Blood-Based Proteome Profiles among Healthy and Obese Men with Carotenoid-Rich Jelly Consumption
Keywords:obesity, carotenoid, serum proteome, plasma β-carotene, molecular pathways
Proteomics has clarified the link between obesity and the development of cardiovascular diseases, which involves a combination of genetic predisposition and environmental factors. This randomized, placebo-controlled study investigated the effects of carotenoid in carrot jelly on protein profiles and the clinical and biochemical markers of metabolic syndrome in adult men with obesity. Thirty participants were divided into three groups: healthy (n = 10), obese-treatment (n = 10), and obese-placebo (n = 10). Daily consumption of 200 mL carrot jelly for 3 months in the treatment group led to significant decreases in low-density lipoprotein-cholesterol, fasting plasma glucose and plasma malondialdehyde, and a significant increase in plasma β-carotene (p < 0.05). After 3 months of supplementation, protein interactions in the treatment group indicated important pathways involving Wnt regulation and cell surface-receptor signaling pathways for the upregulated proteins, as well as regulation of cytokine production and cell proliferation pathways for the downregulated proteins. The proteomic patterns clarified the molecular mechanisms underlying obesity-induced metabolic disorders and the potential benefits of carotenoid consumption. Such studies may critically improve serious nutrition-related health issues.
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