The Efficacy of Intravenous Tranexamic Acid (TXA) in Preventing Acute Postpartum Hemorrhage after Elective Cesarean Section; a Randomized Controlled Trial in Phra Nakhon Si Ayutthaya Hospital

Authors

  • Winai Ruka Department of Obstetrics and Gynecology, Phra Nakhon Si Ayutthaya Hospital

Keywords:

Third stage of labor, Acute postpartum hemorrhage, Tranexamic acid

Abstract

Objective: To evaluate the efficacy of intravenous Tranexamic acid (TXA) in prevention acute postpartum hemorrhage in elective cesarean section patients.

Methods: This study included the 60 patients who performed elective cesarean section by a single obstetrician between November 2020 to January 2021. The 30 patients were TXA users and the others were non-TXA users by randomized grouping. Estimated blood loss, hemoconcentration, changed hemoconcentration, additional uterotonic agents or blood transfusion in 24 hours postpartum period (acute phase) were examined.

Results: Both TXA and non-TXA groups were not statistically different in blood loss (454.67 cc vs 467 cc; p = 0.597, hematocrit (35.67% vs 34.7% ;p = 0.300), dropped hematocrit (47.92% vs 52.08 ; p = 0.519). No additional uterotonic agents, blood transfusion and postpartum hemorrhage in both groups.

Conclusion: Tranexamic acid could not prevent acute postpartum hemorrhage in elective cesarean delivery.

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References

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Published

2022-01-26 — Updated on 2022-01-26

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How to Cite

1.
Ruka ว. The Efficacy of Intravenous Tranexamic Acid (TXA) in Preventing Acute Postpartum Hemorrhage after Elective Cesarean Section; a Randomized Controlled Trial in Phra Nakhon Si Ayutthaya Hospital. JPMAT [Internet]. 2022 Jan. 26 [cited 2022 Aug. 13];11(3):628-40. Available from: https://he01.tci-thaijo.org/index.php/JPMAT/article/view/251597

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Original Article