Mutations and carcinogenesis
Keywords:
gene mutations, mutations, cancer, carcinogenesisAbstract
There are two types of gene mutations, namely, hereditary gene mutations and somatic mutations. Both types of mutations imposed the risk of developing cancer. However, cancers caused by hereditary mutations are less common, compared to cancers caused by somatic mutations. Association between gene mutations and carcinogenesis has been suggested by several studies on various types of cancer.Examples of some gene mutations associated with the carcinogenesis are H-ras oncogene, insulin-like growth factor-1,vascular endothelial growth factor A gene, telomerase reverse transcriptase gene, retinoblastoma tumor suppressor gene 1, CDH1 gene.The objective of this review article is to provide up-to-date knowledge about the relationship between gene mutations and carcinogenesis.
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