Increased Serum Selenium Levels and Metabolic Factors are Associated with Alterations in Biomarkers of Glucose Metabolism
Keywords:
T2DM, Serum selenium, HbA1cAbstract
Selenium is one of the trace elements that has been reported in the pathogenesis of T2DM through oxidative stress and inflammatory pathways. Therefore, the objectives of the present study were to determine serum selenium levels and other factors affecting this levels and to analyze the association between serum selenium levels, fasting blood glucose, HbA1c and risk factors related to T2DM development. Total participants of 890 cases (aged 50-75 years) from the EGAT cohort study conducted in 2013 were analyzed with general characteristic and biochemical data. Serum selenium was measured by ICP-MS. The results showed no significant effects of smoking cigarette, alcohol consumption and dietary pattern on serum selenium levels. Statistical analysis by three groups of subjects with criteria of T2DM by HbA1c level was performed, as normal HbA1c group (HbA1c <5.7% with subgroups of without and with metabolic components) and T2DM risk group (HbA1c ≥5.7%). The means of serum selenium levels in normal HbA1c group, without and with metabolic components (124.3±14.3 µg/L and 129.1±17.6 µg/L, respectively) were lower than those in risk group (132.2±17.1 µg/L). There were significant differences among all three groups in mean levels of clinical and biochemical variables, including SBP, DBP, triglyceride total cholesterol and LDL-cholesterol. Moreover, subjects in the third serum selenium quartile had an increased risk of T2DM (increased levels of FBG and HbA1c) compared with those in the first quartile. In summary, dietary selenium supplements may lead to increased selenium status with potential risks to T2DM together with underlying molecular mechanisms should be further studied.
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