Early predictive factors for death in pediatric myocarditis: 5 years retrospective study
Keywords:
myocarditis, pediatric, prognostic, diagnosis, mortality rateAbstract
Objective: The purpose of this study was to investigate the association between the risk factors and the mortality rate of myocarditis in pediatric population.
Method: A retrospective cohort study chart review was performed at Nakornping hospital. Medical records were searched between 1st July 2016 and 1st June 2021 for patients at birth to 15 years of age admitting with myocarditis. The study population comprised 52 patients and compared the risk ratio between the survival group and death group.
Result: Total 52 children, 28 boys and 24 girls were included into the study of those, total deaths were 15 cases, 28.8%. Median age of death and survived cases were 6.2 [2-38.9] and 18 [4.4-89] months respectively. Confirmed myocarditis cases had various signs and symptoms that related to their mortality. The study found that in patients with chest wall retraction had Adjusted odds ratio of 1.30 (p<0.001), LVEF < 55% had Adjusted odds ratio of 2.87 (p = 0.045) and blood lactate had Adjusted odds ratio of 13.60 (p < 0.001). The data was investigated by using ROC analysis and showed three risk factors were able to predict the mortality in children with myocarditis 94.62%.
conclusion: The model demonstrated that the risk factor; chest wall retraction, LVEF<55% at first admission and blood lactate > 8 mmol/L associated the mortality rate of myocarditis in pediatric population which is 28.85% in Nakornping hospital.
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