Factors associated with rapid decline of renal function in patients with kidney disease: a retrospective cohort study
Keywords:rapid decline of renal function, chronic kidney disease, factors
To delay the progression of end stage renal disease, the determination of risk factors of rapid glomerular filtration rate (GFR) decline in the early stage of kidney disease is crucial. The purpose of this retrospective cohort study was to identify factors associated with rapid GFR decline in patients with kidney disease. By using the systematic random sampling, 745 participants were included in the study. They were diagnosed with chronic kidney disease stage 1-3b and received health services at the outpatient department of Chumpae Hospital, Khon Kaen during 2015-2017. Multiple logistic regression was used to analyze the factors. The results showed that factors associated with rapid GFR decline were 1) Body Mass Index (BMI) [BMI<18.5 (ORadj 6.95, 95%CI 1.88-25.77); BMI 23-24.9 (ORadj 1.60, 95%CI 1.01-2.55)]; 2) systolic blood pressure>140 mmHg (ORadj 1.42, 95%CI 1.03-1.95); and 3) chronic kidney disease stage 2 (ORadj 1.50, 95%CI 1.01-2.23). Factors associated with the delay of rapid GFR decline were 1) age [age 41-60 years old (ORadj 0.40, 95%CI 0.17-0.97), age 60 years old and over (ORadj 0.37, 95% CI 0.15-0.89)]; and 2) chronic kidney disease stage 3b (ORadj 0.39, 95%CI 0.19-0.80)
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