The Effect of an automated Chemotherapy drug compounding machine on dissolution time and quality of life among healthcare workers, Bhumibol Adulyadej Hospital
Keywords:
Automated Chemotherapy drug compounding machine, Chemotherapy drug, Dissolution time, Quality of lifeAbstract
This quasi-experimental research aimed to compare the dissolution time of chemotherapy drug between the use of an automated chemotherapy drug compounding machine and manual shaking, and to examine the quality of life among healthcare workers following its implementation. The sample consisted of 20 healthcare workers. The research instruments included: 1) a demographic data form, 2) a record form for the dissolution time of Cyclophosphamide, and 3) a quality-of-life questionnaire using the Thai version of the World Health Organization Quality of Life instrument (WHOQOL–BREF–THAI). Data were analyzed using descriptive statistics, Wilcoxon signed-rank test, Mann–Whitney U test and paired t-tests.
The results showed that the dissolution time of chemothcvapy drugs using the automated chemotherapy drug compounding machine was significantly shorter than that of manual shaking (z = 11.807, p < .001). Additionally, after the implementation of the automated machine, the quality of life of the healthcare workers significantly improved compared to the pre-intervention period (t = -6.34, p < .001). Improvements were observed across all domains of quality of life, with the greatest increase in the environmental domain, followed by physical health, psychological well-being, and social relationships. In conclusion, the automated chemotherapy drug compounding machine enhances the efficiency of chemotherapy preparation by reducing drug dissolution time and improving the quality of life of healthcare workers.
Downloads
References
Rojanamatin J, Ukranun W, Supaattagorn P, Chiawiriyabunya I, Wongsena M, Chaiwerawattana A, et al. Cancer in Thailand vol. X, 2016–2018. Bangkok: National Cancer Institute; 2021. (in Thai)
National Cancer Institute. Cancer anywhere. Journal of The Department of Medical Services. 2022;47(4):5-9. (in Thai)
Ministry of Public Health. Public health statistics A.D. 2023. Nonthaburi: Division of Strategy and Planning; 2023. (in Thai)
Anand U, Dey A, Chandel AKS, Sanyal R, Mishra A, Pandey DK, et al. Cancer chemotherapy and beyond: current status, drug candidates, associated risks and progress in targeted therapeutics. Genes & diseases. 2022;10(4): 1367–401.
Zhang XH, Hao S, Gao B, Tian WG, Jiang Y, Zhang S, et al. A network meta-analysis for toxicity of eight chemotherapy regimens in the treatment of metastatic/advanced breast cancer. Oncotarget. 2016;7(51):84533-43.
Ndaw S, & Remy A. Occupational exposure to antineoplastic drugs in twelve French health care settings: biological monitoring and surface contamination. International journal of environmental research and public health. 2023;20(6):4952.
Villa A, Molimard M, Sakr D, Lassalle R, Bignon E, Martinez B, et al. Nurses’ internal contamination by antineoplastic drugs in hospital centers: a cross-sectional descriptive study. International archives of occupational and environmental health. 2021;94(8):1839–50.
Batson S, Mitchell SA, Lau D, Canobbio M, de Goede A, Singh I, et al. Automated compounding technology and workflow solutions for the preparation of chemotherapy: a systematic review. European journal of hospital pharmacy. 2020;27(6):330–6.
Baxter Healthcare (Thailand) Co., Ltd. Endoxan (cyclophosphamide): package insert. 2016. (in Thai)
Abu-Alhaija MA, Al-Khawaldeh OA, & Al Bashtawy M. Factors influencing occupational exposure to chemotherapy among oncology nurses. Journal of Oncology Pharmacy Practice. 2023;29(5):1–10.
Reis TR, Silva AB, & Oliveira MC. Health effects of ergonomics and personal protective equipment in chemotherapy handling. Current oncology. 2025;32(10):563.
Branch RM. Instructional design: the ADDIE approach. New York: Springer; 2009.
WHOQOL Group. The World Health Organization quality of life assessment (WHOQOL): position paper from the World Health Organization. Social science & medicine. 1995;41(10):1403–9.
Mahatnirunkul S, Pongpanich V, & Pattanapong N. WHOQOL-BREF-THAI: Thai version of the World Health Organization quality of life instrument (brief version). Bangkok: Department of Mental Health, Ministry of Public Health; 2002. (in Thai)
Lakkhanawanakul A, Siripakornkarn T, & Tungkhasamit T. Effectiveness of a chemotherapy preparation robot in terms of accuracy, precision, and preparation time for injectable anticancer drugs in Udonthani Cancer Hospital. Journal of The Department of Medical Services. 2023;48(4):47–54. (in Thai)
Khatatbeh H, Pakai A, Al-Dwaikat T, Onchonga D, Amer F, Prémusz V, et al. Nurses’ burnout and quality of life: a systematic review and critical analysis of measures used. Nursing open. 2022;9(3):1564-74.
Ruiz-Fernández MD, Ramos-Pichardo JD, Ibáñez-Masero O, Cabrera-Troya J, CarmonaRega MI, & Ortega-Galán ÁM. Compassion fatigue, burnout, compassion satisfaction and perceived stress in healthcare professionals: a systematic review. Journal of clinical nursing. 2020;29(21–22):4321–33.
Wongpimon B, & Aumtaanee A. Nursing care for patients receiving chemotherapy: a qualitative study. Journal of The Royal Thai Army Nurses. 2017;18(Suppl):229-38. (in Thai)
Downloads
Published
How to Cite
Issue
Section
License
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
บทความหรือข้อคิดเห็นใดใดที่ปรากฏในวารสารพยาบาลทหารบกเป็นวรรณกรรมของผู้เขียน ซึ่งบรรณาธิการหรือสมาคมพยาบาลทหารบก ไม่จำเป็นต้องเห็นด้วย
บทความที่ได้รับการตีพิมพ์เป็นลิขสิทธิ์ของวารสารพยาบาลทหารบก
The ideas and opinions expressed in the Journal of The Royal Thai Army Nurses are those of the authors and not necessarily those
of the editor or Royal Thai Army Nurses Association.
