ภาวะหลอดเลือดดำในสมองอุดตัน
คำสำคัญ:
หลอดเลือดดำในสมองอุดตัน, ยากันเลือดเป็นลิ่ม, ปวดศีรษะบทคัดย่อ
จุดประสงค์ ภาวะหลอดเลือดดำในสมองอุดตัน (Cerebral Venous Thrombosis: CVT) เป็นโรคหลอดเลือดสมองชนิดที่พบไม่บ่อยแต่มีความเสี่ยงที่จะเกิดความพิการและเสียชีวิตสูง บทความนี้มีจุดประสงค์ เพื่อรวบรวมข้อมูลที่มีอยู่ในปัจจุบันเกี่ยวกับระบาดวิทยา การวินิจฉัย การรักษา พยากรณ์โรคของ CVT ข้อมูลที่พบ CVT มีปริมาณคิดเป็นสัดส่วน 0.5% ของผู้ป่วยหลอดเลือดสมองทั้งหมด แต่อาจวินิจฉัยได้ยาก เนื่องจากผู้ป่วยมักมาด้วยอาการปวดศีรษะมากกว่าอาการผิดปกติทางระบบประสาทเฉพาะที่ MRI และ MRV สมอง เป็นวิธีการตรวจทางรังสีเพื่อยืนยันการวินิจฉัยที่แนะนำให้ใช้เป็นลำดับแรก การรักษาหลักคือการยา กันเลือดเป็นลิ่ม ส่วนการรักษาวิธีอื่นๆนั้นมีบทบาทในกรณีที่ล้มเหลวจากการรักษาด้วยยาหรือมีภาวะแทรกซ้อน สรุป CVT เป็นโรคที่พบไม่บ่อยแต่สามารถรักษาได้ และควรคำนึงถึงไว้ด้วยเสมอในผู้ป่วยที่มาด้วยอาการ ปวดศีรษะ
เอกสารอ้างอิง
Bousser MG, Ferro JM. Cerebral venous thrombosis: an update. Lancet Neurol 2007;6:162-170.
Ferro J, Canhao P, Stam J, et al. Prognosis of cerebral vein and dural sinus thrombosis: results of the International Study on Cerebral Vein and Dural Sinus
Thrombosis (ISCVT). Stroke 2004;35:664-670.
deVeber G, Andrew M, Adams C, et al. Cerebral sinovenous thrombosis in children. N Engl J Med 2001;345:417-423.
Stam J. Thrombosis of the cerebral veins and sinuses. N Engl J Med 2005;352: 1791-1798.
Crassard I, Bousser MG. Headache in patients with cerebral venous thrombosis [in French]. Rev Neurol (Paris) 2005;161:706-708.
Girot M, Ferro JM, Canha˜o P, et al. Predictors of outcome in patients with cerebral venous thrombosis and intracerebral hemorrhage.Stroke 2007;38:337-342.
Saposnik G, Barinagarrementeria F, Brown R, et al. Diagnosis and management of cerebral venous thrombosis: a statement for healthcare professionals
from the American Heart Association/American Stroke Association.Stroke 2011;42:1158-1192.
Biousse V, Ameri A, Bousser MG. Isolated intracranial hypertension as the only sign of cerebral venous thrombosis. Neurology 1999;53:1537-1542.
Roach ES, Golomb MR, Adams R, et al. Management of stroke in infants and children: a scientific statement from a Special Writing Group of the American Heart
Association Stroke Council and the Council on Cardiovascular Disease in the Young. Stroke 2008;39:2644-2691.
Dentali F, Squizzato A, Marchesi C, et al. D-dimer testing in the diagnosis of cerebral vein thrombosis: a systematic review and a meta-analysis of the
literature. J Thromb Haemost 2012;10:582-589.
Hiltunen S, Putaala J, Haapaniemi E, et al. D-dimer and clinicoradiologic features in cerebral venous thrombosis. J Neurol Sci 2013;327:12-14.
Leach MJ, Gall SL, Dewey HM, et al. Factors associated with quality of life in 7-year survivors of stroke. J Neurol Neurosurg Psychiatry 2011;82:1365-1371.
Einha¨ upl K, Bousser MG, de Bruijn SF, et al. EFNS guideline on the treatment of cerebral venous and sinus thrombosis. Eur J Neurol 2006;13:553-559.
Leach JL, Fortuna RB, Jones BV, Gaskill-Shipley MF. Imaging of cerebral venous thrombosis: current techniques, spectrum of findings, and diagnostic pitfalls. Radiographics 2006;26:S19-S41.
Selim M, Fink J, Linfante I, et al. Diagnosis of cerebral venous thrombosis with echo-planar T2*-weighted magnetic resonance imaging. Arch Neurol 2002;59:1021-1026.
Bousser, MG, Russell, RR. Cerebral venous thrombosis. In: Warlow, CP, Van Gijn, J editors. Major Problems in Neurology. London, WB Saunders; 1997:27-104.
Sztajzel R, Coeytaux A, Dehdashti AR, et al. Subarachnoid hemorrhage: a rare presentation of cerebral venous thrombosis. Headache 2001; 41:889-891.
Oppenheim C, Domigo V, Gauvrit JY, et al. Subarachnoid hemorrhage as the initial presentation of dural sinus thrombosis. Am J Neuroradiol 2005; 26:614-617.
Spitzer C, Mull M, Rohde V, Kosinski CM. Nontraumatic cortical subarachnoid haemorrhage: diagnostic work-up and aetiological background. Neuroradiology 2005; 47:525-531.
Virapongse C, Cazenave C, Quisling R, et al. The empty delta sign: frequency and significance in 76 cases of dural sinus thrombosis. Radiology 1987;
162:779-785.
Lee EJ. The empty delta sign. Radiology 2002; 224:788-9.
Boukobza M, Crassard I, Bousser MG. When the “dense triangle” in dural sinus thrombosis is round. Neurology 2007; 69:808.
Bushnell C, Saposnik G. Evaluation and management of cerebral venous thrombosis. Continuum (Minneap Minn) 2014;20:335–351.
Wasay M, Azeemuddin M. Neuroimaging of cerebral venous thrombosis. J Neuroimaging 2005;15:118-128.
Ganeshan D, Narlawar R, McCann C, et al. Cerebral venous thrombosis-a pictorial review. Eur J Radiol 2010;74:110-116.
Coutinho JM, Ferro JM, Canha˜o P, et al. Cerebral venous and sinus thrombosis in women. Stroke 2009;40:2356-2361.
Lijfering WM, Brouwer JL, Veeger NJ, et al. Selective testing for thrombophilia in patients with first venous thrombosis: results from a retrospective family cohort
study on absolute thrombotic risk for currently known thrombophilic defects in 2479 relatives. Blood 2009;113:5314-5322.
Martinelli I, Bucciarelli P, Passamonti SM, et al. Long-term evaluation of the risk of recurrence after cerebral sinus-venous thrombosis. Circulation 2010;121:2740-2746.
Einha¨ upl KM, Villringer A, Meister W,et al. Heparin treatment in sinus venous thrombosis. Lancet 1991;338:597-600.
de Bruijn S, Stam J. Randomized,placebo-controlled trial of anticoagulant treatment with low-molecularweight heparin for cerebral sinus thrombosis. Stroke
1999;30:484-488.
Coutinho J, de Bruijn SF, Deveber G, Stam J. Anticoagulation for cerebral venous sinus thrombosis. Cochrane Database Syst Rev 2011;(8):CD002005.
Lansberg MG, O’Donnell MJ, Khatri P, et al. Antithrombotic and thrombolytic therapy for ischemic stroke: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines. Chest 2012;141:e601S-e636S.
Coutinho JM, Ferro JM, Canha˜o P, et al. Unfractionated or low-molecular weight heparin for the treatment of cerebral venous thrombosis. Stroke 2010;41: 2575-2580.
Stolz E, Trittmacher S, Rahimi A, et al. Influence of recanalization on outcome in dural sinus thrombosis: a prospective study. Stroke 2004;35:544=547.
Baumgartner RW, Studer A, Arnold M, Georgiadis D. Recanalisation of cerebral venous thrombosis. J Neurol Neurosurg Psychiatry 2003;74:459=461.
Strupp M, Covi M, Seelos K, et al. Cerebral venous thrombosis: correlation between recanalization and clinical outcome-a long-term follow-up of 40
patients. J Neurol 2002;249:1123-1124.
Coutinho JM, Ferro JM, Zuurbier SM, et al. Thrombolysis or anticoagulation for cerebral venous thrombosis: rationale and design of the TO-ACT trial. Int J Stroke 2013;8:135-140.
Borhani Haghighi A, Mahmoodi M, Edgell RC, et al. Mechanical thrombectomy for cerebral venous sinus thrombosis: a comprehensive literature review [printed
online ahead of print January 7, 2013].Clin Appl Thromb Hemost 2013. doi:10.1177/1076029612470968.
Zuurbier SM, Coutinho JM, Majoie CB, et al. Decompressive hemicraniectomy in severe cerebral venous thrombosis: a prospective case series. J Neurol 2012;259:1099-1105.
Coutinho JM, Majoie CB, Coert BA, Stam J. Decompressive hemicraniectomy in cerebral sinus thrombosis: consecutive case series and review of the literature. Stroke 2009;40: 2233-2235.
Nasr DM, Brinjikji W, Cloft HJ, et al. Mortality in cerebral venous thrombosis: results from the national inpatient sample database. Cerebrovasc Dis 2013;35:40-44.
Canha˜o P, Cortesa˜o A, Cabral M, et al. Are steroids useful to treat cerebral venous thrombosis? Stroke 2008;39:105-110.
Hanley DF, Feldman E, Borel CO, et al. Treatment of sagittal sinus thrombosis associated with cerebral hemorrhage and intracranial hypertension. Stroke 1988;19: 903-909.
Ferro JM, Lopes MG, Rosas MJ, et al; Cerebral Venous Thrombosis Portuguese Collaborative Study Group. Long-term prognosis of cerebral vein and
dural sinus thrombosis. Results of the VENOPORT study. Cerebrovasc Dis 2002;13:272-278.
Ferro J, Canhao P, Stam J, et al. Prognosis of cerebral vein and dural sinus thrombosis: results of the International Study on Cerebral Vein and Dural Sinus
Thrombosis (ISCVT). Stroke 2004;35:664-670.
deVeber G, Andrew M, Adams C, et al. Cerebral sinovenous thrombosis in children. N Engl J Med 2001;345:417-423.
Stam J. Thrombosis of the cerebral veins and sinuses. N Engl J Med 2005;352: 1791-1798.
Crassard I, Bousser MG. Headache in patients with cerebral venous thrombosis [in French]. Rev Neurol (Paris) 2005;161:706-708.
Girot M, Ferro JM, Canha˜o P, et al. Predictors of outcome in patients with cerebral venous thrombosis and intracerebral hemorrhage.Stroke 2007;38:337-342.
Saposnik G, Barinagarrementeria F, Brown R, et al. Diagnosis and management of cerebral venous thrombosis: a statement for healthcare professionals
from the American Heart Association/American Stroke Association.Stroke 2011;42:1158-1192.
Biousse V, Ameri A, Bousser MG. Isolated intracranial hypertension as the only sign of cerebral venous thrombosis. Neurology 1999;53:1537-1542.
Roach ES, Golomb MR, Adams R, et al. Management of stroke in infants and children: a scientific statement from a Special Writing Group of the American Heart
Association Stroke Council and the Council on Cardiovascular Disease in the Young. Stroke 2008;39:2644-2691.
Dentali F, Squizzato A, Marchesi C, et al. D-dimer testing in the diagnosis of cerebral vein thrombosis: a systematic review and a meta-analysis of the
literature. J Thromb Haemost 2012;10:582-589.
Hiltunen S, Putaala J, Haapaniemi E, et al. D-dimer and clinicoradiologic features in cerebral venous thrombosis. J Neurol Sci 2013;327:12-14.
Leach MJ, Gall SL, Dewey HM, et al. Factors associated with quality of life in 7-year survivors of stroke. J Neurol Neurosurg Psychiatry 2011;82:1365-1371.
Einha¨ upl K, Bousser MG, de Bruijn SF, et al. EFNS guideline on the treatment of cerebral venous and sinus thrombosis. Eur J Neurol 2006;13:553-559.
Leach JL, Fortuna RB, Jones BV, Gaskill-Shipley MF. Imaging of cerebral venous thrombosis: current techniques, spectrum of findings, and diagnostic pitfalls. Radiographics 2006;26:S19-S41.
Selim M, Fink J, Linfante I, et al. Diagnosis of cerebral venous thrombosis with echo-planar T2*-weighted magnetic resonance imaging. Arch Neurol 2002;59:1021-1026.
Bousser, MG, Russell, RR. Cerebral venous thrombosis. In: Warlow, CP, Van Gijn, J editors. Major Problems in Neurology. London, WB Saunders; 1997:27-104.
Sztajzel R, Coeytaux A, Dehdashti AR, et al. Subarachnoid hemorrhage: a rare presentation of cerebral venous thrombosis. Headache 2001; 41:889-891.
Oppenheim C, Domigo V, Gauvrit JY, et al. Subarachnoid hemorrhage as the initial presentation of dural sinus thrombosis. Am J Neuroradiol 2005; 26:614-617.
Spitzer C, Mull M, Rohde V, Kosinski CM. Nontraumatic cortical subarachnoid haemorrhage: diagnostic work-up and aetiological background. Neuroradiology 2005; 47:525-531.
Virapongse C, Cazenave C, Quisling R, et al. The empty delta sign: frequency and significance in 76 cases of dural sinus thrombosis. Radiology 1987;
162:779-785.
Lee EJ. The empty delta sign. Radiology 2002; 224:788-9.
Boukobza M, Crassard I, Bousser MG. When the “dense triangle” in dural sinus thrombosis is round. Neurology 2007; 69:808.
Bushnell C, Saposnik G. Evaluation and management of cerebral venous thrombosis. Continuum (Minneap Minn) 2014;20:335–351.
Wasay M, Azeemuddin M. Neuroimaging of cerebral venous thrombosis. J Neuroimaging 2005;15:118-128.
Ganeshan D, Narlawar R, McCann C, et al. Cerebral venous thrombosis-a pictorial review. Eur J Radiol 2010;74:110-116.
Coutinho JM, Ferro JM, Canha˜o P, et al. Cerebral venous and sinus thrombosis in women. Stroke 2009;40:2356-2361.
Lijfering WM, Brouwer JL, Veeger NJ, et al. Selective testing for thrombophilia in patients with first venous thrombosis: results from a retrospective family cohort
study on absolute thrombotic risk for currently known thrombophilic defects in 2479 relatives. Blood 2009;113:5314-5322.
Martinelli I, Bucciarelli P, Passamonti SM, et al. Long-term evaluation of the risk of recurrence after cerebral sinus-venous thrombosis. Circulation 2010;121:2740-2746.
Einha¨ upl KM, Villringer A, Meister W,et al. Heparin treatment in sinus venous thrombosis. Lancet 1991;338:597-600.
de Bruijn S, Stam J. Randomized,placebo-controlled trial of anticoagulant treatment with low-molecularweight heparin for cerebral sinus thrombosis. Stroke
1999;30:484-488.
Coutinho J, de Bruijn SF, Deveber G, Stam J. Anticoagulation for cerebral venous sinus thrombosis. Cochrane Database Syst Rev 2011;(8):CD002005.
Lansberg MG, O’Donnell MJ, Khatri P, et al. Antithrombotic and thrombolytic therapy for ischemic stroke: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines. Chest 2012;141:e601S-e636S.
Coutinho JM, Ferro JM, Canha˜o P, et al. Unfractionated or low-molecular weight heparin for the treatment of cerebral venous thrombosis. Stroke 2010;41: 2575-2580.
Stolz E, Trittmacher S, Rahimi A, et al. Influence of recanalization on outcome in dural sinus thrombosis: a prospective study. Stroke 2004;35:544=547.
Baumgartner RW, Studer A, Arnold M, Georgiadis D. Recanalisation of cerebral venous thrombosis. J Neurol Neurosurg Psychiatry 2003;74:459=461.
Strupp M, Covi M, Seelos K, et al. Cerebral venous thrombosis: correlation between recanalization and clinical outcome-a long-term follow-up of 40
patients. J Neurol 2002;249:1123-1124.
Coutinho JM, Ferro JM, Zuurbier SM, et al. Thrombolysis or anticoagulation for cerebral venous thrombosis: rationale and design of the TO-ACT trial. Int J Stroke 2013;8:135-140.
Borhani Haghighi A, Mahmoodi M, Edgell RC, et al. Mechanical thrombectomy for cerebral venous sinus thrombosis: a comprehensive literature review [printed
online ahead of print January 7, 2013].Clin Appl Thromb Hemost 2013. doi:10.1177/1076029612470968.
Zuurbier SM, Coutinho JM, Majoie CB, et al. Decompressive hemicraniectomy in severe cerebral venous thrombosis: a prospective case series. J Neurol 2012;259:1099-1105.
Coutinho JM, Majoie CB, Coert BA, Stam J. Decompressive hemicraniectomy in cerebral sinus thrombosis: consecutive case series and review of the literature. Stroke 2009;40: 2233-2235.
Nasr DM, Brinjikji W, Cloft HJ, et al. Mortality in cerebral venous thrombosis: results from the national inpatient sample database. Cerebrovasc Dis 2013;35:40-44.
Canha˜o P, Cortesa˜o A, Cabral M, et al. Are steroids useful to treat cerebral venous thrombosis? Stroke 2008;39:105-110.
Hanley DF, Feldman E, Borel CO, et al. Treatment of sagittal sinus thrombosis associated with cerebral hemorrhage and intracranial hypertension. Stroke 1988;19: 903-909.
Ferro JM, Lopes MG, Rosas MJ, et al; Cerebral Venous Thrombosis Portuguese Collaborative Study Group. Long-term prognosis of cerebral vein and
dural sinus thrombosis. Results of the VENOPORT study. Cerebrovasc Dis 2002;13:272-278.
ดาวน์โหลด
เผยแพร่แล้ว
2019-02-19
รูปแบบการอ้างอิง
1.
สุขพัลลภรัตน์ ภ. ภาวะหลอดเลือดดำในสมองอุดตัน. J Thai Stroke Soc [อินเทอร์เน็ต]. 19 กุมภาพันธ์ 2019 [อ้างถึง 30 ธันวาคม 2025];13(3):69-7. available at: https://he01.tci-thaijo.org/index.php/jtss/article/view/173164
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ประเภทบทความ
บทความวิจัย
สัญญาอนุญาต
ข้อความภายในบทความที่ตีพิมพ์ในวารสารสมาคมโรคหลอดเลือดสมองไทยเล่มนี้ ตลอดจนความรับผิดชอบด้านเนื้อหาและการตรวจร่างบทความเป็นของผู้นิพนธ์ ไม่เกี่ยวข้องกับกองบรรณาธิการแต่อย่างใด การนำเนื้อหา ข้อความหรือข้อคิดเห็นของบทความไปเผยแพร่ ต้องได้รับอนุญาตจากกองบรรณาธิการอย่างเป็นลายลักษณ์อักษร ผลงานที่ได้รับการตีพิมพ์ในวารสารเล่มนี้ถือเป็นลิขสิทธิ์ของวารสาร
