Osteopenia/Osteoporosis from pelvic irradiation in premenopausal cervical cancer at Mahavajiralongkorn Thanyaburi Hospital
Keywords:
cervical cancer, osteopenia, osteoporosis, premenopausal, radiotherapyAbstract
Backgrounds: In premenopausal women who received radiotherapy at pelvic region for cervical cancer that induced early post menopause. This led to develop osteopenia and/or osteoporosis as the same as postmenopausal women. This retrospective study is conducted to demonstrated incidence of osteopenia and/or osteoporosis after pelvic irradiation in premenopausal cervical cancer. Material and method: Retrospective, descriptive study of premenopausal cervical cancer who received radiotherapy at pelvic region at Mahavajiralongkorn Thanyaburi Hospital since 1 October 2007 to 30 September 2012. Results: The total premenopausal cervical cancer were163 patients, median age were 43.23 + 4.68 (28.4 - 52.1) years old and median BMI was 24.65 + 4.49 (15.79 – 41.65) kg/m2. They received radiotherapy with four fields box technique (57.67%), intracavitary high dose rate brachytherapy (98.77%) and without chemotherapy treatment (61.97%). There was no history of previous bone fracture (95.09%) and the most of patients had no previous hysterectomy (90.18%) and no previous oophorectomy (98.77%). After follow-up, the incidence of osteopenia and osteoporosis were 22.70% and 6.13%, respectively. The factor which affected of osteopenia and osteoporosis in this study were history of coffee or tea drinking (p = 0.028), exercise (p = 0.010) and history of bone fracture (p = 0.034). Conclusion: At Mahavajiralongkorn Thanyaburi Hospital, radiotherapy at pelvic region in premenopausal cervical cancer induced osteopenia/osteoporosis higher than normal Thai female population. The factors which affected in this study included history of coffee or tea drinking, exercise and history of bone fracture.
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บทความที่ได้รับการตีพิมพ์เป็นลิขสิทธิ์ของวารสารมะเร็งวิวัฒน์ ข้อความที่ปรากฏในบทความแต่ละเรื่องในวารสารวิชาการเล่มนี้เป็นความคิดเห็นส่วนตัวของผู้เขียนแต่ละท่านไม่เกี่ยวข้องกับ และบุคคลากรท่านอื่น ๆ ใน สมาคมฯ แต่อย่างใด ความรับผิดชอบองค์ประกอบทั้งหมดของบทความแต่ละเรื่องเป็นของผู้เขียนแต่ละท่าน หากมีความผิดพลาดใดๆ ผู้เขียนแต่ละท่านจะรับผิดชอบบทความของตนเองแต่ผู้เดียว
