Efficacy and Safety of Dual Antiplatelet Treatment for Adult Moyamoya Disease: A Retrospective Cohort Study
Keywords:
Moyamoya, Dual antiplatelet, strokeAbstract
Introduction: Moyamoya disease is a chronic intracranial vasculopathy. Current treatment guidelines recommend antiplatelet therapy, however, there is no data about dual antiplatelet treatment in Moyamoya disease. The objective of this study was to determine the outcomes of dual antiplatelet therapy for ischemic events and death in adult Moyamoya disease.
Methods: This retrospective cohort study examined the clinical, imaging data, and clinical outcomes of ischemic stroke or transient ischemic attack patients with Moyamoya disease. Univariate analysis and multiple logistic regression model of included relevant confounders and potential predictors were performed.
Results: A total of 192 adult patients with Moyamoya disease were included in this study. Adult Moyamoya patients who received dual antiplatelet treatment had higher risk of hemorrhagic stroke than patients who received single antiplatelet treatment at 12-month follow-up (odd ratio (OR), 1.96; confidence interval (95% CI), 1.62-4.73; p<0.001), but not significant in the composite of ischemic stroke, hemorrhagic stroke, and death (odd ratio (OR), 1.23; confidence interval (95% CI), 0.86-1.44; p=0.634).
Conclusion: Adult Moyamoya patients had no potential clinical benefit from dual antiplatelet treatment with an increase in the risk of hemorrhagic stroke.
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