Overall survivals of Thai metastatic triple negative breast cancer patients

Abstract

Triple negative breast cancer (TNBC) is poor prognosis type of breast cancer, especially in patients with metastatic diseases. The treatment options for TNBC are quite limited and overall survival (OS) of metastatic TNBC was shorter compare to other types of breast cancer. There are restricted information regarding to OS of metastatic TNBC in Thais. This study was aimed for finding information about OS and factors related with OS in Thai metastatic TNBC patients. We retrospectively reviewed metastatic TNBC patients’chart in one of university hospital in Bangkok. Relevant information of metastatic TNBC patients who were at least 18 years old who received treatments for their cancer during 1 January to 31 December 2012 to 2016 were collected and analyzed. There were 127 patients included in the study. The average age was 54+13.3 years old, with 78% under 65 years old. The most common metastatic sites were bone and connective tissue, which found 66.1%, followed by lungs, liver at 63.8% and 29.1 %, respectively. Most of patients (38.6%) had 2 metastatic sites and around 64.6% received anthracycline-based regimen as the first line treatment. The second most common chemotherapy for the first line treatment were taxane (19.7%). The median OS in this study was 21.9 months. The survival rate at 1 year, 3 years and 5 years were 45.7%, 10.2% and 3.9 % respectively. The factors which found to associated with OS were metastatic sites. Patients with liver, lungs, or bone metastasis had significantly shorter OS. Moreover, older patients (>65 years old) tended to have longer OS (16.7 vs 13.2 months, P = 0.081). Patients treated with taxane as the first line chemotherapy had longer OS with not statistically significance. We conclude that the factors seem to impact overall survival of Thai metastatic TNBC were metastatic sites and patients’age.