Advances in dual regulation of atherosclerotic pathways by perivascular adipose tissue
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Abstract
Atherosclerosis (AS) is formed due to complex interactions between vascular cells and inflammatory factors. During the development of AS, perivascular inflammatory factors are closely associated with perivascular adipose tissue (PVAT), which regulates the development of AS through the secretion of different factors, and the brown adipose tissue it contains may have a positive regulatory effect on AS. Therefore, activating PVAT and browning it may be a new target for the treatment of cardiovascular diseases such as AS. A variety of Chinese herbal medicine active ingredients and compounds have been found to promote adipose tissue browning. In this paper, we review the pathways of PVAT dual regulation of AS and the progress of adipose tissue browning research.
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