Treatment Outcomes and Prognostic Factors for Patients with Soft-tissue Sarcoma at Maharat Nakhon Ratchasima Hospital
Keywords:
soft-tissue sarcoma treatment prognosisAbstract
This 10-year retrospective study aimed to evaluate the outcomes and prognosticfactors for patients with soft-tissue sarcoma at Maharat Nakhon Ratchasima Hospital. An analysis of 236 patients who underwent treatment was conducted with 117 males and 119 females having a mean age of 52.7 years (standard deviation 16.5 years). Of these, 88.6 percent presented with a painless mass, and most tumors (52.1%) were located at the extremities. In terms of stage, 87.3 percent of the patients showed localized cancer.
The tumors were over 5 cm.in size in 80.5% of cases. The three most common pathologies were leiomyosarcoma (16.1%), liposarcoma (14.4%), and dermatofibrosarcoma protuberans (14.4%). The treatments for soft-tissue sarcoma comprised surgery (91.1%), radiation (30.1%), and chemotherapy (12.3%). The overall 3-year and 5-yearsurvival rates were 68.9% and 60.7%, respectively. For localized cancer, the 3-year and 5-year survival rates were 73% and 64.2%, respectively. The metastatic cancer patients had a 3-year survival rate of 39%. The factors that significantly affect survival outcomes were age greater than 60 years (OR=2.42, P<0.01), tumor size larger than 5 cm. (OR=2.34, P=0.02), early stage of the cancer (OR=3.60, P=0.02), and surgical treatment (OR=0.35, P=0.02). These results reaffirm the importance of patient status, early detection of cancer, and curative surgery, which are improving survival outcomes.
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