Efficacy and Safety of Guar Gum Powder on Blood Glucose Control in Non-Diabetic Volunteers
Keywords:
Guar gum, Blood glucose levels, Control, Efficacy, SafetyAbstract
Postprandial hyperglycemia (PPG) is commonly observed in individuals at risk of developing diabetes. The utilization of natural compounds, such as guar gum, which exhibit postprandial glucose–lowering effects, represents a promising alternative strategy for improving glycemic control. This double-blind, randomized, controlled clinical trial aimed to evaluate the efficacy and safety of guar gum powder in controlling postprandial blood glucose in non-diabetic volunteers. Participants received either 6 g of guar gum powder or a placebo prior to consuming 50 g of sucrose, followed by blood glucose monitoring for 180 minutes. Additionally, participants consumed their assigned product twice daily for 4 weeks to assess safety, including evaluations of fasting blood glucose, insulin, lipid profiles, liver and kidney function, and adverse events. The results showed that blood glucose levels at 30 minutes post-sucrose ingestion were significantly lower in the guar gum group than in the placebo group (p < 0.05), with overall postprandial glucose responses also significantly improved (p < 0.05). Furthermore, the four-week consumption of guar gum was safe, with no adverse events reported. In conclusion, guar gum demonstrated both efficacy and safety, suggesting it may serve as a viable dietary intervention for individuals with postprandial hyperglycemia.
References
Pippitt K, Li M, Gurgle HE. Diabetes Mellitus: Screening and Diagnosis. Am Fam Physician. 2016;93(2):103-9. PMID: 26926406.
Bonora E, Muggeo M. Postprandial blood glucose as a risk factor for cardiovascular disease in Type II diabetes: the epidemiological evidence. Diabetologia. 2001;44(12):2107-14. https://10.1007/s001250100020.
Rooney MR, Fang M, Ogurtsova K, Ozkan B, Echouffo-Tcheugui JB, Boyko EJ, et al. Global Prevalence of Prediabetes. Diabetes Care. 2023;46(7):1388-94. https://10.2337/dc22-2376.
Aekplakorn W, Tantayotai V, Numsangkul S, Sripho W, Tatsato N, Burapasiriwat T, et al. Detecting Prediabetes and Diabetes: Agreement between Fasting Plasma Glucose and Oral Glucose Tolerance Test in Thai Adults. J Diabetes Res. 2015;2015:396505. https://10.1155/2015/396505.
Hiyoshi T, Fujiwara M, Yao Z. Postprandial hyperglycemia and postprandial hypertriglyceridemia in type 2 diabetes. J Biomed Res. 2017;33(1):1-16. https://10.7555/jbr.31.20160164.
Chiasson JL, Josse RG, Gomis R, Hanefeld M, Karasik A, Laakso M. Acarbose for prevention of type 2 diabetes mellitus: the STOP-NIDDM randomised trial. Lancet. 2002;359(9323):2072-7. https://10.1016/s0140-6736(02)08905-5.
Hollander P. Safety profile of acarbose, an alpha-glucosidase inhibitor. Drugs. 1992;44 Suppl 3:47-53. https://10.2165/00003495-199200443-00007.
Tahmouzi S, Meftahizadeh H, Eyshi S, Mahmoudzadeh A, Alizadeh B, Mollakhalili-Meybodi N, et al. Application of guar (Cyamopsis tetragonoloba L.) gum in food technologies: A review of properties and mechanisms of action. Food Sci Nutr. 2023;11(9):4869-97. https://10.1002/fsn3.3383.
Yasukawa Z, Inoue R, Ozeki M, Okubo T, Takagi T, Honda A, et al. Effect of Repeated Consumption of Partially Hydrolyzed Guar Gum on Fecal Characteristics and Gut Microbiota: A Randomized, Double-Blind, Placebo-Controlled, and Parallel-Group Clinical Trial. Nutrients. 2019;11(9):2170. https://10.3390/nu11092170.
Okubo T, Ishihara N, Takahashi H, Fujisawa T, Kim M, Yamamoto T, et al. Effects of Partially Hydrolyzed Guar Gum Intake on Human Intestinal Microflora and Its Metabolism. Biosci Biotechnol Biochem. 1994;58(8):1364-9. https://10.1271/bbb.58.1364.
Kapoor MP, Sugita M, Fukuzawa Y, Okubo T. Impact of partially hydrolyzed guar gum (PHGG) on constipation prevention: A systematic review and meta-analysis. J Funct Foods. 2017;33:52-66. https://doi.org/10.1016/j.jff.2017.03.028.
Homann HH, Kemen M, Fuessenich C, Senkal M, Zumtobel V. Reduction in diarrhea incidence by soluble fiber in patients receiving total or supplemental enteral nutrition. JPEN J Parenter Enteral Nutr. 1994;18(6):486-90. https://10.1177/0148607194018006486.
Blackburn NA, Holgate AM, Read NW. Does guar gum improve post-prandial hyperglycaemia in humans by reducing small intestinal contact area? Br J Nutr. 1984;52(2):197-204. https://10.1079/bjn19840088.
Torsdottir I, Alpsten M, Andersson H, Einarsson S. Dietary Guar Gum Effects on Postprandial Blood Glucose, Insulin and Hydroxyproline in Humans. J Nutr. 1989;119(12):1925-31. https://doi.org/10.1093/jn/119.12.1925.
Todd PA, Benfield P, Goa KL. Guar gum. A review of its pharmacological properties, and use as a dietary adjunct in hypercholesterolaemia. Drugs. 1990;39(6):917-28. https://10.2165/00003495-199039060-00007.
McRorie JW, Jr. Evidence-Based Approach to Fiber Supplements and Clinically Meaningful Health Benefits, Part 1: What to Look for and How to Recommend an Effective Fiber Therapy. Nutr Today. 2015;50(2):82-9. https://10.1097/nt.0000000000000082.
Sierra M, Garcia JJ, Fernández N, Diez MJ, Calle AP, Sahagún AM. Effects of ispaghula husk and guar gum on postprandial glucose and insulin concentrations in healthy subjects. Eur J Clin Nutr. 2001;55(4):235-43. https://10.1038/sj.ejcn.1601147.
Asai A, Nakagawa K, Higuchi O, Kimura T, Kojima Y, Kariya J, et al. Effect of mulberry leaf extract with enriched 1-deoxynojirimycin content on postprandial glycemic control in subjects with impaired glucose metabolism. J Diabetes Investig. 2011;2(4):318-23. https://10.1111/j.2040-1124.2011.00101.x.
Kapoor MP, Ishihara N, Okubo T. Soluble dietary fibre partially hydrolysed guar gum markedly impacts on postprandial hyperglycaemia, hyperlipidaemia and incretins metabolic hormones over time in healthy and glucose intolerant subjects. J Funct Foods. 2016;24:207-20. https://doi.org/10.1016/j.jff.2016.04.008.
Kimura T, Nakagawa K, Kubota H, Kojima Y, Goto Y, Yamagishi K, et al. Food-grade mulberry powder enriched with 1-deoxynojirimycin suppresses the elevation of postprandial blood glucose in humans. J Agric Food Chem. 2007;55(14):5869-74. https://10.1021/jf062680g.
Beejmohun V, Peytavy-Izard M, Mignon C, Muscente-Paque D, Deplanque X, Ripoll C, et al. Acute effect of Ceylon cinnamon extract on postprandial glycemia: alpha-amylase inhibition, starch tolerance test in rats, and randomized crossover clinical trial in healthy volunteers. BMC Complement Altern Med. 2014;14:351. https://10.1186/1472-6882-14-351.
Wolever TM, Jenkins DJ, Jenkins AL, Josse RG. The glycemic index: methodology and clinical implications. Am J Clin Nutr. 1991;54(5):846-54. https://doi.org/10.1093/ajcn/54.5.846.
Gerich J. Pathogenesis and management of postprandial hyperglycemia: role of incretin-based therapies. Int J Gen Med. 2013;6:877-95. https://10.2147/ijgm.S51665.
Cerf ME. Beta cell dysfunction and insulin resistance. Front Endocrinol (Lausanne). 2013;4:37. https://10.3389/fendo.2013.00037.
Budreviciute A, Damiati S, Sabir DK, Onder K, Schuller-Goetzburg P, Plakys G, et al. Management and Prevention Strategies for Non-communicable Diseases (NCDs) and Their Risk Factors. Front Public Health. 2020;8:574111. https://10.3389/fpubh.2020.574111.
Palmer SC, Mavridis D, Nicolucci A, Johnson DW, Tonelli M, Craig JC, et al. Comparison of Clinical Outcomes and Adverse Events Associated With Glucose-Lowering Drugs in Patients With Type 2 Diabetes: A Meta-analysis. Jama. 2016;316(3):313-24. https://10.1001/jama.2016.9400.
Wilkinson MJ, Laffin LJ, Davidson MH. Overcoming toxicity and side-effects of lipid-lowering therapies. Best Pract Res Clin Endocrinol Metab. 2014;28(3):439-52. 10.1016/j.beem.2014.01.006.
Cherta-Murillo A, Zhou K, Tashkova M, Frampton J, Cepas de Oliveira AC, Ho C, et al. Investigating the effects of mycoprotein and guar gum on postprandial glucose in type 2 diabetes: a double-blind randomised controlled trial. Nutr Diabetes. 2025;15(1):23. https://10.1038/s41387-025-00375-w.
Javad Alaeian M, Pourreza S, Yousefi M, Golalipour E, Setayesh L, Zeinali Khosroshahi M, et al. The effects of guar gum supplementation on glycemic control, body mass and blood pressure in adults: A GRADE-assessed systematic review and meta-analysis of randomized clinical trials. Diabetes Res Clin Pract. 2023;199:110604. https://10.1016/j.diabres.2023.110604.
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