Incidence of hepatitis B and C virus in new cases of hepatocellular carcinoma patients attending at National cancer institute

Abstract

Several factors have been described to be the causative agent of hepatocellular carcinoma (HCC). It has been found that HCC is associated with hepatitis B virus (HBV) or hepatitis C virus (HCV) infection. Infections with HBV or HCV are considered to be a major health problem. Therefore, the aims of this study were to find out the incidence of hepatitis B and C virus-related hepatocellular carcinoma in new cases of patients attending at the national cancer institute during the years 2007-2009. Of 119 HCC cases, 92 (77.3 %) were male and 27 (22.7 %) were female. When comparing among age groups, highest incidence was found in 50-59 years of age which accounted for 33.6 % with an average of 56.8 years. It was found that 58 out of 119 (48.7 %) gave positive result with HBS-Ag. Of 48 available HCC cases for anti-HCV detection, 13 (27.1 %) gave positive results with anti-HCV. When compared between genders, male with HCC was the highest group that gave positive results with HBS-Ag and anti-HCV with 50% and 33.3%, respectively. It was also found that the patient with 50-59 years of age with the average of the age of 54.2 and 55.7 was the highest group that gave positive result with HBS-Ag and anti-HCV with 38.0% and 38.4%, respectively. In addition, a trend towards HCC with HBV infection was found to be lower than previous study with a statistically significant difference (P < 0.0001). And also, significant difference was found (P = 0.0191) when compared HCC with HCV infection with previous study. Taken together, the incidence of HCC-related HBV and HCC-related HCV could be useful for the prevention and control of HBV and HCV infection and pave the way for the detection of an early stage of HCC in population at risk.