Association of alpha fibrinogen -58G/A genetic polymorphisms with acute coronary syndrome in type 2 diabetes mellitus

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Published: Dec 29, 2020
Keywords:
Fibrinogen Polymorphism Diabetes mellitus Acute coronary syndrome

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Chananikan Makmool
Biomedical Sciences Program, Graduate School, Khon Kaen University, Khon Kaen, Thailand.; Cardiovascular Research Group, Khon Kaen University, Khon Kaen, Thailand.
Nantarat Komanasin
Cardiovascular Research Group, Khon Kaen University, Khon Kaen, Thailand.; School of Medical Technology, Faculty of Associated Medical Sciences, Khon Kaen University, Khon Kaen, Thailand.
Burabha Pussadhamma
Cardiovascular Research Group, Khon Kaen University, Khon Kaen, Thailand.; Department of Medicine, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand.
Wit Lueangwattananon
Queen Sirikit Heart Center of the Northeast, Khon Kaen University, Khon Kaen, Thailand.

Abstract

Fibrinogen is one of the inflammatory markers and plays a crucial role in pathophysiological process of cardiovascular diseases (CVD).  High levels of fibrinogen are associated with atherosclerosis progression and CVD complication in type 2 diabetes mellitus (DM). Furthermore, fibrinogen genetic polymorphisms are one of the important factors affecting their levels. Therefore, this study aimed to evaluate the associations of FGA -58G/A polymorphism with clinical manifestations of coronary artery disease (CAD) in type 2 DM. A case-control study included 123 documented DM patients presenting with either acute coronary syndrome (ACS) or stable CAD and 86 control individuals without DM and presenting none or less than 50% stenosis of coronary artery. All subjects were genotyped for the FGA -58G/A polymorphism by using polymerase chain reaction-restriction fragment length polymorphism technique. The results showed that AA genotype and A allele of the FGA -58G/A polymorphism were independently associated with DM [adjusted OR (95% CI) = 3.3 (1.2, 8.9) and 3.3 (1.6, 6.6), respectively]. Moreover, the AA genotype and A allele were also significantly associated with ACS in diabetic patients [adjusted OR (95% CI) = 3.9 (1.3, 11.7) and 2.0 (1.2, 3.5), respectively], while the association with stable CAD was not observed. In conclusion, the results of this study may indicate the association of the FGA -58G/A polymorphism with the atherosclerotic progression which may in turn leads to the severe clinical manifestation of CAD in DM.

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Makmool C, Komanasin N, Pussadhamma B, Lueangwattananon W. Association of alpha fibrinogen -58G/A genetic polymorphisms with acute coronary syndrome in type 2 diabetes mellitus. Arch AHS [Internet]. 2020 Dec. 29 [cited 2024 Dec. 19];32(3):50-7. Available from: https://he01.tci-thaijo.org/index.php/ams/article/view/205694
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Vol. 32 No. 3 (2020): September - December
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Original article
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