Accuracy evaluation of image-guided radiation therapy guided by optical surface monitoring system for treatment of intracranial tumors
Keywords:
Image-guided radiation therapy, IGRT, intracranial tumors, optical surface monitoring system, OSMSAbstract
Background: Image-guided radiation therapy (IGRT) is an advanced radiation treatment that creates an image of the tumor to guide the radiation beam during radiation therapy. Importantly, the use of ionizing radiation for daily IGRT may subject patients to an unnecessarily cumulative dose of radiation. The optical surface monitoring system (OSMS) is a non-ionizing radiation IGRT technique that was developed to provide continuous motion tracking during real-time treatment without increasing patient exposure to ionizing radiation.
Objective: The aim of this study was to investigate the accuracy of IGRT guided by OSMS for the treatment of intracranial tumors.
Materials and Methods: This retrospective analysis of prospectively collected data included 62 consecutive patients that were treated for intracranial brain tumor with IGRT guided by OSMS at the Ramathibodi Radiosurgery Center during January 2016 to December 2017.
Results: A median prescribed dose of 50 Gy (range: 36-60) in 25 fractions (range: 22-30) was used. The median planning target volume was 20.65 cm3 (range: 0.4-485). The mean set-up error measured on pretreatment cone beam computerized tomography (CBCT) and OSMS was very small (<1 mm, 1 degree) in all directions. The maximum mean difference of deviation between CBCT and OSMS was 0.29±0.17 mm in lateral direction, and 0.08±0.14° in pitch direction. Less than 5% of patients needed to be repositioned during treatment. The treatment was well-tolerated by all patients, and no severe treatment-associated toxicity was reported.
Conclusion: IGRT guided by OSMS was found to be an efficacious, radiation-limiting treatment method for the management of intracranial tumors.
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