Multiple genotype infection of human papilloma virus is associated with cervical cytological abnormalities
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Abstract
Development of cervical cancer is associated with persistent infection of human papillomavirus (HPV). The present study is aimed to determine the association of HPV infection and cervical cytological abnormalities. HPV genotypes and liquid-based cytological analyses were performed 351 cervical brush samples obtained from women visited Gynecology Clinic, Khon Kaen Hospital, Khon Kaen, Thailand. HPV was detected in 23.36% (82/351) of the cases. Among the HPV positive case, 71.95% (59/82) was found with single infection and 28.05% (23/82) were with multiple infections. Of 351 tested specimens, 7.6% (27/351) were presented with abnormal cytology, and 62% (17/27) of these 27 cases were found to positive for HPV. The cytological anomalies presented in HPV positive cases were 52.94% (9/17) of ASCUS, 28.41% (5/17) of LSIL and 17.64% (3/17) of HSIL. Our data showed that cytological abnormalities were more frequently observed in patients with multiple HPV infection, comparing to those with single infection (P < 0.001). However, among the patients with single HPV infection, cytological data were not different between patients with high-risk HPV (HR-HPV) and low-risk HPV(LR-HPV). In conclusion, our present study revealed the association between multiple HPV infection and cervical cytological abnormalities. This information emphasizes the important of HPV genotype analysis for cervical cancer screening and surveillance, those women with multiple HPV infection are strongly suggested to be treated and frequently followed up.
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