Cognitive function and arterial stiffness in overweight and obese diabetes compared with non-obese diabetes individuals
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Abstract
Arterial stiffness is commonly observed in type 2 diabetes (T2DM) patients and may explain the cognitive dysfunction. Obesity is associated with T2DM; however, the additive effects of overweight and obesity on
cognitive function and arterial stiffness have not been investigated. The aim of this study was to determine whether the concomitance of obesity and T2DM cause a further impairment of arterial stiffness and cognitive
function. Arterial stiffness and cognitive function were measured in sedentary healthy subjects, T2DM with normal body mass index and T2DM with obesity patients. Carotid- femoral pulse wave velocity (cfPWV) and
brachial ankle PWV (baPWV), measures of central arterial stiffness, were higher (p-value < 0.05) in diabetes with obesity and diabetic patients than in sedentary controls. There was no difference in central and peripheral arterial stiffness between normal weight and obese T2DM groups. The Montreal Cognitive Assessment (MOCA) score was higher (p-value < 0.05) in diabetes with obesity than in diabetic patients and sedentary controls. In conclusion, diabetes with obesity showed the cognitive function higher than diabetic patient with normal weight. The level of arterial stiffness was not related to cognitive function in diabetic with obesity patients.
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