The effects of developing medication reconciliation on medication errors at Pakkred Hospital
Keywords:
medication reconciliation, medication errors, transitions of care, chronic diseasesAbstract
Background: Medication errors are a common issue among patients with chronic diseases such as hypertension, diabetes, and cardiovascular conditions, particularly during transitions of care such as admission, interdepartmental transfer, or discharge from the hospital. To enhance medication safety, Pakkred Hospital has developed and implemented a medication reconciliation (MR) process. MR is a systematic approach to reviewing and verifying the accuracy of a patient's medication information.
Objective: This study aims to evaluate the effectiveness of the MR process on reducing Medication Errors within Pakkred Hospital.
Methods: This study was a quasi-experimental study conducted at Pakkred Hospital during February – June 2025. The study population consisted of 310 inpatients diagnosed with at least one chronic condition, including hypertension, diabetes mellitus, or cardiovascular disease, regardless of age and gender. Participants were divided into two groups: pre- and post-implementation of MR process. Descriptive statistics were used. Inferential statistics included Fisher’s Exact Test Chi-square test and incidence rate analysis.
Results: Most patients were male (53.55%), with a mean age of 68.84 ± 12.75 years, 60.97% were aged between 61 and 80 years. The most common comorbidities were hypertension (46.45%) and combined hypertension with diabetes (34.84%). The median length of hospital stay was 5 days (IQR = 4), and the median number of medications received per patient was 7 (IQR = 3). After implementing the MR process, the medication error rate significantly decreased from 11.73 to 4.62 events per 1,000 prescriptions (p = 0.046). The number of patients experiencing medication errors also declined significantly, from 27 patients (17.42%) to 5 patients (3.23%) (p = 0.001).
Conclusion: The implementation of the medication reconciliation (MR) process significantly reduced medication errors and enhanced medication safety for patients. These findings highlight the effectiveness of MR as a critical intervention in improving the quality of care, particularly during transitions of care in hospitalized patients with chronic diseases.
References
World Health Organization. Medication errors: technical series on safer primary care [Internet]. Geneva: World Health Organization; c2016 [updated 2016 Dec 13; cited 2025 May 3]. Available from: https://www.who.int/publications/i/item/9789241511643
Hfocus. Accelerating patient and healthcare personnel safety towards becoming a 2P Safety Hospital [Internet]. c2018 [updated 2018 Nov 11; cited 2024 Oct 1]. Available from: https://www.hfocus.org/content/2018/11/16536 [In Thai]
Ningsanon T, Chulawattanat S, Mantakanthikun P, Hospital Pharmacy Association of Thailand (HPAT). Prevention of medication errors for patient safety. 2nd ed. Bangkok: Hospital Pharmacy Association of Thailand (HPAT); 2005. p. 2-25. [In Thai]
Redmond P, Grimes TC, McDonnell R, Boland F, Hughes C, Fahey T. Impact of medication reconciliation for improving transitions of care. Cochrane Database Syst Rev. 2018;8(8):CD010791. doi: 10.1002/14651858.CD010791.pub2.
Schnipper JL, Kirwin JL, Cotugno MC, Wahlstrom SA, Brown BA, Tarvin E, et al. Role of pharmacist counseling in preventing adverse drug events after hospitalization. Arch Intern Med. 2006;166(5):565-71. doi: 10.1001/archinte.166.5.565.
Praphanwattana M. Safety Medication System. Bangkok: Paramat Printing Co., Ltd.; 2010. p. 288–97. [In Thai]
Dean B, Schachter M, Vincent C, Barber N. Prescribing errors in hospital inpatients: their incidence and clinical significance. Qual Saf Health Care. 2002;11(4):340-4. doi: 10.1136/qhc.11.4.340.
Mueller SK, Sponsler KC, Kripalani S, Schnipper JL. Hospital-based medication reconciliation practices: a systematic review. Arch Intern Med. 2012;172(14):1057-69. doi: 10.1001/archinternmed.2012.2246.
Boockvar KS, Santos SL, Kushniruk A, Johnson C, Nebeker JR. Medication reconciliation: barriers and facilitators from the perspectives of resident physicians and pharmacists. J Hosp Med. 2011;6(6):329-37. doi: 10.1002/jhm.891.
Ningsanon T, Mantakanthikun P, Chulawattanat S. Medication Reconciliation. Bangkok: Hospital Pharmacy Association of Thailand (HPAT); 2008. p.2-5. [In Thai]
Ningsanond T, Rattanavijitsarsilp S. Hospital drug system performance indicators. Bangkok: Paramat Printing Co., Ltd.; 2008. p. 40–6. [In Thai]
Institute for Healthcare Improvement (IHI). How-to guide: prevent adverse drug events by implementing medication reconciliation. Cambridge (MA): IHI; 2011. p. 40. Available from: https://www.scribd.com/document/578241052/HowtoGuidePreventADEs
Barnsteiner JH. Medication Reconciliation. In: Hughes RG, editor. Patient Safety and Quality: An Evidence-Based Handbook for Nurses. Rockville (MD): Agency for Healthcare Research and Quality (US); 2008 Apr. Chapter 38. Available from: https://www.ncbi.nlm.nih.gov/books/NBK2648/
UCLA. Two independent proportions power analysis | G*Power Data Analysis Examples [Internet]. Los Angeles (CA): UCLA; c2022 [cited 2025 Jun 7]. Available from: https://stats.oarc.ucla.edu/other/gpower/two-independent-proportions-power-analysis/
Lemeshow S, Hosmer DW, Klar J, Lwanga SK. Adequacy of sample size in health studies. Chichester: John Wiley & Sons Ltd.; 1990. p. 39–42.
Mekonnen AB, McLachlan AJ, Brien JA. Effectiveness of pharmacist-led medication reconciliation programmes on clinical outcomes at hospital transitions: a systematic review and meta-analysis. BMJ Open. 2016;6(2):e010003. doi: 10.1136/bmjopen-2015-010003.
Hashemi R, Rabizadeh S, Yadegar A, Mohammadi F, Rajab A, Karimpour Reyhan S, et al. High prevalence of comorbidities in older adult patients with type 2 diabetes: a cross-sectional survey. BMC Geriatr. 2024;24(1):873. doi: 10.1186/s12877-024-05483-3.
Institute for Safe Medication Practices Canada (ISMP Canada). Medication Reconciliation (MedRec) [Internet]. Toronto: ISMP Canada; c2023 [cited 2025 Jun 7]. Available from: https://www.ismp-canada.org/medrec/
Boockvar KS, Blum S, Kugler A, Livote E, Mergenhagen KA, Nebeker JR, et al. Effect of admission medication reconciliation on adverse drug events from admission medication changes. Arch Intern Med. 2011;171(9):860-1. doi: 10.1001/archinternmed.2011.163.
George D, Supramaniam ND, Hamid SQA, Hassali MA, Lim WY, Hss AS. Effectiveness of a pharmacist-led quality improvement program to reduce medication errors during hospital discharge. Pharm Pract (Granada). 2019;17(3):1501. doi: 10.18549/PharmPract.2019.3.1501.
Khansa SA, Mukhtar A, Abduljawad M, Aseeri M. Impact of medication reconciliation upon discharge on reducing medication errors. J Pharmacovigil. 2016;4(6):1-5. doi: 10.4172/2329-6887.1000222.
Caleres G, Modig S, Midlöv P, Chalmers J, Bondesson Å. Medication Discrepancies in Discharge Summaries and Associated Risk Factors for Elderly Patients with Many Drugs. Drugs Real World Outcomes. 2020;7(1):53-62. doi: 10.1007/s40801-019-00176-5.
Schnipper JL, Hamann C, Ndumele CD, Liang CL, Carty MG, Karson AS, et al. Effect of an electronic medication reconciliation application and process redesign on potential adverse drug events: a cluster-randomized trial. Arch Intern Med. 2009;169(8):771-80. doi: 10.1001/archinternmed.2009.51.
Kwan JL, Lo L, Sampson M, Shojania KG. Medication reconciliation during transitions of care as a patient safety strategy: a systematic review. Ann Intern Med. 2013;158(5 Pt 2):397-403. doi: 10.7326/0003-4819-158-5-201303051-00006.
Boockvar KS, Carlson LaCorte H, Giambanco V, Fridman B, Siu A. Medication reconciliation for reducing drug-discrepancy adverse events. Am J Geriatr Pharmacother. 2006;4(3):236-43. doi: 10.1016/j.amjopharm.2006.09.003.
Lehnbom EC, Stewart MJ, Manias E, Westbrook JI. Impact of medication reconciliation and review on clinical outcomes. Ann Pharmacother. 2014;48(10):1298-312. doi: 10.1177/1060028014543485.
Gleason KM, Groszek JM, Sullivan C, Rooney D, Barnard C, Noskin GA. Reconciliation of discrepancies in medication histories and admission orders of newly hospitalized patients. Am J Health Syst Pharm. 2004;61(16):1689-95. doi: 10.1093/ajhp/61.16.1689.
World Health Organization (WHO). The high 5s project: interim report [Internet]. Switzerland: WHO; c2014 [updated 2013 Dec 14; cited 2025 Jun 8] Available from: https://www.who.int/initiatives/high-5s-standard-operating-procedures
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