เอบีโอแอนติบอดีไตเตอร์ในผู้ที่มีสุขภาพดีหลังการฉีดวัคซีนป้องกันโรคโควิค-19 เข็มที่ 2

Kanjana Sirirat; Sarawut Suttirat; Wachiraya Athimang; Weerawan Charnsilpa; Tanasan Sirirat

Authors

Kanjana Sirirat Faculty of Medical Technology, Huachiew Chalermprakiet University
Sarawut Suttirat Faculty of Medical Technology, Huachiew Chalermprakiet University
Wachiraya Athimang Faculty of Medical Technology, Huachiew Chalermprakiet University
Weerawan Charnsilpa Faculty of Medical Technology, Huachiew Chalermprakiet University
Tanasan Sirirat Faculty of Medical Technology, Huachiew Chalermprakiet University

Keywords:

ABO blood group, ABO antibody titers, COVID-19 vaccines

Abstract

ABO blood group antibodies (ABO antibodies) are of clinical importance which can cause red blood cell lysis in the blood circulation. Environmental factors such as lifestyle changes and vaccination may result in increased ABO antibody production. Therefore, the objective of this study was to investigate anti-A and anti-B titers using saline agglutination and indirect antiglobulin in 110 healthy individuals who received the second dose of COVID-19 vaccination. This descriptive cross-sectional study was analyzed using descriptive statistics. The results showed that blood type O had significantly higher anti-A and anti-B titers of both IgM and IgG types than the other blood types. The prevalence of high titers found that those with high IgM anti-A in the blood types O and B was at 30% and 8.6%, respectively. Those with high IgM anti-B in blood type O and A were 30% and 8%, respectively. No finding in blood type A and B had high IgG titers, but high IgG anti-A and anti-B titers were found in blood type O of 16% and 18%, respectively. In conclusion, the ABO antibody titers among healthy individuals after receiving the second dose of the COVID-19 vaccine mostly displayed low titers. However, those with blood type O were more likely to have high ABO antibody titers. Thus, ABO antibody titers testing should be determined in blood type O, especially, platelet apheresis donors and pregnant women for preventing red blood cell lysis.

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