8-Hydroxy-2’-deoxyguanosine (8-OHdG) and Cancer
Keywords:
8-OHdG, damage DNA, cancerAbstract
Cancer is the most significant public-health problem in Thailand, with consistently high mortality rates since AD 2000. Therefore, screening and diagnosis of early-stage cancer is needed to reduce mortality and increase survival rates among cancer patients. Recently, several studies have reported 8-OHdG as a biomarker for the diagnosis and early detection of certain cancers, including breast, colorectal, hepatocellular, gastric, lung, cervical, head & neck, and prostate cancer, as detailed in this review article. However, the mechanism of 8-OHdG expression remains unknown. The discovery of biological markers for early screening and diagnosis should provide new options for the screening and diagnosis of early cancer
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