Prognostic Effects of Cholesterol Levels in Patients with Breast Cancer
Keywords:HDL cholesterol, LDL cholesterol, breast cancer, prognosis, survival
High cholesterol level has been found to be a risk factor for breast cancer. However, few studies have reported on their prognostic impact. This study aimed to determine the effect of cholesterol level on breast-cancer prognosis. Cholesterol levels were detected in 142 cases of breast cancer diagnosed at the National Cancer Institute in 2011-2018. We found that low levels of HDL cholesterol (≤65 mg/dL) were mainly present in breast-cancer patients with lymph-node metastasis (P=0.037) and negative progesterone receptor (P=0.045). However, this study revealed no association between HDL cholesterol level and age, stage, estrogen receptor, P53, Ki67, HER-2 and the overall survival of the patients. Our findings suggested that a low level of HDL cholesterol may correlate with a poor prognosis in breast cancer.(Thai Cancer J 2020;40:86-97)
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