The Effects of Sulodexide on the Prevention of Peritoneal Membrane Changes in Peritoneal Dialysis Patients
Keywords:
Sulodexide, peritoneal dialysis, peritoneal membraneAbstract
The objective of this placebo-controlled clinical study was to investigate the effects of sulodexide on the prevention of peritoneal membrane changes in CAPD patients by evaluating peritoneal membrane transports. A total of 66 patients, divided into 33 patients for each group, were included in this randomized control trial study. Patients were randomly assigned to receive either oral sulodexide 100 mg/day or a placebo. A 4-hour peritoneal equilibrium test was performed to evaluate peritoneal transport function. 61 patients completed the 3-month study. After the treatment period, there was a significantly lower D/P creatinine in the sulodexide group than in the placebo group (p-value = 0.04). However, no significant difference in D/D0 glucose was observed between the two groups. For ultrafiltration volume, there was a significantly higher volume in the sulodexide group when compared to the placebo group (p-value = 0.01). Besides, adverse event of sulodexide was not different from the placebo group. In conclusion, the administration of oral sulodexide has a potentially beneficial effect in the prevention of peritoneal membrane damage in PD patients.
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