Drug Interaction between Tyrosine Kinase Inhibitors and Antacids

  • Bussaba Trakarnsanga Cytotoxic Compounding Unit, Pharmacy Department, King Chulalongkorn Memorial Hospital, Bangkok, Thailand
Keywords: Cancer targeted therapy antacids drug interactions


In the past decade, Tyrosine kinase inhibitors (TKIs) have been approved as a treatment for hematologic malignancy and several types of cancers. Since then, they have been extensively prescribed due to their convenient route of administration as oral tablets. However, there are some concerns regarding drug-drug interactions, which may affect the efficiency of the treatment. Antacids, which are also prescribed for many cancer patients during treatment, can increase gastric pH and decrease TKIs solubility, bioavailability, and treatment efficacy. The information concerning the uses of TKIs with antacids is still limited, and there is no standard recommendation regarding the combination use of both drugs for cancer treatments. Therefore, this review integrates pharmacological data and results from the combination-use trial to provide a guideline for using both drugs that minimize drug-drug interactions and retain the TKIs treatment's efficiency.


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