Incidence and factors related to seroma formation after Modified Radical Mastectomy in breast cancer patients in Nakornping Hospital
Keywords:
breast cancer, seroma , risk factors , mastectomy with axillary lymph node dissectionAbstract
Introduction: Seroma Formation is the most frequent post operative complication after Breast Cancer Surgery. The etiology of which problem remained obscure. The aim of this study was to analyse the impact of selected factors on the incidence of seroma formation in breast cancer patients who received surgery by Modified Radical Mastectomy in Nakornping Hospital.
Materials and Methods: A retrospective analysis of 100 breast cancer patients who received surgery by Modified Radical Mastectomy from 1 January 2019 to 31 December 2019 at Nakornping Hospital .The data related with the formation of seroma after surgery were collected correlated with selected parameters of patients which are patient demographics (Age , BMI , Underlying disease), clinical and pathologic of breast cancer (Stage of cancer, Neoadjuvant chemotherapy, Number of lymph node), operative time, duration of retaining surgical drains and volume of drainage output. Univariable and multivariable binary regression methods were used to Identify correlated factors
Results: There were 100 breast cancer patients enrolled in this study.The incidence of seroma was 28 cases ( 28% ) .The seroma group and non seroma group had an average age of 55.6+/-11.5 and 56.3+/-11.3 years . Disease stage were stage 1,2,3,4 : 25.0%,39.3%,25.6%,7.1% and 12.5%,56.9%,29.2%,1.4% respectively.Received Neoadjuvant chemotherapy before surgery 17.9% and 11.2% respectively. The baseline data of both group of patients were not statistically different. Patients with total drainage volume equal or greater than 900 cc were associated with seroma formation RR 1.94 (95% CI 1.06-3.57 , p=0.033) .When controlling for related factors , it was found that total drainage volume equal or greater than 900 cc was associated with seroma formation Adj. RR 2.25 ( 95% CI 1.16-4.35 , p=0.016)
Conclusion: In our study, risk of seroma formation after Modified Radical Mastectomy was significantly correlated with total drainage volume from both drains that placed under surgical wound and axillary area (surgical site). However, further study on seroma formation should be performed to clearly identify risk factors and reduce this complication.
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