Ruxolitinib for the Treatment of Acute Graft-Versus-Host Disease (aGVHD)

  • Utairat Meeudompong Pharmacy Department, Siriraj Hospital, Bangkok
  • Janjira Kaewla Pharmacy Department, Siriraj Hospital, Bangkok
Keywords: Ruxolitinib aGVHD Steroid refractory

Abstract

Ruxolitinib is a selective Janus Associated Kinase (JAK1 and JAK2) inhibitor indicated for graft-versus-host disease (GVHD). The drug works by dysregulating the JAK-STAT pathway, thereby reducing the incidence and severity of GVHD. It is the only FDA-approved drug for steroid-refractory acute GVHD in patients 12 years and older. The recommended dose is 5 mg orally twice daily, which can be increased to 10 mg twice daily after three days in the absence of toxicity. The overall response rate (ORR), defined as a partial or complete response to therapy, is 62%, and overall survival is 11.1 months. The most common adverse effects are thrombocytopenia, anemia, cytomegalovirus (CMV) infection, peripheral edema, neutropenia, hypokalemia and hypertension.

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Published
2021-05-08
Section
Review Articles