Effect of topical vitamin E on radiation induced skin alteration in head and neck cancer patients Supported by The Ratchadapiseksompotch Fund Year 2003, Chulalongkorn University
Abstract
Purpose: This study was initiated to evaluate the effect of topical vitamin E on the reduction of ionizing
radiation induced skin reaction in head and neck cancer patients compared to placebo and the
reliability of the application in clinical practice.
Setting: Division of Radiation Oncology, Department of Radiology, King Chulalongkorn Memorial Hospital
Research design: Prospective randomized controlled trial
Patients and Methods: The study started from December 1, 2002 to July 31, 2003. There were 29 eligible patients. The applications of vitamin E cream and placebo were done in the same patients on each side of the face and neck areas that were irradiated, left / right. The application of both cream were randomized and without naming the drugs on the tube, colored tape were used to suggest the drug applications for preventing any bias. The drug applications have been done starting from the 1" week of the initiation of radiation, applied everyday, 2 times per day until the radiation dose reached Gy . The skin was evaluated by the same person in the 1" week of radiation and then weekly during irradiation period until the dose of radiation reached 50 Gy.
Results: The results show no significant statistical difference of the skin reaction to ionizing radion of irradiated areas that were applied with topical vitamin E compared to placebo, evaluated under the same clinical criteria (CTC version 2.0) (p 1.00)
Conclusion: From the data, it cannot be concluded whether or not the anti-free radical effect of vitamin E can reduce tissue injury from ionizing radiation. However, from the clinical criteria, it may be initially concluded that the topical vitamin E cream does not make any difference of skin alteration caused by ionizing radiation when compared to the placebo; and there is no benefit of topical vitamin E applications in clinical practice.
References
Ellen Sitton. Early and late radiation-induced skin alteration : mechanism of skin change. Oncology Nursing Forum 1992; 19 : 801-807
Ellen sitton. Early and late radiation-induced skin alteration : Nursing care of irradiated skin. Oncology Nursing Forum 1992; 19 : 907-912
Trevithick, J.R., et. al. Reduction of sunburn damage to skin by topical application of vitamin E acetate following exposure to ultraviolet B radiation : effect of delaying application or of reducing concentration of vitamin E acetate applied. Scanning. Microscopy 1993; 17 : 1296-1281
Trevithick, J.R., et .al. Topical tocopherol acetate reduces post-UVB, sunburn associated erythema, edema and skin sensitivity in hairless mice. Arch.Biochem.Biopsy 1992 ; 296 : 575-582
Darr, D., Dunston et al. Effectiveness antioxidant (vitamin C and E) with and without sunscreen as topical photoprotectants. Acta.Derm.Venerol (Stock) 1996 ;74 : 264-268
Bissett, D.L. et al. Photoprotective effect of superoxide scavening antioxidant against ultraviolet radiation- induced chronic skin change in the hairless mouse. Photodermatol.Photoimmunol.Photomed.1990 ; 7 : 56-62
Chalisa Savansan. The effect of topical vitamin C, vitamin E and indomethacin on Uvb-induced erythema. A thesis Submitted in Partial Fulfillment of the Requirement for the Degree of Master of Science in Medicine : 1998
Stewate, m.s.. et. al. Antioxidant nutrient protect against UVB-induced oxidative damage to DNA of mouse keratinocytes in culture. J.invest.Dermatol.1996; 106 : 1086-1089
Frayer,M.J. 1993. Evidence for the photoprotective effect of vitamin E. Photochem. Photobiol. 58:304- 312
Chan.A.C. 1992. Partners in defense, vitamin E and vitamin C. Can.J. Physiol. Pharmacol. 71:725-731
http://www.lef.org/prod-hp/abstracts/php-ab426.html
Leslie S. Baumann, MD, and James Spencer MD, MS. 1999. The Effect of Topical Vitamin E on the Cosmetic Appearance of Scar. Dermatolol Surg; 25:311- 315
Margolin SG, et al. Management of radiation-induced moist skin desquamation using hydrocolloid dressing. Cancer Nurs 1990 Apr;13 (2):71-80
Downloads
Published
How to Cite
Issue
Section
License
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
บทความที่ได้รับการตีพิมพ์เป็นลิขสิทธิ์ของวารสารมะเร็งวิวัฒน์ ข้อความที่ปรากฏในบทความแต่ละเรื่องในวารสารวิชาการเล่มนี้เป็นความคิดเห็นส่วนตัวของผู้เขียนแต่ละท่านไม่เกี่ยวข้องกับ และบุคคลากรท่านอื่น ๆ ใน สมาคมฯ แต่อย่างใด ความรับผิดชอบองค์ประกอบทั้งหมดของบทความแต่ละเรื่องเป็นของผู้เขียนแต่ละท่าน หากมีความผิดพลาดใดๆ ผู้เขียนแต่ละท่านจะรับผิดชอบบทความของตนเองแต่ผู้เดียว
