Prevalence of growth impairment and time to catch-up growth in HIV-infected children after receiving antiretroviral therapy
Keywords:
HIV-infected children, Growth impairment, stunting, underweight, catch-up growthAbstract
Objective : To study prevalence of growth impairment, time to catch-up growth and factors associated with catch-up growth in HIV-infected children after receiving antiretroviral therapy.
Method : A retrospective cohort study among HIV-infected children, aged < 18 years old after receiveing antiretroviral therapy (ART), had follow up time more than 1 year in Nakornping hospital. Data collection had started from 2002 to 2018. Baseline data included age, sex, body weight, height, immune status, disease severity, ART, anemia, opportunistic infections and follow up time were used to analyze the growth impairment.
Result : Total 126 cases were eligible for the analysis, female 71 cases(56.30%), median age at starting ART 7.8 years old (iqr 5.75). At base line, 68 cases (54.0%) children had growth impairment. Moderate and severe immune suppression was increased risk of growth impairment, Adj.OR 2.14 (95% CI 1.14-4.02). Catch-up growth rate was 70.59%, median time to catch-up growth was 3.46 years (iqr 5.08). Incidence rate of catch-up growth was 6.81 per 1000 months-person. Severe stunting had higher risk of not able to catch-up growth than moderate stunting, Crude HR 0.46, 95% CI 0.25-0.83.
Conclusion : High growth impairment rate was seen in our cohort however their growth was likely to be attained. Severe stunting was a factor that associated with less achievement in normal growth.
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