The Effects of Sulodexide on the Prevention of Peritoneal Membrane Changes in Peritoneal Dialysis Patients

Authors

  • Panida Ditsawanon Faculty of Pharmaceutical Science, Chulalongkorn University
  • อุปถัมภ์ ศุภสินธุ์
  • พรอนงค์ อร่ามวิทย์

Keywords:

Sulodexide, peritoneal dialysis, peritoneal membrane

Abstract

            The objective of this placebo-controlled clinical study was to investigate the effects of sulodexide on the prevention of peritoneal membrane changes in CAPD patients by evaluating peritoneal membrane transports. A total of 66 patients, divided into 33 patients for each group, were included in this randomized control trial study. Patients were randomly assigned to receive either oral sulodexide 100 mg/day or a placebo. A 4-hour peritoneal equilibrium test was performed to evaluate peritoneal transport function. 61 patients completed the 3-month study. After the treatment period, there was a significantly lower D/P creatinine in the sulodexide group than in the placebo group (p-value = 0.04). However, no significant difference in D/D0 glucose was observed between the two groups. For ultrafiltration volume, there was a significantly higher volume in the sulodexide group when compared to the placebo group (p-value = 0.01). Besides, adverse event of sulodexide was not different from the placebo group. In conclusion, the administration of oral sulodexide has a potentially beneficial effect in the prevention of peritoneal membrane damage in PD patients.

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Published

2020-06-29

How to Cite

1.
Ditsawanon P, ศุภสินธุ์ อ, อร่ามวิทย์ พ. The Effects of Sulodexide on the Prevention of Peritoneal Membrane Changes in Peritoneal Dialysis Patients. Journal of Health Sciences and Wellness [Internet]. 2020 Jun. 29 [cited 2024 Dec. 8];24(1):33-41. Available from: https://he01.tci-thaijo.org/index.php/HCUJOURNAL/article/view/209547

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Research article