Lung cancer radiotherapy using end expiration breath hold technique with respiratory gating for scanners (RGSC) and linear accelerator at Siriraj hospital

Authors

  • Favalai Pongpaiboon Division of Radiation Oncology, Department of Radiology, Faculty of Medicine Siriraj Hospital, Mahidol University
  • Korakot Soonthonchainukul Division of Radiation Oncology, Department of Radiology, Faculty of Medicine Siriraj Hospital, Mahidol University
  • Kotchakorn Assawasuphachai Division of Radiation Oncology, Department of Radiology, Faculty of Medicine Siriraj Hospital, Mahidol University
  • Jularat Suebsom Division of Radiation Oncology, Department of Radiology, Faculty of Medicine Siriraj Hospital, Mahidol University

Keywords:

End expiration breath hold, radiation therapy, lung cancer, breathing, reproducibility

Abstract

Respiratory motion, or lung movement resulting from breathing, is an important factor that causes uncertainty in the target position during radiation treatment for lung cancer, and may affect the accuracy and safety of the treatment. This article presents technical and practical guidelines for radiation treatment of lung cancer using the end-expiration breath-hold (EEBH) technique with respiratory gating for scanners (RGSC) and a linear accelerator, covering the patient selection process and preparation procedures, including breath-hold training, computed tomography simulation (CT simulation) under EEBH conditions, and advanced radiation therapy planning. Additionally, it encompasses the process of radiation delivery and position monitoring using kV-kV and cone beam CT (CBCT) images to ensure the consistency of the patient’s radiation position in clinical settings. Furthermore, it discusses the considerations for using EEBH techniques in medical practice, such as patient cooperation, reproducibility of breath holding, pre-treatment training, and position monitoring in each fraction to maintain the quality and safety of treatment. Therefore, these guidelines are technical reports and medical practice. These are not evaluating comparative results. However, this article can serve as a reference guide for radiotherapy treatment workflows in institutions with similar resources and technology.

References

Li C, Lei S, Ding L, Xu Y, Wu X, Wang H, et al. Global burden and trends of lung cancer incidence and mortality. Chin Med J (Engl). 2023;136: 1583-90.

Virani S, Bilheem S, Chansaard W, Chitapanarux I, Daoprasert K, Khuanchana S, et al. National and subnational population-based incidence of cancer in Thailand: Assessing cancers with the highest burdens. Cancer Epidemiol. 2017;50:119-27.

Phacharoen U, Taseeruan W, Niyomthong P, Chattrapiban T. Trends in particulate matter levels and lung cancer incidence rate in phrae province, Northern Thailand: A 10-Year Retrospective Study. Phrae Med J Clin Sci. 2025;33:14-25.

ณิชา ซึงสนธิพร. การรักษาโรคมะเร็งปอดด้วยยา (Systemic therapy) [Internet]. กรุงเทพฯ: หน่วยมะเร็งวิทยา โรงพยาบาลจุฬาลงกรณ์; 2023 Nov 14 [cited 2025 Aug 26]. Available from: https://kcmh.chulalongkornhospital.go.th/line/การรักษาโรคมะเร็งปอดด้/

Abdul Ghani MNH, Ng WL. Management of respiratory motion for lung radiotherapy: a review. J Xiangya Med. 2018;3:27.

Botticella A, Levy A, Auzac G, Chabert I, Berthold C, Le Pechoux C. Tumour motion management in lung cancer: a narrative review. Transl Lung Cancer Res. 2021;10:2011-7.

Nguanthean W, Wong S. Knowledge for radiotherapists about stereotactic body radiotherapy for lung lesions. J Thai Assn Radiat Oncol. 2022;28:O1-O13.

Guberina M, Santiago A, Pöttgen C, Eich HT, Kriz J, Husmann G, et al. Respiration-controlled radiotherapy in lung cancer: Systematic evaluation of the optimal application practice. Clin Transl Radiat Oncol. 2023;40:100628.

Mayhew C, Venkatasai J, Khan M, Leung B, Owczarczyk K, Ntentas G. Dosimetric and volumetric effects of end expiration breath hold radiotherapy for oesophageal cancer. Presented at: ESTRO 2023; 2023 May 15-19; Vienna, Austria.

Mayhew C, Venkatasai J, Khan M, Butterworth V, Owczarczyk K, Ntentas G. Effect of end expiration breath hold on target volumes and organ at risk doses for oesophageal cancer radiotherapy. Phys Imaging Radiat Oncol. 2025;33:100726.

Shi C, Tang X, Chan M. Evaluation of the new respiratory gating system. Precis Radiat Oncol. 2017;1:127-33.

Liu B, Shi C, Prakash M, Gonzalez B, Kassardjian A, Kim J, et al. Comparison of baseline drifts using three reflector blocks versus using a single reflector block for the calibration of wall-mounted Respiratory Gating for Scanner (RGSC) camera integrated with a CT. J Appl Clin Med Phys. 2023;24:e14199.

Oh SA, Yea JW, Kim SK. Statistical determination of the gating windows for respiratory gated radiotherapy using a visible guiding system. PLoS ONE. 2016;11:e0156357.

Introducing RGSC 1.0 – Varian's new gating solution for CT scanners [Internet]. Vienna: Gesundheitsverbund; 2015 Mar 7 [cited 2025 Aug 28]. Available from: https://physik.gesundheitsverbund.at/rgsc/rgsc_intro.htm

Varian Medical Systems. Respiratory Gating for Scanners (RGSC) Product Planning Guide [Internet]. Palo Alto (CA): Varian Medical Systems; 2021 Feb [cited 2025 Aug 28]. Available from: https://firebasestorage.googleapis.com/v0/b/meps-fbase-prod-1.appspot.com/o/mft-items%2F66e0ff85-8a5f-4675-bc66-daab842a9010%2Fcutsheets%2FVarian-1730378598293.pdf?alt=media&token=6f39ad15-3aac-498e-a02b-582f5b433810

Timmerman R, Paulus R, Galvin J, Michalski J, Straube W, Bradley J, et al. Stereotactic Body Radiation Therapy for Inoperable Early-Stage Lung Cancer. JAMA. 2010;303:1070-6.

Guckenberger M, Wilbert J, Krieger T, Richter A, Baier K, Meyer J, et al. Motion management in stereotactic body radiotherapy for pulmonary tumors — Review of procedures and clinical evidence. Radiother Oncol. 2012;102: 168-74.

Guckenberger M, Andratschke N, Dieckmann K, Hoogeman MS, Hoyer M, Hurkmans C, et al. ESTRO ACROP consensus guideline on implementation and practice of stereotactic body radiotherapy for peripherally located early stage non-small cell lung cancer. Radiother Oncol. 2017;124: 11-7.

Uttumporn P, Plianaram S, Pongprapan W, Thanunphuwasit U, Yamchaisarn C, Pongpaiboon F, et al. Stereotactic Body Radiotherapy in lung cancer and lung metastases patient at Siriraj hospital. J Thai Assn Radiat Oncol. 2022;28: 56-69.

Keall PJ, Mageras GS, Balter JM, Emery RS, Forster KM, Jiang SB, et al. The management of respiratory motion in radiation oncology: Report of AAPM Task Group 76. Med Phys. 2006;33: 3874-900.

Varian Medical Systems, Inc. Gating Files Workflow Workbook: RGSC and RPM with ARIA, Clinac, and TrueBeam Platform. Palo Alto (CA): Varian Medical Systems; 2018.

Farrugia B, Brown K, Knight K, Wright C. A systematic review of tumour position reproducibility and stability in breath-hold for radiation therapy of the upper abdomen. Phys Imaging Radiat Oncol. 2025;34:100751.

Koch S, Bremer M, Lettmaier S, Strober R, Semrau S, Weissmann T, et al. Patient compliance in breath-hold based radiation therapy. Strahlenther Onkol. 2020;196: 640-7.

Kittiva N, Khamfongkhruea C, Chamchod S, Paduka S, Liamsuwan T. Optimal gating window for respiratory gated pencil beam scanning proton therapy for lung cancer: a pilot study. J Thai Assn Radiat Oncol. 2021;27: R60-R75.

Yang S, Su B, Liu H. Quantitative evaluation of accumulated and planned dose deviations in patients undergoing gated and non-gated lung stereotactic body radiation therapy patients: a retrospective analysis. Transl Lung Cancer Res. 2024;13:3616-28.

Downloads

Published

2026-06-25

How to Cite

1.
Pongpaiboon F, Soonthonchainukul K, Assawasuphachai K, Suebsom J. Lung cancer radiotherapy using end expiration breath hold technique with respiratory gating for scanners (RGSC) and linear accelerator at Siriraj hospital. J Thai Assn of Radiat Oncol [internet]. 2026 Jun. 25 [cited 2026 Jul. 5];32(1):O16-O33. available from: https://he01.tci-thaijo.org/index.php/jtaro/article/view/282623

Issue

Section

Review articles