Relationship between Breast Cancer and Vitamin Supplement Use in Premenopausal Women
Keywords:
vitamin supplements, premenopausal women, breast cancer, case-control studyAbstract
Hematological toxicity related to bone marrow suppression is a common treatment complication of patients undergoing chemotherapy. This may cause dose adjustment, delay treatment, or hospitalization, leading to diminished treatment efficacy, clinical status and quality of life. The objective of this descriptive retrospective study was to examine the incidence and severity of hematologic toxicity among breast-cancer patients undergoing chemotherapy. Two hundred and twenty (220) patients underwent chemotherapy at the Chemotherapy Unit, Phrae Hospital, between January 2012 and December 2016. Data collected from patients' records were reviewed for hematological toxicity, comprising anemia, leukopenia, neutropenia, and thrombocytopenia. The incidence and severity of hematological toxicity were analyzed. The findings showed that the highest incidence of anemia was observed in 100% of patients treated with docetaxel and paclitaxel protocols, with leukopenia and neutropenia of 100% and 64.71%, respectively, among patients treated with the paclitaxel protocol. The lowest incidence of thrombocytopenia was found in 11.76% of cases treated with the paclitaxel protocol. The severity of hematological toxicity varied significantly across chemotherapy regimens; the highest severity of anemia (grade 3) was observed among patients treated with the fluorouracil, doxorubicin (Adriamycin), and cyclophosphamide (FAC) and AC protocols, with grade 3 leukopenia in FAC and paclitaxel protocols; both grade 4 neutropenia and grade 3 thrombocytopenia were observed among patients treated with the FAC protocol. It is suggested that hematologic-toxicity complications should be examined regularly and cautiously for breast-cancer patients undergoing chemotherapy
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