ผลของการขาดหรือได้รับทอรีนเสริมในช่วงก่อนและหลังคลอดต่อระดับของ MDA และทอรีนในพลาสมาในหนูเพศเมียวัยโตเต็มที่
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เผยแพร่แล้ว:
ก.ค. 11, 2019
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ภาวะทอรีนช่วงก่อนและหลังคลอด พลาสมาทอรีน พลาสมามาลอนไดอัลดีไฮด์ หนูเพศเมียวัยโตเต็มที่
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บทคัดย่อ
การเสียสมดุลของทอรีนในช่วงก่อนและหลังคลอดเหนี่ยวนำให้ไตสูญเสียหน้าที่ในหนูเพศเมียวัยโตเต็มที่โดยผ่านการทำงานของระบบเรนินร่วมแองจิโอเทนซินที่มากเกินไป การศึกษานี้ทดสอบสมมุติฐานที่ว่าการขาดทอรีนหรือได้รับทอรีนเสริมในช่วงก่อนและหลังคลอดมีผลกระทบต่อระดับ MDA และระดับทอรีนในพลาสมาในหนูเพศเมียวัยโตเต็มที่ หนูเพศเมียพันธุ์ Sprague-Dawley ได้รับอาหารปกติ และน้ำประปาอย่างเดียว (control, CW) หรือน้ำประปาผสมบีตาอะลานินร้อยละ 3 (taurine depletion, TDW) หรือน้ำประปาผสมทอรีนร้อยละ 3 (taurine supplementation, TSW) ตั้งแต่เริ่มตั้งท้องจนกระทั่งลูกหนูหย่านม เมื่ออายุได้ 7-8 สัปดาห์ หนูถูกบันทึกน้ำหนักตัว หัวใจและไต และเก็บเลือด 2 มิลลิลิตรจาก abdominal aorta เพื่อวิเคราะห์ระดับ MDA และทอรีนในพลาสมา ผลการศึกษาพบว่าน้ำหนักตัว หัวใจและไต สัดส่วนของน้ำหนักหัวใจต่อน้ำหนักตัว สัดส่วนของน้ำหนักไตต่อน้ำหนักตัว และระดับ MDA ในพลาสมาไม่มีค่าแตกต่างกันทางสถิติระหว่างหนูทดลองทั้งสามกลุ่ม อย่างไรก็ตามระดับ MDA มีแนวโน้มที่จะสูงในกลุ่ม TDW และกลุ่ม TSW เมื่อเปรียบเทียบกับกลุ่มควบคุม ระดับของทอรีนในพลาสมาในกลุ่ม TDW และกลุ่ม TSW มีค่าต่ำกว่ากลุ่มควบคุมอย่างมีนัยสำคัญทางสถิติ จากข้อมูลชี้ให้เห็นว่าการเสียสมดุลของทอรีนในช่วงก่อนและหลังคลอดอาจมีผลกระทบต่อระดับ MDA และทอรีนในพลาสมาในหนูเพศเมียวัยโตเต็มที่
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Aerts, L., Van Assche, F.A., 2002, Taurine and taurine-deficiency in the perinatal period. Journal of Perinatal Medicine 30, 281-286.
Aversa, S., Pellegrino, S., Barberi, I., Reiter, R.J., Gitto, E., 2012, Potential utility of melatonin as an antioxidant during pregnancy and in the perinatal period. Journal of Maternal-Fetal Neonatal Medicine 25, 207-221.
Barker, D.J., 2002, Fetal programming of coronary heart disease. Trends Endocrinol Metab 13, 364-368.
Cao, S.L., Jiang, H., Niu, S.P., Wang, X.H., Du, S., 2018, Effects of Taurine Supplementation on Growth in Low Birth Weight Infants: A Systematic Review and Meta-Analysis. Indian Journal of Pediatrics.
Cheong, S.H., Moon, S.H., Lee, S.J., Kim, S.H., Chang, K.J., 2013, Antioxidant and DNA protection effects of taurine by electron spin resonance spectroscopy. Advances in Experimental Medicine and Biology 776, 167-177.
Cruz, C.I., Ruiz-Torres, P., del Moral, R.G., Rodriguez-Puyol, M., Rodriguez-Puyol, D., 2000, Age-related progressive renal fibrosis in rats and its prevention with ACE inhibitors and taurine. American Journal of Physiology-Renal Physiology 278, F122-129.
Fujita, T., Sato, Y., Ando, K., 1986, Changes in cardiac and hypothalamic noradrenergic activity with taurine in DOCA-salt rats. American Journal of Physiology 251, H926-933.
Hu, J., Xu, X., Yang, J., Wu, G., Sun, C., Lv, Q., 2009, Antihypertensive effect of taurine in rat. Advances in Experimental Medicine and Biology 643, 75-84.
Huxtable, R.J., 1992, Physiological actions of taurine. Physiological Reviews 72, 101-163.
Ito, T., Schaffer, S., Azuma, J., 2014, The effect of taurine on chronic heart failure: actions of taurine against catecholamine and angiotensin II. Amino Acids 46, 111-119.
Jong, C.J., Azuma, J., Schaffer, S., 2012, Mechanism underlying the antioxidant activity of taurine: prevention of mitochondrial oxidant production. Amino Acids 42, 2223-2232.
Jong, C.J., Azuma, J., Schaffer, S.W., 2011, Role of mitochondrial permeability transition in taurine deficiency-induced apoptosis. Experimental & Clinical Cardiology 16, 125-128.
Jong, C.J., Ito, T., Prentice, H., Wu, J.Y., Schaffer, S.W., 2017, Role of Mitochondria and Endoplasmic Reticulum in Taurine-Deficiency-Mediated Apoptosis. Nutrients 9.
Kim, C., Cha, Y.N., 2009, Production of reactive oxygen and nitrogen species in phagocytes is regulated by taurine chloramine. Advances in Experimental Medicine and Biology 643, 463-472.
Larsen, L.H., Sando-Pedersen, S., Orstrup, L.K.H., Grunnet, N., Quistorff, B., Mortensen, O.H., 2017, Gestational Protein Restriction in Wistar Rats; Effect of Taurine Supplementation on Properties of Newborn Skeletal Muscle. Advances in Experimental Medicine and Biology 975 Pt 1, 413-433.
Lerdweeraphon, W., Wyss, J.M., Boonmars, T., Roysommuti, S., 2015, Perinatal taurine depletion alters the renal excretory effect of the Renin-Angiotensin system in adult female rats. Advances in Experimental Medicine and Biology 803, 679-691.
Lima, L., Obregon, F., Cubillos, S., Fazzino, F., Jaimes, I., 2001, Taurine as a micronutrient in development and regeneration of the central nervous system. Nutritional Neuroscience 4, 439-443.
Macaione, S., Tucci, G., Di Giorgio, R.M., 1975, Taurine distribution in rat tissues during development. Italian Journal of Biochemistry 24, 162-174.
Okamoto, E., Rassin, D.K., Zucker, C.L., Salen, G.S., Heird, W.C., 1984, Role of taurine in feeding the low-birth-weight infant. The Journal of Pediatrics 104, 936-940.
Parildar-Karpuzoglu, H., Mehmetcik, G., Ozdemirler-Erata, G., Dogru-Abbasoglu, S., Kocak-Toker, N., Uysal, M., 2008, Effect of taurine treatment on pro-oxidant-antioxidant balance in livers and brains of old rats. Pharmacological Reports 60, 673-678.
Patrick, L., 2006, Lead toxicity part II: the role of free radical damage and the use of antioxidants in the pathology and treatment of lead toxicity. Alternative Medicine Review 11, 114-127.
Perrone, S., Santacroce, A., Picardi, A., Buonocore, G., 2016, Fetal programming and early identification of newborns at high risk of free radical-mediated diseases. World Journal of Clinical Pediatrics 5, 172-181.
Roysommuti, S., Lerdweeraphon, W., Michael Wyss, J., 2017, Perinatal Taurine Imbalance Followed by High Sugar Intake Alters the Effects of Estrogen on Renal Excretory Function in Adult Female Rats. Advances in Experimental Medicine and Biology 975, 769-787.
Roysommuti, S., Malila, P., Jirakulsomchok, D., Wyss, J.M., 2010, Adult renal function is modified by perinatal taurine status in conscious male rats. Journal of Biomedical Science 17 Suppl 1, S31.
Roysommuti, S., Suwanich, A., Jirakulsomchok, D., Wyss, J.M., 2009a, Perinatal taurine depletion increases susceptibility to adult sugar-induced hypertension in rats. Advances in Experimental Medicine and Biology 643, 123-133.
Roysommuti, S., Suwanich, A., Lerdweeraphon, W., Thaeomor, A., Jirakulsomchok, D., Wyss, J.M., 2009b, Sex dependent effects of perinatal taurine exposure on the arterial pressure control in adult offspring. Advances in Experimental Medicine and Biology 643, 135-144.
Sturman, J.A., 1993, Taurine in development. Physiological Reviews 73, 119-147.
Sturman, J.A., Gargano, A.D., Messing, J.M., Imaki, H., 1986, Feline maternal taurine deficiency: effect on mother and offspring. The Journal of Nutrition 116, 655-667.
Suwanich, A., Wyss, J.M., Roysommuti, S., 2013, Taurine supplementation in spontaneously hypertensive rats: Advantages and limitations for human applications. World Journal of Cardiology 5, 404-409.
Thaeomor, A., Wyss, J.M., Jirakulsomchok, D., Roysommuti, S., 2010, High sugar intake via the renin-angiotensin system blunts the baroreceptor reflex in adult rats that were perinatally depleted of taurine. Journal of Biomedical Science 17 Suppl 1, S30.
Verner, A., Craig, S., McGuire, W., 2007, Effect of taurine supplementation on growth and development in preterm or low birth weight infants. Cochrane Database of Systematic Reviews, CD006072.
Yamori, Y., Liu, L., Mori, M., Sagara, M., Murakami, S., Nara, Y., Mizushima, S., 2009, Taurine as the nutritional factor for the longevity of the Japanese revealed by a world-wide epidemiological survey. Advances in Experimental Medicine and Biology 643, 13-25.
Aversa, S., Pellegrino, S., Barberi, I., Reiter, R.J., Gitto, E., 2012, Potential utility of melatonin as an antioxidant during pregnancy and in the perinatal period. Journal of Maternal-Fetal Neonatal Medicine 25, 207-221.
Barker, D.J., 2002, Fetal programming of coronary heart disease. Trends Endocrinol Metab 13, 364-368.
Cao, S.L., Jiang, H., Niu, S.P., Wang, X.H., Du, S., 2018, Effects of Taurine Supplementation on Growth in Low Birth Weight Infants: A Systematic Review and Meta-Analysis. Indian Journal of Pediatrics.
Cheong, S.H., Moon, S.H., Lee, S.J., Kim, S.H., Chang, K.J., 2013, Antioxidant and DNA protection effects of taurine by electron spin resonance spectroscopy. Advances in Experimental Medicine and Biology 776, 167-177.
Cruz, C.I., Ruiz-Torres, P., del Moral, R.G., Rodriguez-Puyol, M., Rodriguez-Puyol, D., 2000, Age-related progressive renal fibrosis in rats and its prevention with ACE inhibitors and taurine. American Journal of Physiology-Renal Physiology 278, F122-129.
Fujita, T., Sato, Y., Ando, K., 1986, Changes in cardiac and hypothalamic noradrenergic activity with taurine in DOCA-salt rats. American Journal of Physiology 251, H926-933.
Hu, J., Xu, X., Yang, J., Wu, G., Sun, C., Lv, Q., 2009, Antihypertensive effect of taurine in rat. Advances in Experimental Medicine and Biology 643, 75-84.
Huxtable, R.J., 1992, Physiological actions of taurine. Physiological Reviews 72, 101-163.
Ito, T., Schaffer, S., Azuma, J., 2014, The effect of taurine on chronic heart failure: actions of taurine against catecholamine and angiotensin II. Amino Acids 46, 111-119.
Jong, C.J., Azuma, J., Schaffer, S., 2012, Mechanism underlying the antioxidant activity of taurine: prevention of mitochondrial oxidant production. Amino Acids 42, 2223-2232.
Jong, C.J., Azuma, J., Schaffer, S.W., 2011, Role of mitochondrial permeability transition in taurine deficiency-induced apoptosis. Experimental & Clinical Cardiology 16, 125-128.
Jong, C.J., Ito, T., Prentice, H., Wu, J.Y., Schaffer, S.W., 2017, Role of Mitochondria and Endoplasmic Reticulum in Taurine-Deficiency-Mediated Apoptosis. Nutrients 9.
Kim, C., Cha, Y.N., 2009, Production of reactive oxygen and nitrogen species in phagocytes is regulated by taurine chloramine. Advances in Experimental Medicine and Biology 643, 463-472.
Larsen, L.H., Sando-Pedersen, S., Orstrup, L.K.H., Grunnet, N., Quistorff, B., Mortensen, O.H., 2017, Gestational Protein Restriction in Wistar Rats; Effect of Taurine Supplementation on Properties of Newborn Skeletal Muscle. Advances in Experimental Medicine and Biology 975 Pt 1, 413-433.
Lerdweeraphon, W., Wyss, J.M., Boonmars, T., Roysommuti, S., 2015, Perinatal taurine depletion alters the renal excretory effect of the Renin-Angiotensin system in adult female rats. Advances in Experimental Medicine and Biology 803, 679-691.
Lima, L., Obregon, F., Cubillos, S., Fazzino, F., Jaimes, I., 2001, Taurine as a micronutrient in development and regeneration of the central nervous system. Nutritional Neuroscience 4, 439-443.
Macaione, S., Tucci, G., Di Giorgio, R.M., 1975, Taurine distribution in rat tissues during development. Italian Journal of Biochemistry 24, 162-174.
Okamoto, E., Rassin, D.K., Zucker, C.L., Salen, G.S., Heird, W.C., 1984, Role of taurine in feeding the low-birth-weight infant. The Journal of Pediatrics 104, 936-940.
Parildar-Karpuzoglu, H., Mehmetcik, G., Ozdemirler-Erata, G., Dogru-Abbasoglu, S., Kocak-Toker, N., Uysal, M., 2008, Effect of taurine treatment on pro-oxidant-antioxidant balance in livers and brains of old rats. Pharmacological Reports 60, 673-678.
Patrick, L., 2006, Lead toxicity part II: the role of free radical damage and the use of antioxidants in the pathology and treatment of lead toxicity. Alternative Medicine Review 11, 114-127.
Perrone, S., Santacroce, A., Picardi, A., Buonocore, G., 2016, Fetal programming and early identification of newborns at high risk of free radical-mediated diseases. World Journal of Clinical Pediatrics 5, 172-181.
Roysommuti, S., Lerdweeraphon, W., Michael Wyss, J., 2017, Perinatal Taurine Imbalance Followed by High Sugar Intake Alters the Effects of Estrogen on Renal Excretory Function in Adult Female Rats. Advances in Experimental Medicine and Biology 975, 769-787.
Roysommuti, S., Malila, P., Jirakulsomchok, D., Wyss, J.M., 2010, Adult renal function is modified by perinatal taurine status in conscious male rats. Journal of Biomedical Science 17 Suppl 1, S31.
Roysommuti, S., Suwanich, A., Jirakulsomchok, D., Wyss, J.M., 2009a, Perinatal taurine depletion increases susceptibility to adult sugar-induced hypertension in rats. Advances in Experimental Medicine and Biology 643, 123-133.
Roysommuti, S., Suwanich, A., Lerdweeraphon, W., Thaeomor, A., Jirakulsomchok, D., Wyss, J.M., 2009b, Sex dependent effects of perinatal taurine exposure on the arterial pressure control in adult offspring. Advances in Experimental Medicine and Biology 643, 135-144.
Sturman, J.A., 1993, Taurine in development. Physiological Reviews 73, 119-147.
Sturman, J.A., Gargano, A.D., Messing, J.M., Imaki, H., 1986, Feline maternal taurine deficiency: effect on mother and offspring. The Journal of Nutrition 116, 655-667.
Suwanich, A., Wyss, J.M., Roysommuti, S., 2013, Taurine supplementation in spontaneously hypertensive rats: Advantages and limitations for human applications. World Journal of Cardiology 5, 404-409.
Thaeomor, A., Wyss, J.M., Jirakulsomchok, D., Roysommuti, S., 2010, High sugar intake via the renin-angiotensin system blunts the baroreceptor reflex in adult rats that were perinatally depleted of taurine. Journal of Biomedical Science 17 Suppl 1, S30.
Verner, A., Craig, S., McGuire, W., 2007, Effect of taurine supplementation on growth and development in preterm or low birth weight infants. Cochrane Database of Systematic Reviews, CD006072.
Yamori, Y., Liu, L., Mori, M., Sagara, M., Murakami, S., Nara, Y., Mizushima, S., 2009, Taurine as the nutritional factor for the longevity of the Japanese revealed by a world-wide epidemiological survey. Advances in Experimental Medicine and Biology 643, 13-25.
