Antibiogram in cancer patients
Keywords:
Antibiogram, Antimicrobial resistance, cancerAbstract
Antibiogram is an important data regarding to antimicrobial selection during microbial culture procedure (empirical therapy). This data can be use to monitoring trends of antimicrobial resistance in hospital. The objective of this retrospective study is to monitoring trend of antimicrobial resistance among bacterial pathogens in cancer patients at The National Cancer Institute during 2019 - 2021. Data were analyzed by descriptive statistical method which are 95% Confidence interval , Odds ratio and Chi-square test. The data of culture and sensitivity test in microbiology laboratory which specimen were urine, sputum, pus, body fluid and blood culture found 2,100 isolations. Top 5 of common isolations were E. coli (23%), P. aeruginosa (12%) followed by K. pneumoniae (11%) Enterococcus spp.(7%) and Acinetobacter spp (4%). E. coli were susceptible to carbapenem, TZP and AN mostly 90% and trend of antimicrobial sensitivity to AMC and GM were increase significantly (OR; 1.77, 95%CI; 1.10 - 2.87, P=0.019) and (OR; 2.61 95%CI; 1.59– 4.28, P< 0.001) respectively. P. aeruginosa were susceptible to CT mostly 99% and trend of antimicrobial to IPM were increase significantly (OR; 2.42 95%CI; 1.23 - 4.75, P=0.010). K. pneumoniae were susceptible to AN mostly 90% and trend of antimicrobial resistant significant to CAZ, CTX, CRO, FEP, DOR, IPM, MEM, CIP and SXT were decrease (OR; 0.3 - 0.4, 95%CI; 0.23-0.91, 0.24-0.94, 0.20-0.80, 0.21-0.86, 0.12-0.98, 0.21-1.24,0.21-1.24,0.23-0.89, 0.23 - 0.91 respectively, P<0.05). Enterococcus spp were susceptible to VA mostly 88% trend of antimicrobial to CIP and E were increase significantly (OR; 3.909, 95%CI; 1.20 - 12.76, P= 0.024) and (OR; 4.929, 95%CI; 1.01 - 24.126, P= 0.049) respectively. In 2021 sensitivity trend to P and AMP decrease (OR;0.385, 95%CI; 0.15 – 0.97, P= 0.042) and (OR;0.309, 95%CI; 0.12-0.81, P= 0.017) respectively. Acinetobacter spp. were suscep- tible to CT mostly 95% and trend of antimicrobial sensitivity to DOR in 2020 - 2021 decrease significantly (OR;0.257, 95%CI; 0.07 - 0.89, P= 0.033) and (OR;0.148, 95%CI; 0.04 – 0.60, P= 0.008) respectively.ฤ
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