Water extract from leaf and stem of White Mugwort inhibits enzyme activity of α-amylase and α-glucosidase


  • สุดาทิพย์ แซ่ตั้น Department of Food Science and Technology, Faculty of Agro-Industry, Kasetsart University
  • ประภาพร คุณปัญญา Department of Food Science and Technology, Faculty of Agro-Industry, Kasetsart University


Type 2 Diabetes, White Mugwort (Artemisia lactiflora), Alpha-amylase


Type 2 diabetes (T2D) is the condition that a person has high blood glucose. This condition results from insulin insensitivity or the lack of insulin. T2D is one of global public health problems including Thailand. So far, many studies have reported anti-diabetic activities of various plant extracts. This research focused on the inhibitory potential of aqueous extract from leaf and stem of White Mugwort (Artemisia lactiflora) on digestive enzymes related to type 2 diabetes. The study found that total phenolic content of aqueous White Mugwort extract was 1.25 mggallic acid equivalent/g dry weight. The aqueous White Mugwort extract also shows the inhibitory effect ona-amylase with IC50 = 44.2 mg/mL, anda-glucosidase with IC50 = 1.3 mg/mL. This is the first time that the inhibitory effect of White Mugwort against carbohydrate-metabolizing enzymes is reported. Overall, our findings suggest that regular consumption of White Mugwort may slow release of simple sugars in the gut and thereby decrease postprandial hyperglycemia.


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How to Cite

แซ่ตั้น ส., & คุณปัญญา ป. (2017). Water extract from leaf and stem of White Mugwort inhibits enzyme activity of α-amylase and α-glucosidase. Journal of Nutrition Association of Thailand, 52(2), 16–22. Retrieved from https://he01.tci-thaijo.org/index.php/JNAT/article/view/116100



Research article