Radiation therapy combined with hyperthermia and chemotherapy for the treatment of orbital metastesis in breast Cancer : a case report.

Authors

  • Pittayapoom Pattaranutaporn Div. of Radiation Oncology, Dept. of Radiology Faculty of Medicine, Siriraj Hosp., Mahidol University
  • Yaowalak Chansilpa Div. of Radiation Oncology, Dept. of Radiology Faculty of Medicine, Siriraj Hosp., Mahidol University
  • Nan Suntornpong Div. of Radiation Oncology, Dept. of Radiology Faculty of Medicine, Siriraj Hosp., Mahidol University
  • Nuanpen Damrongkitudom Div. of Radiation Oncology, Dept. of Radiology Faculty of Medicine, Siriraj Hosp., Mahidol University

Abstract

A case report of breast cancer patient who suffered from exopthalmos with severere pain of right eye due to metastasis to the right orbit. The disease extended to frontotemporal part of scalp with intracranial extension to frontal part of brain parenchyma. The local treatment was external irrediation to right eyes included frontotemporal region of the scalp and intracranial lesion. Three hyperthemic treatments were combined because the tumor showed no response at the dose of 3600 cGy. After the completion of irradiation conjuncted with hyperthermia, the tumor showed partial response to the treatment. The further treat-ment was hyperthermia combined with chemo-therapy (CAF regimen) once a month for three months. The result was very good. Exophthalmos disappeared and pain symptom was relieved without any severe complications.

References

Jacobs M, Benger R. : Metastasis breast carcinoma of the orbit. Aust NZ J Opthalmol. 1989 ; 17 :357-361.

Perez CA, Garcia DM, Kuske RR, et al. Breast :Stage T, and T, tumors. In : Perez CA, Brady AW.eds. Principles and Practice of Radiation Oncology.2880.

Glazer LC, Harris GJ, Simons KB. Orbital metastasis as the presenting sign of the breast. Ophthal Plast Reconstr Surg 1991 ; 7 : 252-255.

Stefanyszyn MA, DeVita EG, Flanagen JC. Breast carcinoma metastatic to the orbit. Ophthal Plast Reconstr Surg 1987 ; 3 : 43-47.

van der Heijden A, Twijnstra A, Lamers WP, et al. An unusual cause of diplopia in a cancer patient. Eur J Cancer 1991 ; 27 : 1315-1316.

Burmeister BH, Benjamin CS, Childs WJ. The management of metastases to eye and orbit from carcinoma of the breast. Aust NZ J phthalmol

; 18 : 187-190.

Motto-Lippa L, JaKobiec FA, Iwamoto T. Pscudo-inflammatory metastatic breast carcinoma of the orbit and lids. Ophthalmology 1981 ; 88 : 575-580.

Hesselink JR, Davis KR, Weber AL, et al. Radio-logical evaluation of orbital metastases with emphasis on computed tomography. Radiology 1984 ; 37 :363-366.

Healy JF. Computed tomographic evaluation of metastases to the orbit. Ann Ophthalmol 1983 ; 15 :1026-1029.

Font RI, Ferry AP. Carcinoma metastatic to the eye and orbit. III A clinicopathological study of 28 cases metastatic to orbit. Cancer 1966 ; 38 : 1326-1335.

Kagen AR. Radiation therapy in palliative cancer management. In : Perez CA, Brady AW. eds. Prin-ciples and Practice of Radiation Oncology. 2" ed. Philadelphia : JB Lippincott company, 1992 : 1498.

Dobrowsky W. Treatment of choroid metastasis. Br J Radiol 1988 ; 61 : 140-142.

Sagerman RH. Radiation therapy for orbital tamor. In : Hornblass A. ed. Tumor of the ocular adnexa and orbit. St. Louis : The CV Mosby, 1979 : 268.

Huh SH, Nisce LZ, Simpson L.D, et al. Vaiue of radiation therapy in the treatment of orbital meta-stasis. AJR 1974 ; 120 : 589-594.

Panizzoni GA, Gasparini G, Dal Fior S, et al, Radio-therapeutic treatment for breast cancer choroidal metastasis. Tumori 1990 ; 76 : 563-565.

Hoogenhout J, Brink HM, Verbuk AM, et al. Radio-therapy of choroidal metastasis. Strahlentherapic and Onkologie 1989 ; 165 : 375-379.

Withers HR, Peters LJ. Basic principle of radio-therapy. In : Fletcher GH. ed. Textbook of Radio-therapy. 3' ed. Philadelphia : Lea & Febiger. 1980 :192-199.

Scott RS, Richard JR, Story KV, et al. : Local hyper-thermia in combination with definitive radiotherapy : Increased tumor clearance, reduced recurrence rate in extended follow up. Int J Radiat Oncol biol Phys 1984 ; 10 : 2119-2123.

Dunlop PRC, Hand JW, Dickinson RJ, et al. An assessment of local hyperthermia in clinical practice. Int J Hyperthermia 1986 ; 2 : 39-50.

Gonzales DG, van Dijk JDP, Blank LECM. Chest wall recurrence of breast cancer : Result of combined treatment with radiation and hyperthermia. Radio-therapy and oncology 1988 ; 12 : 95-103.

Li RY, Wang HP, Lin SY, et al. Clinical eval uation of combined radiotherapy and thermotherapy on carcinoma on carcinoma of the breast (in Chinese).Clin Oncol 1985 ; 12 : 73-76.

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Published

2025-01-09

How to Cite

1.
Pattaranutaporn P, Chansilpa Y, Suntornpong N, Damrongkitudom N. Radiation therapy combined with hyperthermia and chemotherapy for the treatment of orbital metastesis in breast Cancer : a case report. J Thai Assn of Radiat Oncol [internet]. 2025 Jan. 9 [cited 2025 Dec. 25];1(1):10-6. available from: https://he01.tci-thaijo.org/index.php/jtaro/article/view/275555

Issue

Vol. 1 No. 1 (1995): January - April

Section

Case Reports

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บทความที่ได้รับการตีพิมพ์เป็นลิขสิทธิ์ของวารสารมะเร็งวิวัฒน์ สมาคมรังสีรักษาและมะเร็งวิทยาแห่งประเทศไทย

ข้อความที่ปรากฏในบทความแต่ละเรื่องในวารสารวิชาการเล่มนี้เป็นความคิดเห็นส่วนตัวของผู้เขียนแต่ละท่านไม่เกี่ยวข้องกับสมาคมรังสีรักษาและมะเร็งวิทยาแห่งประเทศไทย และบุคคลากรท่านอื่น ๆ ใน สมาคมฯ แต่อย่างใด ความรับผิดชอบองค์ประกอบทั้งหมดของบทความแต่ละเรื่องเป็นของผู้เขียนแต่ละท่าน หากมีความผิดพลาดใดๆ ผู้เขียนแต่ละท่านจะรับผิดชอบบทความของตนเองแต่ผู้เดียว