Relationship between Vitamin D and Breast Cancer
Keywords:
vitamin D, breast cancer, single nucleotide polymorphismsAbstract
The relationship between vitamin D and breast cancer risk has been studied by many researchers. There is evidence that vitamin D can induce cell cycle arrest, inhibit cell proliferation, and promote apoptosis, including cell differentiation in breast cancer. Several recent studies have investigated the association between vitamin D-related gene polymorphisms and breastcancer risk. Studies have reported that breast-cancer risk may be associated with specific vitamin Drelated single nucleotide polymorphisms (SNPs). However, studies of the vitamin D pathway genetic variants in relation to breast cancer risk have shown inconsistent results. Some SNPs of vitamin D-related genes were not significantly associated with breast-cancer risk, whereas some SNPs showed an association with breast-cancer risk. The studies also investigated the expression levels of vitamin D-related genes in breast-cancer tissue. The results demonstrated that gene expression of specific vitamin D-related genes may be down-regulated or up-regulated in breast cancer. However, some clinical data on vitamin D-related gene expression in breast cancer are inconsistent, which may be due to the limitations of individual studies or racial and cultural diversity, and habitants. In addition, breast cancer is a heterogeneous disease with different subtypes that exhibit distinct patterns of disease progression.
References
Thakkar A, Wang B, Picon-Ruiz M, Buchwald P, Ince TA. Vitamin D and androgen receptor-targeted therapy for triple-negative breast cancer. Breast Cancer Res Treat 2016;157:77-90.
Mayer IA, Abramson VG, Lehmann BD, Pietenpol JA. New strategies for triple-negative breast cancerdeciphering the heterogeneity, Clin. Cancer Res. Off. J. Am. Assoc. Cancer Res 2014;20:782-90.
Grant WB. 25-Hydroxyvitamin D and breast cancer, colorectal cancer, and colorectal adenomas: casecontrol versus nested case-control studies. Anticancer Res 2015;35:1153-60.
Mohr SB, Gorham ED, Alcaraz JE, Kane CJ, Macera CA, Parsons JK, et al. Serum 25-hydroxyvitamin D and prevention of breast cancer: pooled analysis. Anticancer Res 2011;31:2939-48.
Autier P, Boniol M, Pizot C, Mullie P. Vitamin D status and ill health: a systematic review. Lancet. Diabetes Endocrinol 2014;2:76-89.
Yao S, Ambrosone CB. Associations between vitamin D deficiency and risk of aggressive breast cancer in African-American women. J Steroid Biochem Mol Biol 2013;136:337-41.
Peppone LJ, Rickles AS, Janelsins MC, Insalaco MR, Skinner KA. The association between breast cancer prognostic indicators and serum 25-OH vitamin D levels. Ann Surg Oncol 2012;19:2590-9.
Pendas-Franco N, Gonzalez-Sancho JM, Suarez Y, Aguilera O, Steinmeyer A, Gamallo C, et al. Vitamin D regulates the phenotype of human breast cancer cells. Differentiation 2007;75:193-207.
Hoyer-Henson M, Bastholm L, Mathiasen IS, Elling F, Jaattela M. Vitamin D analog EB1089 triggers dramatic lysosomal changes and Beclin 1-mediated autophatic cell death. Cell Death Differ 2005;12: 1297-309.
Scarmo S, Afanasyeva Y, Lenner P, Koenig KL, Horst RL, Clendenen TV, et al. Circulating levels of 25-hydroxyvitamin D and risk of breast cancer: a nested case-control study. Breast Cancer Res 2013;15:R15.
Kim Y, Je Y. Vitamin D intake, blood 25(OH)D levels, and breast cancer risk or mortality: a meta-analysis. Br J Cancer 2014;110:2772-84.
Wang D, Velez de-la-Paz OI, Zhai JX, Liu DW. Serum 25-hydroxyvitamin D and breast cancer risk: a metaanalysis of prospective studies. Tumour Biol 2013; 4:3509-37.
Kuhn T, Kaaks R, Becker S, Eomois PP, Clavel-Chapelon F, Kvaskoff M, et al. Plasma 25-hydroxyvitamin D and the risk of breast cancer in the European prospective investigation into cancer and nutrition: a nested case-control study. Int J Cancer 2013;133:1689-700.
Kemmis CM, Salvador SM, Smith KM, Welsh J. Human mammary epithelial cells express CYP27B1 and are growth inhibited by 25-hydroxyvitamin D-3, the major circulating form of vitamin D-3. J Nutr 2006;136:887-92.
Segersten U, Holm PK, Bjorklund P, Hessman O, Nordgren H, Binderup L, et al. 25-Hydroxyvitamin D3 1alpha-hydroxylase expression in breast cancer and use of non-1alpha-hydroxylated vitamin D analogue. Breast Cancer Res 2005;7:R980-6.
McCullough ML, Stevens VL, Diver WR, Feigelson HS, Rodriguez C, Bostick RM, et al. Vitamin D pathway gene polymorphisms, diet, and risk of postmenopausal breast cancer: a nested case-control study. Breast Cancer Res 2007;9:R9.
Welsh J, Wietzke JA, Zinser GM, Smyczek S, Romu S, Tribble E, et al. Impact of the Vitamin D3 receptor on growth-regulatory pathways in mammary gland and breast cancer. J Steroid Biochem Mol Biol 2002; 83:85-92.
Jones G, Prosser DE, Kaufmann M. 25-Hydroxyvitamin D-24-hydroxylase (CYP24A1): its important role in the degradation of vitamin D. Arch Biochem Biophys 2012;523:9-18.
Bishop JE, Collins ED, Okamura WH, Norman AW. Profile of ligand specificity of the vitamin D binding protein for 1 alpha,25-dihydroxyvitamin D3 and its analogs J Bone Miner Res 1994;9:1277-88.
Narvaez CJ, Zinser G, Welsh J. Functions of 1 alpha,25-dihydroxyvitamin D(3) in mammary gland: from normal development to breast cancer. Steroids 2001;66:301-08.
Colston K, Welsh J. Vitamin D and breast cancer. in: D. Feldman, J.W. Pike, F.H. Glorieux (eds.), Vitamin D, Second ed. vol. 2. San Diego: Elsevier Academic Press; 2005. P. 1663-77.
Pirianov G, Colston KW. Interactions of vitamin D analogue CB1093, TNFalpha and ceramide on breast cancer cell apoptosis. Mol Cell Endocrinol 2001;172:69-78.
Wang Q, Lee D, Sysounthone V, Chandraratna RAS, Christakos S, Korah R, et al. 1,25-dihydroxyvitamin D3 and retonic acid analogues induce differentiation in breast cancer cells with function- and cellspecific additive effects. Breast Cancer Res Treat 2001;67:157-68.
Krishnan AV, Swami S, Peng L, Wang J, Moreno J, Feldman D. Tissue-selective regulation of aromatase expression by calcitriol: implications for breast cancer therapy. Endocrinology 2010;15:32-42.
Ristimaki A, Sivula A, Lundin J, Lundin M, Salminen T, Haglund C, et al. Prognostic significance of elevated cyclooxygenase-2 expression in breast cancer. Cancer Res 2002;62:632-35.
Krishnan AV, Swami S, Feldman D. Vitamin D and breast cancer: inhibition of estrogen synthesis and signaling. J Steroid Biochem Mol Biol 2010;121:343-8.
Kalniete D, Nakazawa-Miklaševica M, štrumfa I, Abolinš A, Irmejs A, Gardovskis J, et al. High expression of miR-214 is associated with a worse diseasespecific survival of the triple-negative breast cancer patients. Hered Cancer Clin Pract 2015;13:7-13.
Alimirah F, Peng X, Gupta A, Yuan L, Welsh J, Cleary M, et al. Crosstalk between the vitamin D receptor (VDR) and miR-214 in regulating SuFu, a hedgehog pathway inhibitor in breast cancer cells. Exp Cell Res 2016;349:15-22.
McCullough ML, Bostick RM, Mayo TL. Vitamin D gene pathway polymorphisms and risk of colorectal, breast, and prostate cancer. Annu Rev Nutr 2009;29:111-32.
Anderson LN, Cotterchio M, Cole DE, Knight JA. Vitamin D-related genetic variants, interactions with vitamin D exposure, and breast cancer risk among Caucasian women in Ontario. Cancer Epidemiol Biomark Prev 2011;20:1708-17.
Feldman D, Krishnan AV, Swami S, Giovannucci E, Feldman BJ. The role of vitamin D in reducing cancer risk and progression. Nat Rev Cancer 2014;14:342-57.
Albertson DG, Ylstra B, Segraves R, Collins C, Dairkee SH, Kowbel D, et al. Quantitative mapping of amplicon structure by array CGH identifies CYP24 as a candidate oncogene. Nat Genet 2000;25:144-6.
Dorjgochoo T, Shi J, Gao YT, Long J, Delahanty R, Xiang YB, et al. Genetic variants in vitamin D metabolism-related genes and body mass index: analysis of genome-wide scan data of approximately 7000 Chinese women. Int J Obes 2012;36:1252-5.
Reimers LL, Crew KD, Bradshaw PT, Santella RM, Steck SE, Sirosh I. Vitamin D-related gene polymorphisms, plasma 25-hydroxyvitamin D, and breast cancer risk. Cancer Causes Control 2015;26:187-203.
Nemenqani DM, Karam RA, Amer MG, Abd El Rahman TM. Vitamin D receptor gene polymorphisms and steroid receptor status among Saudi women with breast cancer. Gene 2015;558:215-9.
McKay JD, McCullough ML, Ziegler RG, Kraft P, Saltzman BS, Riboli E, et al. Vitamin D receptor polymorphisms and breast cancer risk: results from the National Cancer Institute Breast and Prostate Cancer Cohort Consortium. Cancer Epidemiol Biomarkers Prev 2009;18:297-305.
Rollison DE, Cole AL, Tung KH, Slattery ML, Baumgartner KB, Byers T, et al. Vitamin D intake, vitamin D receptor polymorphisms, and breast cancer risk among women living in the southwestern U.S. Breast Cancer Res Treat 2012;132:683-91.
Fuhrman BJ, Freedman DM, Bhatti P, Doody MM, Fu YP, Chang SC, et al. Sunlight, polymorphisms of vitamin D-related genes and risk of breast cancer. Anticancer Res 2013;33:543-52.
Mishra DK, Wu Y, Sarkissyan M, Sarkissyan S, Chen Z, Shang X, et al. Vitamin D receptor gene polymorphisms and prognosis of breast cancer among African-American and Hispanic Women. PLoS One 2013;8:e57967.
Shahbazi S, Alavi S, Majidzadeh-A K, Ghaffarpour M, Soleimani A, Mahdian R. BsmI but not FokI polymorphism of VDR gene is contributed in breast cancer. Med Oncol 2013;30:393-9.
Lu D, Jing L, Zhang S. Vitamin D Receptor Polymorphism and Breast Cancer Risk: A Meta-Analysis. Medicine (Baltimore) 2016;95:e3535.
Huang QQ, Liao YY, Ye XH, Fu JJ, Chen SD. Between VDR polymorphisms and breast cancer: an updated and comparative meta-analysis of crude and adjusted odd ratios. Asian Pac J Cancer Prev 2014;15:847-53.
Xu J, Li H, Gu L, Zhou X. Association between vitamin D receptor poly(A) polymorphism and breast cancer risk: a meta-analysis. Tumour Biol 2014;35: 589-93.
Clendenen TV, Ge W, Koenig KL, Axelsson T, Liu M, Afanasyeva Y, et al. Genetic Polymorphisms in Vitamin D Metabolism and Signaling Genes and Risk of Breast Cancer: A Nested Case-Control Study. PLoS One 2015;10:e0140478.
Lopes N, Sousa B, Martins D, Gomes M, Vieira D, Veronese LA, et al. Alterations in Vitamin D signalling and metabolic pathways in breast cancer progression: a study of VDR, CYP27B1 and CYP24A1 expression in benign and malignant breast lesions. BMC Cancer 2010;10:483-92.
Al-Azhri J, Zhang Y, Bshara W, Zirpoli G, McCann SE, Khoury T, et al. Tumor Expression of Vitamin D Receptor and Breast Cancer Histopathological Characteristics and Prognosis. Clin Cancer Res 2017; 23:97-103.
Kemmis CM, Welsh J. Mammary epithelial cell transformation is associated with deregulation of the vitamin D pathway. J Cell Biochem 2008;105:980-88.
Buras RR, Schumaker LM, Davoodi F, Brenner RV, Shabahang M, Nauta RJ, et al. Vitamin D receptors in breast cancer cells. Breast Cancer Res. Treat 1994;31:191-202.
Byrne I, Flanagan L, Tenniswood M, Welsh JE. Identification of a hormone responsive promoter immediately upstream of exon1c in the human vitamin D receptor gene. Endocrinology 2000;141:2829-36.
Townsend K, Banwell CM, Guy M, Colston KW, Mansi JL, Stewart P, et al. Autocrine metabolism of vitamin D in normal and malignant breast tissue. Clin Cancer Res 2005;11:3679-86.
Osanai M, Lee GH. CYP24A1-induced vitamin D insufficiency promotes breast cancer growth. Oncol Rep 2016;36:2755-62.
Zhalehjoo N, Shakiba Y, Panjehpour M. Gene expression profiles of CYP24A1 and CYP27B1 in malignant and normal breast tissues. Mol Med Rep 2017;15:467-73.
Sheng L, Anderson PH, Turner AG, Pishas KI, Dhatrak DJ, Gill PG, et al. Identificationof vitamin D3 target genes in human breast cancer tissue. J Steroid Biochem Mol Biol 2016;164:90-7.
Robien K, Cutler GJ, Lazovich D. Vitamin D intake and breast cancer risk in postmenopausal women: the Iowa Women's Health Study. Cancer Causes Control 2007;18:775-82.
Cadeau C, Fournier A, Mesrine S, Clavel-Chapelon F, Fagherazzi G, Boutron-Ruault MC. Interaction between current vitamin D supplementation and menopausal hormone therapy use on breast cancer risk: evidence from the E3N cohort. Am J Clin Nutr 2015;102:966-73.
Abbas S, Linseisen J, Rohrmann S, Chang-Claude J, Peeters PH, Engel P, et al. Dietary intake of vitamin D and calcium and breast cancer risk in the European Prospective Investigation into Cancer and Nutrition. Nutr Cancer 2013;65:178-87.
Redaniel MT, Gardner MP, Martin RM, Jeffreys M. The association of vitamin D supplementation with the risk of cancer in postmenopausal women. Cancer Causes Control 2014;25:267-71.
Downloads
Published
Issue
Section
License
บทความทีตีพิมพ์ในวารสารโรคมะเร็งนี้ถือว่าเป็นลิขสิทธิ์ของมูลนิธิสถาบันมะเร็งแห่งชาติ และผลงานวิชาการหรือวิจัยของคณะผู้เขียน ไม่ใช่ความคิดเห็นของบรรณาธิการหรือผู้จัดทํา
