Ineligibility of Intravenous Thrombolysis among Activated Stroke Fast Track Patients of Khon Kaen Hospital
Keywords:
avoidable factor, ineligibility, intravenous thrombolysis, stroke fast track, unavoidable factorAbstract
Background and objective: The primary objective was to identify factors responsible for thrombolytic ineligibility. The secondary one was to determine the ratio of stroke type and stroke-mimic conditions, and to evaluate achievement of stroke fast track.
Materials and Methods: We collected all recruited stroke fast track patient data including age, gender, occupation, comorbidity, current medication, symptom onset or last-seen-normal time, vital signs, National Institutes of Health Stroke Scale (NIHSS), modified Rankin Scale (mRS), hospital arrival time, time of neurologist consultation, arrival time of neurologist, time of laboratory register and result, time of brain computed tomography (CT) request, performance and interpretation, alteplase administration and its contraindication. Statistical analysis was done appropriately.
Results: There were 181 stroke fast track candidates. One patient was referred to another tertiary hospital because of unavailable brain CT, then 180 patients were enrolled. There were 9 (5.0%) patients of stroke-mimic condition, 39 (19.44%) patients of hemorrhagic stroke, and 136 (75.56%) patients of acute ischemic stroke. Of these 136 patients, 50 (36.76%) cases received thrombolytic therapy and there were 17 (34.0%) cases had got alteplase within target (60 minutes). The avoidable ineligible factors were 2 (2.33%) delayed laboratory report, 1 (1.16%) missed neurologist consultation, delayed Door-to-Neurologist time and no decision making relative. The other unavoidable factors were 74 (86.05%) protocol exclusion, 5 (5.81%) inaccurate onset, 1 (1.16%) denial and 1 (1.16%) high risk brain CT.
Conclusion: The highlights were that most of stroke fast track patients were thrombolytic candidates. One third of them were excluded because of both avoidable and unavoidable reasons that could be resolved by further systemic development.
References
2. Hanchaiphiboolkul S, Poungvarin N, Nidhinandana S, Suwanwela NC, Puthkhao P, Towanabut S, et al. Prevalence of stroke and stroke risk factors in Thailand: Thai Epidemiologic Stroke (TES) Study. J Med Assoc Thai. 2011; 94(4): 427-36.
3. National Institute of Neurological D, Stroke rt PASSG. Tissue plasminogen activator for acute ischemic stroke. The New England journal of medicine. 1995;333(24):1581-7.
4. Hacke W, Kaste M, Bluhmki E, Brozman M, Dávalos A, Guidetti D, et al. Thrombolysis with alteplase 3 to 4.5 hours after acute ischemic stroke. N Engl J Med. 2008; 359(13): 1317-29.
5. Powers WJ, Rabinstein AA, Ackerson T, Adeoye OM, Bambakidis NC, Becker K, et al. 2018 Guidelines for the Early Management of Patients With Acute Ischemic Stroke: A Guideline for Healthcare Professionals From the American Heart Association/American Stroke Association.Stroke. 2018; 49(3): e46-e110.
6. ทัศนีย์ ตันติฤทธิศักดิ์, บรรณาธิการ. แนวทางการ รักษาโรคหลอดเลือดสมองตีบหรืออุดตันสำหรับ แพทย์. พิมพ์ครั้งที่ 2. กรุงเทพฯ: หจก. จีซัคเซส พริ้นติ้ง; 2555.
7. Pidaparthi L, Kotha A, Aleti VR, Kohat AK, Kandadai MR, Turaga S, et al. Factors influencing nonadministration of thrombolytic therapy in early arrival strokes in a university hospital in Hyderabad, India. Ann Indian Acad Neurol. 2016; 19(3): 351-5.
8. Koennecke HC, Nohr R, Leistner S, Marx P. Intravenous tPA for ischemic stroke team performance over time, safety, and efficacy in a single-center, 2-year experience. Stroke. 2001; 32(5): 1074-8.
9. Katzan IL, Furlan AJ, Lloyd LE, Frank JI, Harper DL, Hinchey JA, et al. Use of tissue-type plasminogen activator for acute ischemic stroke: the Cleveland area experience. JAMA. 2000; 283(9): 1151-8.
10. Barber PA, Zhang J, Demchuk AM, Hill MD, Buchan AM. Why are stroke patients excluded from TPA therapy? An analysis of patient eligibility. Neurology. 2001; 56(8): 1015-20.
11. Van den Berg JS, de Jong G. Why ischemic stroke patients do not receive thrombolytic treatment: results from a general hospital. Acta Neurol Scand. 2009; 120(3): 157-60.
12. Cocho D, Belvís R, Martí-Fàbregas J, Molina-Porcel L, Díaz-Manera J, Aleu A, et al. Reasons for exclusion from thrombolytic therapy following acute ischemic stroke. Neurology. 2005; 64(4): 719-20.
13. O’Connor RE, McGraw P, Edelsohn L. Thrombolytic therapy for acute ischemic stroke: why the majority of patients remain ineligible for treatment. Ann Emerg Med. 1999; 33(1): 9-14.
14. Hosseininezhad M, Sohrabnejad R. Stroke mimics in patients with clinical signs of stroke. Caspian J Intern Med. 2017; 8(3): 213-6.
15. Dupre CM, Libman R, Dupre SI, Katz JM, Rybinnik I, Kwiatkowski T. Stroke chameleons. J Stroke Cerebrovasc Dis. 2014; 23(2): 374-8.
16. Hand PJ, Kwan J, Lindley RI, Dennis MS, Wardlaw JM. Distinguishing between stroke and mimic at the bedside: the brain attack study. Stroke. 2006; 37(3): 769-75.
17. Kose A, Inal T, Armagan E, Kıyak R, Demir AB. Conditions that mimic stroke in elderly patients admitted to the emergency department. J Stroke Cerebrovasc Dis. 2013; 22(8): e522-7.
18. Vilela P. Acute stroke differential diagnosis: Stroke mimics. Eur J Radiol. 2017; 96: 133-44.
19. Fernandes PM, Whiteley WN, Hart SR, Al-Shahi Salman R. Strokes: mimics and chameleons. Pract Neurol. 2013; 13(1): 21-8.
20. Jauch EC, Saver JL, Adams HP, Bruno A, Connors JJ, Demaerschalk BM, et al. Guidelines for the early management of patients with acute ischemic stroke: a guideline for healthcare professionals from the American Heart Association/American Stroke Association. Stroke. 2013; 44(3): 870947.
21. Wijdicks EF, Sheth KN, Carter BS, Greer DM, Kasner SE, Kimberly WT, et al. Recommendations for the management of cerebral and cerebellar infarction with swelling: a statement for healthcare professionals from the American Heart Association/American Stroke Association. Stroke. 2014; 45(4): 1222-38.
22. Patel SC, Levine SR, Tilley BC, Grotta JC, Lu M, Frankel M, et al. Lack of clinical significance of early ischemic changes on computed tomography in acute stroke. JAMA. 2001; 286(22): 2830-8.
23. Hacke W, Kaste M, Fieschi C, Toni D, Lesaffre E, von Kummer R, et al. Intravenous thrombolysis with recombinant tissue plasminogen activator for acute hemispheric stroke. The European Cooperative Acute Stroke Study (ECASS). JAMA. 1995; 274(13): 1017-25.
24. C RM, George B, Lawrence B, J.M. BA, David DA, Mary d, et al. Standards of medical care in diabetes 2018. Diabetes Care. 2018; 41: S61.
25. Sridharan SE, Unnikrishnan JP, Sukumaran S, Sylaja PN, Nayak SD, Sarma PS, et al. Incidence, types, risk factors, and outcome of stroke in a developing country: the Trivandrum Stroke Registry. Stroke. 2009; 40(4): 1212-8.
26. Nilanont Y, Nidhinandana S, Suwanwela NC, Hanchaiphiboolkul S, Pimpak T, Tatsanavivat P, et al. Quality of acute ischemic stroke care in Thailand: a prospective multicenter countrywide cohort study. J Stroke Cerebrovasc Dis. 2014; 23(2): 213-9.
27. Kistler JP. The risk of embolic stroke. Another piece of the puzzle. N Engl J Med. 1994; 331: 1517-9.
28. Arboix A, Alió J. Cardioembolic stroke: clinical features, specific cardiac disorders and prognosis. Curr Cardiol Rev. 2010; 6(3): 150-61.
29. Adams HP, Davis PH, Leira EC, Chang KC, Bendixen BH, Clarke WR, et al. Baseline NIH Stroke Scale score strongly predicts outcome after stroke: A report of the Trial of Org 10172 in Acute Stroke Treatment (TOAST). Neurology. 1999; 53(1): 126-31.
30. Dharmasaroja PA, Muengtaweepongsa S, Pattaraarchachai J, Dharmasaroja P. Intracerebral hemorrhage following intravenous thrombolysis in Thai patients with acute ischemic stroke. J Clin Neurosci. 2012; 19(6): 799-803.
31. Weisscher N, Vermeulen M, Roos YB, de Haan RJ. What should be defined as good outcome in stroke trials; a modified Rankin score of 0-1 or 0-2? J Neurol. 2008; 255(6): 867-74.
32. Committee ESOEE, Committee EW. Guidelines for management of ischaemic stroke and transient ischaemic attack 2008. Cerebrovasc Dis. 2008; 25(5): 457-507.
33. Salintip K, Pawut M. Factors Associated with Symptomatic Intracerebral Hemorrhage after Thrombolytic Therapy in Acute Ischemic Stroke. Thai Journal of Neurology. 2014; 30: 16-23.
34. Rodríguez-Rivera IV, Santiago F, Estapé ES, González-Sepúlveda L, Brau R. Impact of Day of the Week and Time of Arrival on Ischemic Stroke Management. P R Health Sci J. 2015; 34(3): 164-9.
35. Palumbo V, Boulanger JM, Hill MD, Inzitari D, Buchan AM, Investigators C. Leukoaraiosis and intracerebral hemorrhage after thrombolysis in acute stroke. Neurology. 2007; 68(13): 1020-4.
36. Pantoni L, Fierini F, Poggesi A. Thrombolysis in acute stroke patients with cerebral small vessel disease. Cerebrovasc Dis. 2014; 37(1): 5-13.
37. Charidimou A, Pasi M, Fiorelli M, Shams S, von Kummer R, Pantoni L, et al. Leukoaraiosis, Cerebral Hemorrhage, and Outcome After Intravenous Thrombolysis for Acute Ischemic Stroke: A Meta-Analysis (v1). Stroke. 2016; 47(9): 2364-72.
38. Saulle MF, Schambra HM. Recovery and Rehabilitation after Intracerebral Hemorrhage. Semin Neurol. 2016; 36(3): 306-12.
39. Fogelholm R, Murros K, Rissanen A, Avikainen S. Long term survival after primary intracerebral haemorrhage: a retrospective population based study. J Neurol Neurosurg Psychiatry. 2005; 76(11): 1534-8.
40. Paolucci S, Antonucci G, Grasso MG, Bragoni M, Coiro P, De Angelis D, et al. Functional outcome of ischemic and hemorrhagic stroke patients after inpatient rehabilitation: a matched comparison. Stroke. 2003; 34(12): 2861-5.
Downloads
Published
How to Cite
Issue
Section
License
ข้อความภายในบทความที่ตีพิมพ์ในวารสารสมาคมโรคหลอดเลือดสมองไทยเล่มนี้ ตลอดจนความรับผิดชอบด้านเนื้อหาและการตรวจร่างบทความเป็นของผู้นิพนธ์ ไม่เกี่ยวข้องกับกองบรรณาธิการแต่อย่างใด การนำเนื้อหา ข้อความหรือข้อคิดเห็นของบทความไปเผยแพร่ ต้องได้รับอนุญาตจากกองบรรณาธิการอย่างเป็นลายลักษณ์อักษร ผลงานที่ได้รับการตีพิมพ์ในวารสารเล่มนี้ถือเป็นลิขสิทธิ์ของวารสาร