The Comparative Effects of Three Mouthwash Formulas at Nan Provincial Hospital on Oral Mucositis among Cancer Patients Undergoing Chemotherapy
Keywords:
oral mucositis, mouthwash solution, cancer patient, chemotherapyAbstract
This experimental study aimed to compare the protective effect of three mouthwash formulas-- saline solution, baking powder solution, and saline-baking powder solution--on the oral mucositis status of cancer patients undergoing chemotherapy. A total of eighty-eight patients who presented at the Chemotherapy Unit, Nan provincial hospital, between December 1, 2015 and November 30, 2016, were randomly double-blind assigned to use the different mouthwash formulas after each chemotherapy session. The mouthwash regimen lasted 14 days, with a 7-day wash-out period. The participants used three mouthwash formulas. Each mouthwash formula was used 88 times, for a total of 264 administrations. Oral mucositis occurred 85 times in total: in the group using saline solution, 37 times (42.05%); baking powder solution, 30 times (34.09%), and saline-baking powder solution, 18 times (20.45%). The risks of oral mucositis among the three groups were compared; no difference was found between the saline solution and baking powder solution (odds ratio=0.60, P=0.145). However, the saline-baking powder mixture showed significantly lower risk (odds ratio=0.21, P<0.001). There was no difference in severity grade, progression time, or time to recover from inflammation, among the oral mucositis patients after using any of the three mouthwash formulas.
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