260 例支气管扩张症患者的中医证候规律调查研究

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张 正易
樊 雅欣
柏 萍
苏 奔
张 少言
吴 定中
郑 培永
鹿 振辉
邱 磊

摘要

目的本研究为探讨支气管扩张患者的中医证素和证型分布规律。方法将集 2020 年 5 月至 2022 年 1 月上海中医药大学附属龙华医院门诊和住院支气管扩张患者 260 例的中医证素证候信息和临床资料,分析中医证素证候分布及不同证候中其临床分期,近一年急性加重次数,身体质量指数(BMI,Body Mass Index)和微生物定植的差异。结果该病在人群中的主要病位证素集中于肺 257 例(98.85%),其次分别为为肾(16.54%)、心(7.69%)、脾(7.31%)和肝(7.31%);病性证素中痰出现的频率最高为 152 例(58.46%),其次为阴虚(45.77%),气虚(41.15%)和火(22.69%)。证素组合中,以肺合并气虚最多,共 39 例(15.00%),证型分布中实证占 90 例(34.62%),虚症占 100 例(38.46%),虚实夹杂占 79 例(30.38%)。以证素组合构成证型,260 例病例中实证共 90 例(34.62%),虚证共 100 例(38.46%),虚实夹杂证共 70 例(26.92%)。中医证型分布最多的分别为痰热壅肺证 53 例(20.38%),肺气虚证 34 例(13.08%)和肺气阴两虚证 32 例(12.31%)。结论支气管扩张患者证素分布广泛,证型虚实夹杂,且与不同证型的患者其临床特征差异较大。

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参考

Lin JL, Xu JF, Qu JM. Bronchiectasis in China. Ann Am Thorac Soc. 2016;13(5):609-16.

Cai BQ, He QY, Gao ZC, Cao ZL, Ma YL, Yang RH, et al. Expert consensus on the diagnosis and treatment of bronchiectasis in adults. Chinese Journal of Critical Care Medicine (Electronic Edition). 2012;5(5):315-28. (in Chinese)

Hill AT, Sullivan AL, Chalmers JD, De-Soyza A, Elborn JS, Floto AR, et al. British Thoracic Society guideline for bronchiectasis in adults. Thorax. 2019;74(1):1-69.

Li JS, Wang ZW, Xie Y, Chun L. Diagnostic criteria of bronchiectasis for traditional Chinese medicine syndromes (2019 edition). J Tradit Chin Med. 2020;61(15):1377-80. (in Chinese)

Yan ZQ, Xu YF, Li KK, Xu YQ, Hu JX, Xiao H, et al. Hong Guang Xiang, a master of traditional Chinese medicine, discussed the experience of treating bronchiectasis in remission from the perspective of "replenishing deficiency and laxative, and treating the lungs and spleen at the same time". Lishizhen Medicine and Materia Medica Research. 2023;34(8):1997-9. (in Chinese)

Wang AA, Wang ZR, Huang WL, Pan WR, Ma CY, Li YL, et al. Discussion on the treatment of bronchiectasis based on the theory of incubative pathogenic factors. Chinese Journal of Information on Traditional Chinese Medicine. 2024;31(2):173-6. (in Chinese)

Li JS. Summary of TCM syndrome differentiation and treatment of bronchiectasis. Acta Chinese Medicine. 2017;32(10):1867-9. (in Chinese)

Yang S, Zhang WR, Ma ZJ, Huang Y. Distribution of TCM syndrome elements and syndrome types of bronchiectasis in remission stage based on literature research. Guiding Journal of Traditional Chinese Medicine and Pharmacy. 2019;25(13):16-8. (in Chinese)

Fu L. Distribution of traditional Chinese medical syndrome elements and syndrome types of bronchiectasis. Journal of Guangzhou University of Traditional Chinese Medicine. 2016;33(3):310-3. (in Chinese)

Wang P, Zhai T, Wang HX, Huang DH. Analysis of TCM syndrome factor distribution, etiological characteristics and disease-related influencing factors in acute exacerbation of bronchiectasis. Journal of Emergency in Traditional Chinese Medicine. 2023:32(8):1373-7. (in Chinese)

Xie SY, Zhao W. Chen Shao Hong, a master of traditional Chinese medicine, based on the clinical experience of "golden depression and dryness" in the treatment of bronchiectasis with hemoptysis. Yunnan Journal of Traditional Chinese Medicine and Materia Medica. 2023;44(8):1-4. (in Chinese)

Chen JL, Liang AW, Li Y, Luo XR, Wu GZ, Huang RY. Exploration of therapeutic thoughts for concurrently regulating lung and spleen in bronchiectasis. Guangxi Medical Journal. 2022;44(16):1925-7. (in Chinese)

Li H, Zhou QW, Cui QR. Based on the lungs, spleen and kidneys, the "common cause general method" was used to identify and treat bronchiectasis. China's Naturopathy. 2020;28(2):1-3. (in Chinese)

Solarat B, Perea L, Faner R, de La Rosa D, Martínez García MÁ, Sibila O. Pathophysiology of chronic bronchial infection in bronchiectasis. Arch Bronconeumol. 2023;59(2):101-8.

Xin DY, Di HR. Experience discussion on treating bronchiectasis through phlegm of Liu Fang Bai. Journal of Sichuan of Traditional Chinese Medicine. 2021;39(6):1-4. (in Chinese)

Shi DL, Li SY, Wang ZW, Cai KK. Research on the treatment of bronchiectasis from phlegm. Traditional Chinese Medicinal Research. 2019;32(2):5-8. (in Chinese)

Zhang MF, Liu CX, Zhan SF, Huang HT, Liu XH, Jiang Y, et al. Clinical efficacy of modified Weijing decoction in the treatment of acute exacerbation of bronchiectasis with syndrome of phlegm-heat obstructing lung. Journal of Emergency in Traditional Chinese Medicine. 2023;32(12):2161-4. (in Chinese)

Qi HQ, Huang WM, Li H. Qian Jin Wei Jing decoction combined with phentolamine for the treatment of bronchiectasis efficacy and its effects on serum indexes and immune function of patients. Tianjin Journal of Traditional Chinese Medicine. 2023;40(11):1371-6. (in Chinese)

Qiu L, Yang XY, Chen JJ, Zhang SY, Wu DZ, Zhang HY, et al. Observation on curative effect of Sangbaipi decoction combined with routine western medicine in treating bronchiectasis with phlegm-heat obstructing lung syndrome. Beijing Journal of Traditional Chinese Medicine. 2023;42(8):819-23. (in Chinese)

Qiu L, Xu H, Yang XY, Pan CH, Zhang SY, Wu XW, et al. Discussion on the potential mechanism Sangbaipi decoction in the treatment of bronchiectasis based in network pharmacology. Journal of Practical Traditional Chinese Internal Medicine. 2023;37(7):9-12. (in Chinese)

Yu LT, Luo TT, Guo ZB, Gao ZX. Shen Zhu Yang Fei decoction combined with cough and asthma patch to treat lung, spleen an qi deficiency in bronchiectasis 56 cases. Global Traditional Chinese Medicine. 2021;14(5):968-71. (in Chinese)