. All studies were assessed as at high risk of bias. The result revealed that after using intervention program the clinical outcomes (FBS, HbA1c, eGFR, UACR) between control group and experimental group did not difference. Effect of Health-Management Program for Delayed Progression of Nephropathy in Patients with Type 2 Diabetes Mellitus remains unclear.  


Download data is not yet available.

Article Details

How to Cite
Onprasonk S. Effectiveness of Health-Management Program for Delayed Progression of Nephropathy in Patients with Type 2 Diabetes Mellitus : Systematic Review and meta-analysis. jdpc7kk [Internet]. 2019Dec.26 [cited 2020Sep.29];26(3):96-107. Available from: https://he01.tci-thaijo.org/index.php/jdpc7kk/article/view/184886
Research Article


1.International Diabetes Federation (IDF). IDF Diabetes Atlas seventh edition. 2017 [Internet]. [cited 2018 Apr 1]. Available from : http://www.idf. org/diabetesatlas
2. MacIsaac RJ, Ekinci EI, Jerums G. (2014). Markers of and risk factors for the development and progression of diabetic kidney disease. Am J Kidney Dis. 2014; 63:S39-62.
3. American Diabetes Association. Nephropathy in diabetes. Diabetes care. 27:s79-83.
4.Health information system development office (2557). The report of the Thai public health survey by the 5th physical examination 2013-2014. Bangkok: Ministry of Public Health. 2004.
5.International Health Policy Program. Report on disease and injury burden of Thai population 2014. Nonthaburi : The Graphico Systems Company Limited. 2560.
6.Pornpen Srisawasdi. Glycated hemoglobin standardization. Journal of the Medical Technologist Association of Thailand 2550; 35(1): 63-66.
7.Ohkubo, Y., Kishikawa, H., Araki, E., Miyata, T., Lsami, S., Motoyoshi, S., …Shichiri, M. Intensive insulin therapy prevents the progression of diabetic microvascular complications in Japanese patients with noninsulin dependent diabetes mellitus: A randomized prospective 6 year study. Diabetes research and clinical practice 1995; 28: 103-117.
8.United States Renal Data System. Annual data report: Volume one: Atlas chronic kidney disease in the United States. 2009. [Internet]. [cited 2018 Apr 1]. Available from http://www.usrds.org
9.Thai Renal Replacement Therapy committee. Thailand renal replacement therapy year 2009. [Internet]. [cited 2018 Apr 1]. Available from from
10.Shah IM, Mackay SP, McKay GA. Therapeutic strategies in the treatment of diabetic nephropathy - a translational medicine approach. Curr Med Chem. 2009; 16:997-1016.
11.Li T, Wu HM, Wang F, Huang CQ, Yang M, Dong BR, LiuGJ. Education programmes for people with diabetic kidney disease. 2010 [Internet]. [cited 2018 Apr 1]. Available from
12.Diabetes Association of Thailand under The Patronage of Her Royal Highness Princess Maha Chakri Sirindhorn, Department of Medical Services, and National Health Security Office Clinical Practice Guideline for Diabetes. Bangkok: Sri Muang Printing. 2555.
13.Mendelay Ltd. Mendelay Desktop [Computer program] version
14.Higgins JP, Altman DG, Sterne JA. Assessing risk of bias in included studies. In Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0 [Internet]. The Cochrane Collaboration. 2011; Pp.8.1-8.53.[cited 2018 Apr 1]. Available from: http://www.cochrane-handbook.org.
15.The Cochrane Collaboration. Review Manager (RevMan) [Computer program] version 5.3. Copenhagen: The Nordic Cochrane Centre. 2014.
16. Malinee Laopaiboon, Pisake Lumbiganon. Research synthesis in healthcare. Khon Kaen: Department of Biostatistics and Demography Faculty of Public Health Khonkaen University. 2552.
17. Songkran Boonprabang, Nongnut Oba, and Viruch Sirigulsatien. Effects of Protection Motivation Program on Health Behaviors and Glomerular Filtration Rate among Elders with Type 2 Diabetes. Journal of Nursing and Health Sciences 2560; 11(1): 38-48.
18. Apinya Muangkum, Siritree Suttajit. Effects of Patient Empowerment on Self-efficacy, Adherence and Glycemic Control in Patients with Type 2 Diabetes.Thai Pharmaceutical and Health Science Journal 2556; 8(3): 104-111.
19.Siriluk Thungtong, Tippamas Chinnawong, Ploenpit Thaniwattananon. Effects of Self-Management Support Program for Delayed Progression of Diabetic Nephropathy on Self-Management Behaviors and Clinical Outcomes in Patients with Uncontrolled Type 2 Diabetes Mellitus. Songklanagarind Journal of Nursing , 2558; 35(1): 67-84.
20. Pagels A.A., Hylander B., Alvarsson M. A multi-dimensional support programme for patients with diabetic kidney disease. Journal of Renal Care 2015; 41(3): 187–194.
21. Abbasi, B., Ghiasvand, R., Mirlohi, M. Kidney Function Improvement by Soy Milk Containing Lactobacillus plantarum A7 in Type 2 Diabetic Patients With
Nephropathy. Iranian Journal of Kidney Diseases 2017; 11(1): 36-43.
22. Taghizadeh, M. Metabolic Response to Mulberry Extract Supplementation in Patients With Diabetic Nephropathy. Iranian Journal of Kidney Diseases 2017; 11(6): 438-446.
23. Kazawa, K., Takeshita, Y., Yorioka, N., Moriyama, M. Efficacy of a disease management program focused on acquisition of self-management skills in pre-dialysis patients with diabetic nephropathy: 24 months follow-up. J Nephrol 2015; 28: 329-338.