Low dose preoperative and selective high dose postoperative radiation therapy for rectal cancer

Authors

  • Thiti Swangsilpa Department of Radiation Oncology, Pramongkutklao Hospital
  • Pramook Phromratanapongse Department of Radiation Oncology, Pramongkutklao Hospital
  • Pomsri Kidchob Department of Radiation Oncology, Pramongkutklao Hospital
  • Suneerat Sangvirojkul Department of Radiation Oncology, Pramongkutklao Hospital
  • Chanawat Tesavibul Department of Radiation Oncology, Pramongkutklao Hospital
  • Nathsith Yamyim Department of Radiation Oncology, Pramongkutklao Hospital
  • Chatrachai Tasaniyananda Department of Surgery, Pramongkutklao Hospital
  • Parinya Thavichaigarn Department of Surgery, Pramongkutklao Hospital

Abstract

Twenty six patients with adenocarcinoma of the rectum were entered in a program of adjuvant "sandwich irradiation" at Pramongkutklao hospital. All patients were given a single dose of preoperative radiation 500 cGy one day before surgery. After surgical staging, the patients who had diseases beyond stage B1 (modified Astler-Coller staging) would receive postoperative radiation 4500-5400 cGy. Twenty one patients received full course of this treatment regimen, but only 16 patients could be followed up after completion of treatment. The mean follow up time was 35 months. The 2-year and 4-year Kaplan-Meier actuarial survival were 74% and 44% respectively. No severere treatment-related complication has been observed.

References

Perez CA, Brady LW. Principles and practice of radiation oncology; 2nd edition, 1992. Philadelphia, Lippincott: 1000-14.

Cummings B.J. Adjuvant radiation therapy for colorectal cancer. Cancer 1992; 70(Suppl.):1372-83.

Nias AH. Radiobiological aspects of preoperative irradiation Br J Radiol. 1967; 40: 166-9.

Rider WD. Is the miles operation really necessary for the treatment of rectal cancer. J Can Assoc. Radiol. 1975; 26:167-75.

MRC working party A trial of preoperative radiotherapy in the management of operable rectal cancer. Br J Surg.1982:69:513-9.

MRC working party. The evaluation of low dose preoperative X-ray therapy in the management of operable rectal cancer; results of a randomly controlled trial. Br J Surg. 1984; 71:21-5.

Gunderson LL., Dosoretz DE, Hedbeg ES., et al. Low dose preoperative irradiation, surgery, and elective postoperative radiation therapy for resectable rectum and rectosigmoid carcinoma.Cancer 1983;52:446-51.

Sause WT, Martz KL, Noyes D,et al. RTOG 81-15 ECOG 83-23 evaluation of preoperative radiation therapy in operable rectal carcinoma. Int. J Radiat. Oncol. Biol. Phys.1990; 19 (suppl.): 179.

Lingareddly V., Mohiuddin M., Marks G. Long term results of "selective sandwich" adjunctive radiotherapy of cancer of the rectum. Int. I Radiat. Oncol. Biol. Phys. 1990; 19 (suppl.): 179.

Mohiuddin M., Lingareddly V. Marks G., Long term results of "selective sandwich" adjunctive radiotherapy for cancer of the rectum. Am. J. Clin. Oncol. 1994 ; 17 (3): 264-8.

Downloads

Published

2025-01-22

How to Cite

1.
Swangsilpa T, Phromratanapongse P, Kidchob P, Sangvirojkul S, Tesavibul C, Yamyim N, Tasaniyananda C, Thavichaigarn P. Low dose preoperative and selective high dose postoperative radiation therapy for rectal cancer. J Thai Assn of Radiat Oncol [internet]. 2025 Jan. 22 [cited 2025 Dec. 26];4(1):7-13. available from: https://he01.tci-thaijo.org/index.php/jtaro/article/view/276757

Issue

Vol. 4 No. 1 (1998): January - April

Section

Original articles

License

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

บทความที่ได้รับการตีพิมพ์เป็นลิขสิทธิ์ของวารสารมะเร็งวิวัฒน์ สมาคมรังสีรักษาและมะเร็งวิทยาแห่งประเทศไทย

ข้อความที่ปรากฏในบทความแต่ละเรื่องในวารสารวิชาการเล่มนี้เป็นความคิดเห็นส่วนตัวของผู้เขียนแต่ละท่านไม่เกี่ยวข้องกับสมาคมรังสีรักษาและมะเร็งวิทยาแห่งประเทศไทย และบุคคลากรท่านอื่น ๆ ใน สมาคมฯ แต่อย่างใด ความรับผิดชอบองค์ประกอบทั้งหมดของบทความแต่ละเรื่องเป็นของผู้เขียนแต่ละท่าน หากมีความผิดพลาดใดๆ ผู้เขียนแต่ละท่านจะรับผิดชอบบทความของตนเองแต่ผู้เดียว