Increased Serum Selenium Levels and Metabolic Factors are Associated with Alterations in Biomarkers of Glucose Metabolism


  • Tatchaporn Manatkitsamran Master of Science Program in Nutrition, Faculty of Medicine Ramathibodi Hospital and Institute of Nutrition
  • Prapimporn Chattranukulchai Department of Medicine, Faculty of Medicine Ramathibodi Hospital, Mahidol University
  • Rodjana Chunhabundit Graduate Program in Nutrition, Faculty of Medicine Ramathibodi Hospital, Mahidol University
  • Pachara Panpunuan Department of Medicine, Faculty of Medicine Ramathibodi Hospital, Mahidol University
  • Dujrudee Matchariyakul Health Office, Electricity Generating Authority of Thailand
  • Piyamitr Sritara Department of Medicine, Faculty of Medicine Ramathibodi Hospital, Mahidol University
  • ๋Jintana Sirivarasai Graduate Program in Nutrition, Faculty of Medicine Ramathibodi Hospital, Mahidol University


T2DM, Serum selenium, HbA1c


Selenium is one of the trace elements that has been reported in the pathogenesis of T2DM through oxidative stress and inflammatory pathways. Therefore, the objectives of the present study were to determine serum selenium levels and other factors affecting this levels and to analyze the association between serum selenium levels, fasting blood glucose, HbA1c and risk factors related to T2DM development. Total participants of 890 cases (aged 50-75 years) from the EGAT cohort study conducted in 2013 were analyzed with general characteristic and biochemical data. Serum selenium was measured by ICP-MS. The results showed no significant effects of smoking cigarette, alcohol consumption and dietary pattern on serum selenium levels. Statistical analysis by three groups of subjects with criteria of T2DM by HbA1c level was performed, as normal HbA1c group (HbA1c   <5.7% with subgroups of without and with metabolic components) and T2DM risk group (HbA1c ≥5.7%).  The means of serum selenium levels in normal HbA1c group, without and with metabolic components (124.3±14.3 µg/L and 129.1±17.6 µg/L, respectively) were lower than those in risk group (132.2±17.1 µg/L). There were significant differences among all three groups in mean levels of clinical and biochemical variables, including SBP, DBP, triglyceride total cholesterol and LDL-cholesterol. Moreover, subjects in the third serum selenium quartile had an increased risk of T2DM (increased levels of FBG and HbA1c) compared with those in the first quartile. In summary, dietary selenium supplements may lead to increased selenium status with potential risks to T2DM together with underlying molecular mechanisms should be further studied.


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1. Zhang H, Yan C, Yang Z, Zhang W, Niu Y, Li X, et al. Alterations of serum trace elements in patients with type 2 diabetes. Journal of Trace Elements in Medicine and Biology. 2017; 40: 91-6.

2. Kieliszek MandBłażejak S. Current Knowledge on the Importance of Selenium in Food for Living Organisms: A Review. Molecules. 2016; 21(5): 609.

3. Thomson C. Assessment of requirements for selenium and adequacy of selenium status: a review. European journal of clinical nutrition. 2004; 58(3): 391-402.

4. Zhou J, Huang KandLei XG. Selenium and diabetes - evidence from animal studies. Free radical biology & medicine. 2013;65:10.1016/j.freeradbiomed.2013.07.012.

5. Wei J, Zeng C, Gong QY, Yang HB, Li XX, Lei GH, et al. The association between dietary selenium intake and diabetes: a cross-sectional study among middle-aged and older adults. Nutr J. 2015; 14: 18.

6. Wang X-l, Yang T-b, Wei J, Lei G-handZeng C. Association between serum selenium level and type 2 diabetes mellitus: a non-linear dose–response meta-analysis of observational studies. Nutrition Journal. 2016;15(1): 48.

7. Bleys J, Navas-Acien AandGuallar E. Serum selenium and diabetes in U.S. adults. Diabetes Care. 2007; 30(4): 829-34.

8. Laclaustra M, Navas-Acien A, Stranges S, Ordovas JMandGuallar E. Serum selenium concentrations and diabetes in U.S. adults: National Health and Nutrition Examination Survey (NHANES) 2003-2004. Environ Health Perspect. 2009; 117(9): 1409-13.

9. Stranges S, Galletti F, Farinaro E, D'Elia L, Russo O, Iacone R, et al. Associations of selenium status with cardiometabolic risk factors: an 8-year follow-up analysis of the Olivetti Heart study. Atherosclerosis. 2011; 217(1):274-8.

10. Flores CR, Puga MP, Wrobel K, Garay Sevilla MEandWrobel K. Trace elements status in diabetes mellitus type 2: possible role of the interaction between molybdenum and copper in the progress of typical complications. Diabetes Res Clin Pract. 2011; 91(3): 333-41.

11. Kornhauser C, Garcia-Ramirez JR, Wrobel K, Pérez-Luque E-L, Garay-Sevilla MEandWrobel K. Serum selenium and glutathione peroxidase concentrations in type 2 diabetes mellitus patients. Primary Care Diabetes. 2008; 2(2): 81-5.

12. Whiting PH, Kalansooriya A, Holbrook I, Haddad FandJennings PE. The relationship between chronic glycaemic control and oxidative stress in type 2 diabetes mellitus. Br J Biomed Sci. 2008; 65(2): 71-4.

13. Zhao C, Wang H, Zhang JandFeng L. [Correlations of trace elements, glucose and body compositions in type 2 diabetics]. Wei Sheng Yan Jiu. 2008; 37(5): 600-1, 5.

14. Thomas B, Ramesh A, Suresh SandPrasad BR. A comparative evaluation of antioxidant enzymes and selenium in the serum of periodontitis patients with diabetes mellitus type 2. Contemp Clin Dent. 2013; 4(2): 176-80.

15. ADA. Standards of Medical Care in Diabetesd. Diabetes Care. CLINICAL AND APPLIED RESEARCH AND EDUCATION. 2016; 39(supplement),: S14-S6.

16. Singh PP, Mahadi F, Roy AandSharma P. Reactive oxygen species, reactive nitrogen species and antioxidants in etiopathogenesis of diabetes mellitus type-2. Indian journal of clinical biochemistry: IJCB. 2009; 24(4): 324-42.

17. Stapleton SR. Selenium: an insulin-mimetic. Cell Mol Life Sci. 2000; 57(13-14): 1874-9.

18. Wang XD, Vatamaniuk MZ, Wang SK, Roneker CA, Simmons RAandLei XG. Molecular mechanisms for hyperinsulinae mia induced by overproduction of selenium-dependent glutathione peroxida se-1 in mice. Diabetologia. 2008; 51(8): 1515-24.

19. Ogawa-Wong AN, Berry MJandSeale LA. Selenium and Metabolic Disorders: An Emphasis on Type 2 Diabetes Risk. Nutrients. 2016; 8(2): 80.

20. Wang X, Zhang W, Chen H, Liao N, Wang Z, Zhang X, et al. High selenium impairs hepatic insulin sensitivity through opposite regulation of ROS. Toxicol Lett. 2014; 224(1): 16-23.

21. Singhatas P SA, Sumritpradit P, Thampongsa T, Krutsri C, Lertsithichai P. Prospective Cohort Study of Serum Selenium in Surgical ICU Patients. J Med Assoc Thai. 2017; 100: 59.

22. Letsiou S, Nomikos T, Panagiotakos D, Pergantis SA, Fragopoulou E, Antonopoulou S, et al. Serum total selenium status in Greek adults and its relation to age. The ATTICA study cohort. Biol Trace Elem Res. 2009; 128(1): 8-17.

23. Luty-Frackiewicz A, Jethon ZandJanuszew ska L. Effect of smoking and alcohol consumption on the serum selenium level of Lower Silesian population. Sci Total Environ. 2002; 285(1-3): 89-95.

24. Chiba MandMasironi R. Toxic and trace elements in tobacco and tobacco smoke. Bull World Health Organ. 1992; 70(2): 269-75.

25. Rossi G. [Diagnosis and classification of diabetes mellitus]. Recenti Prog Med. 2010; 101(7-8): 274-6.

26. Aekplakorn W, Chariyalertsak S, Kessomboon P, Sangthong R, Inthawong R, Putwatana P, et al. Prevalence and management of diabetes and metabolic risk factors in Thai adults: the Thai National Health Examination Survey IV, 2009. Diabetes Care. 2011; 34(9): 1980-5.

27. Aekplakorn W, Chariyalertsak S, Kessom boon P, Assanangkornchai S, Taneepa nichskul SandPutwatana P. Prevalence of Diabetes and Relationship with Socioeconomic Status in the Thai Population: National Health Examination Survey, 2004-2014. J Diabetes Res. 2018; 2018: 1654530.

28. Wan Nazaimoon WM, Md Isa SH, Wan Mohamad WB, Khir AS, Kamaruddin NA, Kamarul IM, et al. Prevalence of diabetes in Malaysia and usefulness of HbA1c as a diagnostic criterion. Diabet Med. 2013; 30(7): 825-8.

29. Disease Burden. Diabetes Prevalence in Singapore. Singapore Ministry of Health,” 2015, 2015 [updated 7 Aug 2016. Available from: content/moh_web /home/statistics/Health_ Facts_Singapore/Disease_Burden.htm




How to Cite

Manatkitsamran, T., Chattranukulchai, P., Chunhabundit, R., Panpunuan, P., Matchariyakul, D., Sritara, P., & Sirivarasai ๋. (2019). Increased Serum Selenium Levels and Metabolic Factors are Associated with Alterations in Biomarkers of Glucose Metabolism. Journal of Nutrition Association of Thailand, 54(1), 69–84. Retrieved from



Research article