Anemia and thalassemia in the Kui (Suay) elderly living in Sisaket Province located at the lower Northeastern Thailand

Main Article Content

Roongnalin Bunthupanich
Rossarin Karnpean
Anuwat Pinyachat
Nawinda Jiambunsri
Nattapol Prakobkaew

Abstract

This study investigated the prevalence of anemia and thalassemia in Suay elderly population. The study conducted on 63 apparently healthy individuals with age of 60-85 years.  Blood samples were collected to determine the following laboratory testings; red blood cell (RBC) parameters, hemoglobin analysis and globin genotyping. Based upon established WHO criteria, the overall prevalence of anemia was found to be 47.6%. The astoundingly high prevalence of thalassemia was found in non-anemic subjects for 84.8% and anemic subjects for 93.3%. As expected, the high frequency of Hb E and +-thalassemia was observed in this population, consistent with the evidence previously known in the region.  High prevalence of 0-thalassemia (SEA deletion) was found in Suay ethnic group. In addition, -thalassemia and Hb E relateddisease like AEBart’s and EEBart’s were found in this population. These data indicated that health burden resulting from Hb Bart’s hydrops fetalis may be serious in Suay ethnic group and complex thalassemia disease found to be health problems in the elderly. Our findings provide not only baseline information, potentially useful for implementing appropriate control measures, but also an enhanced awareness and understanding of anemia and health care advice among Suay elderly population.

Article Details

How to Cite
1.
Bunthupanich R, Karnpean R, Pinyachat A, Jiambunsri N, Prakobkaew N. Anemia and thalassemia in the Kui (Suay) elderly living in Sisaket Province located at the lower Northeastern Thailand. Arch AHS [Internet]. 2020 Dec. 29 [cited 2024 May 21];32(3):32-8. Available from: https://he01.tci-thaijo.org/index.php/ams/article/view/239930
Section
Original article

References

1. Blanc B, Finch CA, Hallberg L, Lawkowicz W, Layrisse M, Mollin DL, et al. Nutritional Anaemias. Report of a WHO Scientific Group. World Health Organization, Technical Report Series. Geneva: World Health Organization, 1968:40.
2. Cheng CK, Chan J, Cembrowski GS, van Assendelft OW. Complete blood count reference interval diagrams derived from NHANES III: stratification by age, sex, and race. Lab Hematol. 2004; 10(1):42-53.
3. Zakai NA, Katz R, Hirsch C, Shlipak MG, Chaves PHM, Newman AB, et al. A Prospective Study of Anemia Status, Hemoglobin Concentration, and Mortality in an Elderly Cohort: The Cardiovascular Health Study. Arch Intern Med. 2005; 165(19):2214-20.
4. McLean E, Cogswell M, Egli I, Wojdyla D, de Benoist B: Worldwide prevalence of anaemia, WHO vitamin and mineral nutrition information system, 1993–2005. Public Health Nutr 2009; 12: 444-54.
5. Lasch KF, Evans CJ, Schatell D: A qualitative analysis of patient-reported symptoms of anemia. Nephrol Nurs J 2009; 36: 621-44.
6. Evatt BL, Gibbs WN, Lewis SM, McArthur JR: Fundamental Diagnostic Hematology: Anemia, ed 2. Geneva, World Health Organization, 2002.
7. Pansuwan A, Fuchareon G, Fuchareon S, Himakhun B, Dangwiboon S. Anemia, iron deficiency and thalassemia among adolescents in Northeast Thailand: results from two independent surveys. Acta Haematol 2011; 125: 186-92.
8. Panomai N, Sanchaisuriya K, Yamsri S, Sanchaisuriya P, Fucharoen G, Fucharoen S, Schelp FP. Thalassemia and iron deficiency in a group of northeast Thai school children: relationship to the occurrence of anemia. Eur J Pediatr. 2010; 169: 1317-22.
9. Thurlow RA, Winichagoon P, Green T, Wasantwisut E, Pongcharoen T, Bailey KB, Gibson RS. Only a small proportion of anemia in northeast Thai schoolchildren is associated with iron deficiency. Am J Clin Nutr 2005; 82: 380–387.
10. Sanchaisuriya K, Fucharoen S, Ratanasiri T, Sanchaisuriya P, Fucharoen G, Dietz E, Schelp FP. Thalassemia and hemoglobinopathies rather than iron deficiency are major causes of pregnancy-related anemia in northeast Thailand. Blood Cells Mol Dis 2006; 37: 8-11.
11. Deeruksa L, Sanchaisuriya K. Anemia in the elderly in Northeastern Thailand: A community based study investigating prevalence, contributing factors, and hematologic features. Acta Haematologica 2017; 138: 96-102.
12. Deeruksa L, Raksasang M, Sanchaisuriya K. Anemia, Iron Deficiency and Iron Deficiency Anemia in a Group of Hill-Tribe, Pakakayo-Karen. KKU Journal for Public Health Research 2018; 11(1): 18-27.
13. Smith, Kenneth D. 1983. A Lexico-Statistical study of Mon-Khmer language. In: A. Gonzalez and D. Thomas, eds., Linguistics across continent. Manila: Linguistic society of the Philippines 1983; 180-205
14. National Statistical Office, The 2000 Population and Housing Census: the Whole Kingdom, Bangkok, 2002: Population Table VII.
15. Fucharoen G, Fucharoen S, Sanchaisuriya K, Sae-Ung N, Suyasunanond U, Sriwilai P, Chinorak P. Frequency Distribution and Haplotypic Heterogeneity of beta(E)-Globin Gene among Eight Minority Groups of Northeast Thailand. Hum Hered. 2002; 53(1): 18-22
16. Iron deficiency anemia: assessment, prevention and control. A guide for program managers. Document WHO/NHD/01.3. Geneva, World Health Organization, 2001.
17. Sae-ung N, Fucharoen G, Sanchaisuriya K, Fucharoen S. α0-Thalassemia and related disorders in northeast Thailand: a molecular and hematological characterization. Acta Haematol 2007; 117(2): 78-82.
18. Charoenwijitkul T, Singha K, Fucharoen G, Sanchaisuriya K, Thepphitak P, Wintachai P, Karnpean R, Fucharoen S. Molecular characteristics of α+-thalassemia (3.7 kb deletion) in Southeast Asia: Molecular subtypes, haplotypic heterogeneity, multiple founder effects and laboratory diagnostics. Clin Biochem. 2019; 71: 31-7.
19. Fucharoen S, Fucharoen G, Fukumaki Y. Simple non-radioactive method for detecting haemoglobin Constant Spring gene. Lancet 1990; 335(8704): 1527.
20. Sanchaisuriya K, Fucharoen G, Fucharoen S. Hb Paksé [(α2) codon 142 (TAA→TAT or Term→Tyr)] in Thai patients with EAbart’s disease and Hb H disease. Hemoglobin 2002; 26(3): 227-35.
21. Guralnik JM, Eisenstaedt RS, Ferrucci L, Klein HG, Woodman RC: Prevalence of anemia in persons 65 years and older in the United States: evidence for a high rate of unexplained anemia. Blood 2004; 104: 2263-8.
22. Choi CW, Lee J, Park KH, Yoon SY, Choi IK, Oh SC, Seo JH, Kim BS, Shin SW, Kim YH, Kim JS: Prevalence and characteristics of anemia in the elderly: cross-sectional study of three urban Korean population samples. Am J Hematol 2004; 77: 26-30.
23. Yamada M, Wong FL, Suzuki G: Longitudinal trends of hemoglobin levels in a Japanese population – RERF’s Adult Health Study subjects. Eur J Haematol 2003; 70: 129-35.
24. Wang JL, Shaw NS: Iron status of the Taiwanese elderly: the prevalence of iron deficiency and elevated iron stores. Asia Pac J Clin Nutr 2005; 14: 278-84.
25. Denny SD, Kuchibhatla MN, Cohen HJ: Impact of anemia on mortality, cognition, and function in community-dwelling elderly. Am J Med 2006; 119: 327-34.
26. Carnley BP, Prior JF, Gilbert A, Lim E, Devenish R, Sing H, Sarin E, Guhadasan R, Sullivan SG, Wise CA, Bittles AH, Chan K, Wong MS, Chan V, Erber WN: The prevalence and molecular basis of hemoglobinopathies in Cambodia. Hemoglobin 2006; 30: 463-70.
27. Tritipsombut J, Sanchaisuriya K, Phollarp P, Bouakhasith D, Sanchaisuriya P, Fucharoen G, et al. Micromapping of thalassemia and hemoglobinopathies in different regions of Northeast Thailand and Vietaine, Laos People’s Democratic Republic. Hemoglobin 2012; 36: 47-56.