การศึกษาการทำนายระยะเวลารอดชีวิตของผู้ป่วยมะเร็งระยะสุดท้ายโดยใช้ Palliative Prognostic Index (PPI) ที่ศูนย์มะเร็งอุบลราชธานี

Abstract

Purpose To evaluate the predictive accuracy of the Palliative Prognostic index (PPI) in patients with advanced cancer at Ubonratchatani cancer center. Patients and Methods The PPI (defi ned by performance status, oral intake, edema, dyspnea and delirium) was calculated in 34 consecutive patients with advanced cancer hospitalized at palliative care unit. Patients were classifi ed into three groups: group A (PPI<2.0), group B (2.0<PPI<4.0), and group C (PPI>4.0). The survival curves and the 95% confi dence intervals of survival were calculated by the Kaplan-Meier method, and the comparisons among three groups were based on the log-rank test. Cut-off points for survival prediction of shorter than 3 or 6 weeks were determined and the validity of the prediction was examined. Results Group B survived signifi cantly longer than group C, and group A survived signifi cantly longer than either of the others. When a PPI of more than 6 was adopted as a cut-off point, 3 weeks’ survival was predicted with a sensitivity of 79% and a specifi city of 85%. When a PPI of more than 4 was used as a cut-off point, 6 weeks’ survival was predicted with a sensitivity of 72% and a specifi city of 75%. Conclusion The survival of advanced cancer patients can be acceptably predicted by PPI.