Clinical outcomes of cancer treatment in the elderly with comorbidities: A systematic review
Article Sidebar
Main Article Content
Abstract
The number of comorbidities in cancer patients has increased recently. The increasing proportion of older patients with comorbidities may impact the diagnosis, treatment, and outcomes of cancer patients. Although there is consensus on how to capture, interpret, or manage comorbidities in the context of cancer patients, clinical outcomes have been found to be less likely to be treated with intent. The purpose of this systematic literature review is to compile research on the clinical outcomes of cancer treatment in older people with comorbidities. Our aim is to summarize the clinical outcomes of cancer treatment in older people with comorbidities between 2012 and 2021 by systematically searching electronic databases. Both national and international research studies were conducted. There were a total of 10 studies that met the inclusion criteria and passed the critical appraisal. The study showed that survival rate, cancer-free period, and the rate of cancer recurrence, a prognostic factor, worsen with increasing comorbidity and age. Therefore, the results of the study highlight the importance of assessing and reviewing comorbidities in older people with cancer. This is a problem-solving technique that involves updating the database for patients with comorbidities. Existing clinical tools tailored to the patient aid in decision making for improved care integration to improve clinical outcomes in older adults with cancer who have comorbidities. The study findings underscore the importance of assessing and reviewing comorbidities in older adults with cancer.
Downloads
Article Details
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
บทความที่ได้รับการตีพิมพ์เป็นลิขสิทธิ์ของวิทยาลัยพยาบาลบรมราชชนนี จังหวัดนนทบุรี
ข้อความที่ปรากฏในบทความแต่ละเรื่องในวารสารวิชาการเล่มนี้เป็นความคิดเห็นส่วนตัวของผู้เขียนแต่ละท่านไม่เกี่ยวข้องกับวิทยาลัยพยาบาลบรมราชชนนี จังหวัดนนทบุรี และคณาจารย์ท่านอื่น ในวิทยาลัยฯ แต่อย่างใด ความรับผิดชอบองค์ประกอบทั้งหมดของบทความแต่ละเรื่องเป็นของผู้เขียนแต่ละท่าน หากมีความผิดพลาดใด ๆ ผู้เขียนแต่ละท่านจะรับผิดชอบบทความของตนเองแต่ผู้เดียว
References
Department of Older Persons, Ministry of Social Development and Human Security. Elderly statistics 2020. [internet]. 2021 [cited 2021 Oct 15]; Available from: https://www.dop.go.th/th/know/side/1/1/967. (in Thai).
Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A, et al. Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2021;71(3):209–49. doi: 10.3322/caac.21660.
Rojanamatin J, Ukranun W, Supaattagorn P, Chiawiriyabunya I, Wongsena M, Chaiwerawattana A, et al. Cancer in Thailand Vol. X, 2016-2018. Bangkok, Thailand; 2021. (in Thai).
Williams GR, Mackenzie A, Magnuson A, et al. Comorbidity in older adults with cancer. J Geriatr Oncol. 2016;7(4):249–57.
doi: 10.1016/j.jgo.2015.12.002.
Wenkstetten-Holub A, Fangmeyer-Binder M, Fasching P. Prevalence of comorbidities in elderly cancer patients. Memo. 2021;14: 15–9. doi: 10.1007/s12254-020-00657-2.
Søgaard M, Thomsen RW, Bossen KS, Sørensen HT, Nørgaard M. The impact of comorbidity on cancer survival: a review. Clin Epidemiol. 2013;5(Suppl 1):3-29. doi: 10.2147/CLEP.S47150.
Sun V, Burhenn PS, Lai L, Hurria A. The impact of comorbidity on surgical outcomes in older adults with cancer. Semin Oncol Nurs. 2017;33(1):80-6. doi: 10.1016/j.soncn.2016.11.008.
Skorus U, Kenig J. Oncogeriatrics (part 5.) The role of comorbidities in older patients with cancer. NOWOTWORY J Oncol. 2020;70 (2):54–9. doi: 10.5603/NJO.2020.0013.
Mallen A, Todd S, Robertson SE, Kim J, Sehovic M, Wenham RM, et al. Impact of age, comorbidity, and treatment characteristics on survival in older women with advanced high-grade epithelial ovarian cancer. Gynecol Oncol. 2021;161 (3):693-9. doi: 10.1016/j.ygyno.2021.03.008.
Fowler H, Belot A, Ellis L, Maringe C, Luque-Fernandez MA, Njagi EN, et al. Comorbidity prevalence among cancer patients: a population-based cohort study of four cancers. BMC Cancer. 2020;20(1):2. doi: 10.1186/s12885-019-6472-9.
The Joanna Briggs Institute. Critical appraisal tools. [internet]. 2017 [cited 2021 Oct 15]; Available from: http://joannabriggs. org/research/critical-appraisal-tools.html.
Page MJ, McKenzie JE, Bossuyt PM, Boutron I, Hoffmann TC, Mulrow CD, et al. The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. BMJ. 2021;372:n71. doi: 10.1136/bmj.n71.
De Boer AZ, Bastiaannet E, Putter H, Marang-van de Mheen PJ, Siesling S, De Munck L, et al. Prediction of other-cause mortality in older patients with breast cancer using comorbidity. Cancers (Basel). 2021;13(7):1627. doi: 10.3390/cancers1 3071627.
Niksic M, Redondo-Sanchez D, Chang YL, Rodriguez-Barranco M, Exposito-Hernandez J, Marcos-Gragera R, et al. The role of multimorbidity in short-term mortality of lung cancer patients in Spain: a population-based cohort study. BMC Cancer. 2021;21(1):1048. doi: 10.1186/s 12885-021-08801-9.
Ghanizada M, Jakobsen KK, Jensen JS, Wessel I, Tvedskov JF, Grønhøj C, et al. The impact of comorbidities on survival in oral cancer patients: a population-based, case-control study. Acta Oncol. 2021;60(2): 173-79. doi: 10.1080/0284186X.2020.18 36393.
Ruud Kjær EK, Jensen JS, Jakobsen KK, Lelkaitis G, Wessel I, von Buchwald C. The impact of comorbidity on survival in patients with head and neck squamous cell carcinoma: A Nationwide case-control study Spanning 35 Years. Front Oncol. 2021;10:617184. doi: 10.3389/fonc.2020. 617184.
Desai R, Camacho F, Tan X, LeBaron V, Blackhall L, Balkrishnan R. Mental health comorbidities and elevated risk of opioid use in elderly breast cancer survivors using adjuvant endocrine treatments. J Oncol Pract. 2019;15(9):e777-86. doi: 10.1200/JOP.18.00781.
Schimansky S, Lang S, Beynon R, Penfold C, Davies A, Waylen A. et al. Association between comorbidity and survival in head and neck cancer: Results from head and neck 5000. Head Neck. 2019;41(4):1053-62. doi: 10.1002/hed.25543.
Derks MGM, van de Velde CJH, Giardiello D, Seynaeve C, Putter H, Nortier JWR, et al. Impact of comorbidities and age on cause-specific mortality in postmenopausal patients with breast cancer. Oncologist. 2019;24(7):e467-74. doi: 10.1634/theoncologist.2018-0010.
Boakye D, Rillmann B, Walter V, Jansen L, Hoffmeister M, Brenner H. Impact of comorbidity and frailty on prognosis in colorectal cancer patients: A systematic review and meta-analysis. Cancer Treat Rev. 2018;64:30-9. doi: 10.1016/j.ctrv. 2018.02.003.
Haller DG, O'Connell MJ, Cartwright TH, Twelves CJ, McKenna EF, Sun W, et al. Impact of age and medical comorbidity on adjuvant treatment outcomes for stage III colon cancer: a pooled analysis of individual patient data from four randomized, controlled trials. Ann Oncol. 2015;26(4):715-24. doi: 10.1093/ annonc/mdv003.
Kiderlen M, De Glas N, Bastiaannet E, Van de Water W, De Craen AJ, Guicherit OR, et al. Impact of comorbidity on outcome of older breast cancer patients: a FOCUS cohort study. Breast Cancer Res Treat. 2014;145(1):185–92. doi: 10. 1007/s10549-014-2917-7.
Charlsona ME, Carrozzinob D, Guidib J, Patierno C. Charlson comorbidity index: A critic review of clinometric properties. Psychother Psychosom 2022;91(1):8–35. doi: 10.1159/000521288.
