The comparison of late complications between 2D conventional radiotherapy and 3D conformal radiotherapy with adjuvant chemotherapy for patients with rectal cancer in Siriraj Hospital

Authors

  • Vutisiri Veerasarn Division of Radiation Oncology, Department of Radiology, Faculty of Medicine Siriraj Hospital, Mahidol University.
  • Pentipa Sereepitakkul Division of Radiation Oncology, Department of radiology, Hatyai Hospital

Keywords:

rectal cancer, 2D radiotherapy, 3D conformal radiotherapy, late complication

Abstract

Background: The transition of adjuvant radiotherapy techniques in treating locally advanced rectal cancer had been developed from 2-dimension conventional radiotherapy (2D-RT) to 3-dimensional conformal radiotherapy (3D-CRT). Theoretically, the 3D-CRT technique showed the advantage of more target dose coverage in treating field and lessen normal tissue toxicity compared to 2D-RT technique.

Objectives: To compare late radiation complications and quality of life (QoL) between patients receiving 2D-RT and 3D-CRT.

Materials and Methods: Locally advanced rectal cancer patients (T2-4 and/or lymph node positive), who received adjuvant either pre- or post-operative concurrent chemoradiotherapy between January 2012 and December 2018, were divided into 2 treatment groups: 2D-RT or 3D-CRT. After long term follow-up, we evaluated the late radiation complications using the RTOG/EORTC Late Radiation Morbidity Scoring Schema, and the QoL using the FACT-C Questionnaires, version 4.

Results: 235 locally advanced rectal cancer patients, (2D-RT; n = 62 and 3D-CRT; n = 173), were enrolled in this study. The median follow-up time was 4.92 years in 2D-RT group vs. 2.18 years in 3D-CRT group. There was no significant difference in late small / large intestine and bladder complications between 2 treatment groups. However, the QoL measurement showed better scores in longer follow-up time.

Conclusion: The longer follow-up periods had a significant impact on greater daily living. While there was no difference in late small / large intestine and bladder complications between both radiation techniques.

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Published

2021-09-09

How to Cite

1.
Veerasarn V, Sereepitakkul P. The comparison of late complications between 2D conventional radiotherapy and 3D conformal radiotherapy with adjuvant chemotherapy for patients with rectal cancer in Siriraj Hospital. J Thai Assn of Radiat Oncol [Internet]. 2021 Sep. 9 [cited 2024 Mar. 29];27(2):R27-R42. Available from: https://he01.tci-thaijo.org/index.php/jtaro/article/view/249426

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Original articles