Selected Factors Related to Febrile Neutropenia of Lymphoma Patients Undergoing Chemotherapy

Abstract

Purpose: To examine the occurrence of febrile neutropenia and to study the relationship between Age, Gender, Albumin, Type of lymphoma, Stage of cancer, Number of chemotherapy sessions,  Comorbidities, Self-care Behavior, Physical activity and Febrile neutropenia in lymphoma patients who received chemotherapy.

Design: Descriptive Research

Methods: The study sample consisted of 114 individuals with lymphoma who received services at the Hematology outpatient department, King Chulalongkorn Memorial Hospital. The research tools used included personal data questionnaires, self-care behavior, and physical activity questionnaires. The content validity was checked to be equal to 1.0 and the reliability was checked and Cronbach's alpha coefficients were 0.76 and 0.72, respectively. Data were analyzed using descriptive statistics and logistic regression analysis. Data were analyzed using descriptive statistics and logistic regression analysis.

Results: The research findings revealed that 34.2% of individuals with lymphoma receiving chemotherapy experienced Febrile neutropenia (FN), with the majority occurring during the first round of chemotherapy (48.7%) and febrile neutropenia occurring only once, accounting for 84.6%. Factors associated with the occurrence of febrile neutropenia included being female, age 60 or older, low levels of blood albumin (< 3.5 g/dL), advanced stage of cancer, the number of chemotherapy cycles, and the presence of comorbidities (OR=5.43, 1.68, 4.76, 1.62, 1.83, 2.33 respectively, p<.05). On the other hand, factors associated with a decreased risk of Febrile neutropenia included physical activity (OR= 0.58, p<.05). Factors unrelated to febrile neutropenia included self-care behavior and cancer type (OR=0.62, 1.15 respectively, p>.05).